PathWhiz

PathWhiz ID	Pathway	Meta Data
PW002529 View Pathway	metabolic Aspartate Metabolism Arabidopsis thaliana Aspartate is synthesized from oxaloacetic acid and l-glutamate in the cytosol, the chloroplast, the mitochondria and the peroxisome. Aspartate is broken down via conversion to malate, a part of the reversible malate-aspartate shuttle in the mitochondrial and cytoplasmic space. This shuttle involves the transfer of reduction equivalents across the mitochondrial membrane to produce ATP. NADH is unable to cross the inner mitochondrial membrane. Therefore, the shuttle allows electrons from NADH in the cytosol, a product of glycolysis, to cross the inner mitochondrial membrane to produce ATP. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: April 18, 2016 at 15:38 Last Updated: April 18, 2016 at 15:38
PW064572 View Pathway	metabolic Aspartate Metabolism Mus musculus Aspartate is synthesized by transamination of oxaloacetate by aspartate aminotransferase or amino acid oxidase. Aspartyl-tRNA synthetase can then couple aspartate to aspartyl tRNA for protein synthesis. The aspartate content in human proteins is about 7%. Asparagine synthase can convert aspartate to the polar amino acid asparagine. Aspartate is also a precursor for cellular signaling compounds such as, N-acetyl-aspartate, beta-alanine, adenylsuccinate, arginino-succinate and N-carbamoylaspartate. Aspartate is also a metabolite in the urea cycle and involved in gluconeogenesis. Additionally, aspartate carries the reducing equivalents in the mitochondrial malate-aspartate shuttle, which utilizes the ready interconversion of aspartate and oxaloacetate. The conjugate base of L-aspartic acid, aspartate, also acts as an excitatory neurotransmitter in the brain which activates NMDA receptors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: January 21, 2018 at 20:05 Last Updated: January 21, 2018 at 20:05
PW088445 View Pathway	metabolic Aspartate Metabolism Caenorhabditis elegans Aspartate is synthesized by transamination of oxaloacetate by aspartate aminotransferase or amino acid oxidase. Aspartyl-tRNA synthetase can then couple aspartate to aspartyl tRNA for protein synthesis. The aspartate content in human proteins is about 7%. Asparagine synthase can convert aspartate to the polar amino acid asparagine. Aspartate is also a precursor for cellular signaling compounds such as, N-acetyl-aspartate, beta-alanine, adenylsuccinate, arginino-succinate and N-carbamoylaspartate. Aspartate is also a metabolite in the urea cycle and involved in gluconeogenesis. Additionally, aspartate carries the reducing equivalents in the mitochondrial malate-aspartate shuttle, which utilizes the ready interconversion of aspartate and oxaloacetate. The conjugate base of L-aspartic acid, aspartate, also acts as an excitatory neurotransmitter in the brain which activates NMDA receptors. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 16:49 Last Updated: August 10, 2018 at 16:49
PW002375 View Pathway	metabolic Aspartate Metabolism Saccharomyces cerevisiae Aspartate (also named as L-aspartic acid) is an α-amino acid that can be used for protein biosynthesis. Oxalacetic acid is produced from aspartic acid by mitochondrial aspartate aminotransferase, then oxalacetic acid is reduced to malic acid by malate dehydrogenase. Malic acid enters mitochondria through mitochondrial dicarboxylate transporter and forms oxalacetic acid by facilitation of malate dehydrogenase. In the final step, oxalacetic acid is catalyzed by mitochondrial aspartate aminotransferase to form aspartate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: December 02, 2015 at 17:01 Last Updated: December 02, 2015 at 17:01
PW064431 View Pathway	metabolic Aspartate Metabolism 1512214152 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: December 02, 2017 at 04:30 Last Updated: December 02, 2017 at 04:30
PW126786 View Pathway	metabolic Aspartate Metabolism 1648490207 Pseudomonas aeruginosa Aspartate is synthesized from and broken down to oxaloacetate, a TCA cycle intermediate, via a reversible transamination reaction with glutamate. This reaction is catalyzed by the aminotransferase AspC or TyrB. Aspartate is a component of proteins and is involved in many biosyntheses pathways like NAD biosynthesis and beta-alanine metabolism. Aspartate can also be synthesized from fumaric acid through an aspartate ammonia lyase. Aspartate also participates in the synthesis of L-asparagine through two different methods, either through aspartate ammonia ligase or asparagine synthetase B. Aspartate is also a precursor of fumaric acid. Again it has two possible ways of synthesizing it. First set of reactions follows an adenylo succinate synthetase that yields adenylsuccinic acid and then adenylosuccinate lyase in turns leads to fumaric acid. The second way is through argininosuccinate synthase that yields argininosuccinic acid and then argininosuccinate lyase in turns leads to fumaric acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: March 28, 2022 at 11:56 Last Updated: March 28, 2022 at 11:56
PW126787 View Pathway	metabolic Aspartate Metabolism 1648490310 Pseudomonas aeruginosa Aspartate is synthesized from and broken down to oxaloacetate, a TCA cycle intermediate, via a reversible transamination reaction with glutamate. This reaction is catalyzed by the aminotransferase AspC or TyrB. Aspartate is a component of proteins and is involved in many biosyntheses pathways like NAD biosynthesis and beta-alanine metabolism. Aspartate can also be synthesized from fumaric acid through an aspartate ammonia lyase. Aspartate also participates in the synthesis of L-asparagine through two different methods, either through aspartate ammonia ligase or asparagine synthetase B. Aspartate is also a precursor of fumaric acid. Again it has two possible ways of synthesizing it. First set of reactions follows an adenylo succinate synthetase that yields adenylsuccinic acid and then adenylosuccinate lyase in turns leads to fumaric acid. The second way is through argininosuccinate synthase that yields argininosuccinic acid and then argininosuccinate lyase in turns leads to fumaric acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: March 28, 2022 at 11:58 Last Updated: March 28, 2022 at 11:58
PW144271 View Pathway	drug action Aspartic acid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:04 Last Updated: October 07, 2023 at 13:04
PW000458 View Pathway	disease Aspartylglucosaminuria Homo sapiens Aspartylglucosaminuria is an autosomal recessive disorder of lysosomal storage caused by a mutation in the AGA gene which codes for N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase. A deficiency in this enzyme results in accumulation of aspartylglycosamine and oligosaccharides in urine. Symptoms, which present in childhood, include skeletal changes, speech abnormalities, macroglossia, and mental retardation. Treatment includes bone marrow transplants. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 24, 2013 at 23:38 Last Updated: August 24, 2013 at 23:38
PW147009 View Pathway	metabolic Aspirin Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:38 Last Updated: October 10, 2023 at 13:38