PathWhiz

PathWhiz ID	Pathway	Meta Data
PW122597 View Pathway	metabolic Asparagine Biosynthesis Pseudomonas aeruginosa Asparagine is an amino acid used in protein synthesis, specifically the biosynthesis of glycoproteins. In E.coli, L-asparagine can be synthesized from L-aspartic acid by either utilizing asparagine synthetase B with L-glutamine or ammonia. Both reactions are driven by ATP however the reaction with ammonia utilizes both asparagine synthetase B and aspartate-ammonia ligase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 18:20 Last Updated: August 12, 2019 at 18:20
PW000813 View Pathway	metabolic Asparagine Biosynthesis Escherichia coli Asparagine is an amino acid used in protein synthesis, specifically the biosynthesis of glycoproteins. In E.coli, L-asparagine can be synthesized from L-aspartic acid by either utilizing asparagine synthetase B with L-glutamine or ammonia. Both reactions are driven by ATP however the reaction with ammonia utilizes both asparagine synthetase B and aspartate-ammonia ligase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: March 16, 2015 at 16:53 Last Updated: March 16, 2015 at 16:53
PW002274 View Pathway	metabolic Asparagine Metabolism Saccharomyces cerevisiae In both eukaryotes and prokaryotes, L-asparagine is biosynthesized from L-aspartate by amidation using L-glutamine as an amino group donor which both of reactions are driven by ATP. In the first reaction, asparagine synthetase [glutamine-hydrolyzing] 1 catalyzes L-aspartic acid to form L-Asparagine. In the second reactions, asparagine synthetase [glutamine-hydrolyzing] 1 and 2 both catalyze L-aspartic acid to form L-Asparagine. Asparagine gets metabolized back into L-aspartic acid by reacting with water through a L-asparaginase 1 resulting in the release of ammonium and L-aspartic acid. The only known role of L-asparagine is incorporation into proteins. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: November 02, 2015 at 10:39 Last Updated: November 02, 2015 at 10:39
PW002527 View Pathway	metabolic Asparagine Metabolism Arabidopsis thaliana Asparagine is one of the twenty amino acids that combine to construct proteins according to the genetic code. In both eukaryotes and prokaryotes, L-asparagine is biosynthesized from L-aspartate via amidation using L-glutamine as an amino group donor. The first of the two reactions involved is catalyzed by asparagine synthetase [glutamine-hydrolyzing] 1. However, the second reaction is catalyzed by both asparagine synthetase [glutamine-hydrolyzing] 1 and 2. Asparagine synthetase 1 is negatively controlled by light and sucrose whereas asparagine synthetase 2 is positively controlled by light and sucrose. Asparagine gets metabolized back into L-aspartic acid by reacting with water through an L-asparaginase, resulting in the release of ammonium and L-aspartic acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: April 15, 2016 at 16:35 Last Updated: April 15, 2016 at 16:35
PW088388 View Pathway	metabolic Aspartate Metabolism Drosophila melanogaster Aspartate is synthesized by transamination of oxaloacetate by aspartate aminotransferase or amino acid oxidase. Aspartyl-tRNA synthetase can then couple aspartate to aspartyl tRNA for protein synthesis. The aspartate content in human proteins is about 7%. Asparagine synthase can convert aspartate to the polar amino acid asparagine. Aspartate is also a precursor for cellular signaling compounds such as, N-acetyl-aspartate, beta-alanine, adenylsuccinate, arginino-succinate and N-carbamoylaspartate. Aspartate is also a metabolite in the urea cycle and involved in gluconeogenesis. Additionally, aspartate carries the reducing equivalents in the mitochondrial malate-aspartate shuttle, which utilizes the ready interconversion of aspartate and oxaloacetate. The conjugate base of L-aspartic acid, aspartate, also acts as an excitatory neurotransmitter in the brain which activates NMDA receptors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 15:30 Last Updated: August 10, 2018 at 15:30
PW000787 View Pathway	metabolic Aspartate Metabolism Escherichia coli Aspartate is synthesized from and broken down to oxaloacetate, a TCA cycle intermediate, via a reversible transamination reaction with glutamate. This reaction is catalyzed by the aminotransferase AspC or TyrB. Aspartate is a component of proteins and is involved in many biosyntheses pathways like NAD biosynthesis and beta-alanine metabolism. Aspartate can also be synthesized from fumaric acid through an aspartate ammonia lyase. Aspartate also participates in the synthesis of L-asparagine through two different methods, either through aspartate ammonia ligase or asparagine synthetase B. Aspartate is also a precursor of fumaric acid. Again it has two possible ways of synthesizing it. First set of reactions follows an adenylo succinate synthetase that yields adenylsuccinic acid and then adenylosuccinate lyase in turns leads to fumaric acid. The second way is through argininosuccinate synthase that yields argininosuccinic acid and then argininosuccinate lyase in turns leads to fumaric acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: March 01, 2015 at 20:00 Last Updated: March 01, 2015 at 20:00
PW088295 View Pathway	metabolic Aspartate Metabolism Rattus norvegicus Aspartate is synthesized by transamination of oxaloacetate by aspartate aminotransferase or amino acid oxidase. Aspartyl-tRNA synthetase can then couple aspartate to aspartyl tRNA for protein synthesis. The aspartate content in human proteins is about 7%. Asparagine synthase can convert aspartate to the polar amino acid asparagine. Aspartate is also a precursor for cellular signaling compounds such as, N-acetyl-aspartate, beta-alanine, adenylsuccinate, arginino-succinate and N-carbamoylaspartate. Aspartate is also a metabolite in the urea cycle and involved in gluconeogenesis. Additionally, aspartate carries the reducing equivalents in the mitochondrial malate-aspartate shuttle, which utilizes the ready interconversion of aspartate and oxaloacetate. The conjugate base of L-aspartic acid, aspartate, also acts as an excitatory neurotransmitter in the brain which activates NMDA receptors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 13:17 Last Updated: August 10, 2018 at 13:17
PW122579 View Pathway	metabolic Aspartate Metabolism Pseudomonas aeruginosa Aspartate is synthesized from and broken down to oxaloacetate, a TCA cycle intermediate, via a reversible transamination reaction with glutamate. This reaction is catalyzed by the aminotransferase AspC or TyrB. Aspartate is a component of proteins and is involved in many biosyntheses pathways like NAD biosynthesis and beta-alanine metabolism. Aspartate can also be synthesized from fumaric acid through an aspartate ammonia lyase. Aspartate also participates in the synthesis of L-asparagine through two different methods, either through aspartate ammonia ligase or asparagine synthetase B. Aspartate is also a precursor of fumaric acid. Again it has two possible ways of synthesizing it. First set of reactions follows an adenylo succinate synthetase that yields adenylsuccinic acid and then adenylosuccinate lyase in turns leads to fumaric acid. The second way is through argininosuccinate synthase that yields argininosuccinic acid and then argininosuccinate lyase in turns leads to fumaric acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 17:01 Last Updated: August 12, 2019 at 17:01
PW088184 View Pathway	metabolic Aspartate Metabolism Bos taurus Aspartate is synthesized by transamination of oxaloacetate by aspartate aminotransferase or amino acid oxidase. Aspartyl-tRNA synthetase can then couple aspartate to aspartyl tRNA for protein synthesis. The aspartate content in human proteins is about 7%. Asparagine synthase can convert aspartate to the polar amino acid asparagine. Aspartate is also a precursor for cellular signaling compounds such as, N-acetyl-aspartate, beta-alanine, adenylsuccinate, arginino-succinate and N-carbamoylaspartate. Aspartate is also a metabolite in the urea cycle and involved in gluconeogenesis. Additionally, aspartate carries the reducing equivalents in the mitochondrial malate-aspartate shuttle, which utilizes the ready interconversion of aspartate and oxaloacetate. The conjugate base of L-aspartic acid, aspartate, also acts as an excitatory neurotransmitter in the brain which activates NMDA receptors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 10:39 Last Updated: August 10, 2018 at 10:39
PW000002 View Pathway	metabolic Aspartate Metabolism Homo sapiens Aspartate is synthesized by transamination of oxaloacetate by aspartate aminotransferase or amino acid oxidase. Aspartyl-tRNA synthetase can then couple aspartate to aspartyl tRNA for protein synthesis. The aspartate content in human proteins is about 7%. Asparagine synthase can convert aspartate to the polar amino acid asparagine. Aspartate is also a precursor for cellular signaling compounds such as, N-acetyl-aspartate, beta-alanine, adenylsuccinate, arginino-succinate and N-carbamoylaspartate. Aspartate is also a metabolite in the urea cycle and involved in gluconeogenesis. Additionally, aspartate carries the reducing equivalents in the mitochondrial malate-aspartate shuttle, which utilizes the ready interconversion of aspartate and oxaloacetate. The conjugate base of L-aspartic acid, aspartate, also acts as an excitatory neurotransmitter in the brain which activates NMDA receptors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 01, 2013 at 13:54 Last Updated: August 01, 2013 at 13:54