PathWhiz

PathWhiz ID	Pathway	Meta Data
PW127586 View Pathway	drug action Azilsartan medoxomil Action Pathway Homo sapiens Azilsartan medoxomil is a prodrug, it is metabolised in azilsartan during the absorption of the drug in the gastrointestinal tract. Azilsartan is in the angiotensin-receptor blocking (ARB) drug class. This drug selectively binds to AT1 receptors as an antagonist, blocking vasoconstrictor and the aldosterone secretion that angiotensin II provokes (RAAS). Angiotensin II usually binds to angiotensin II type 1 receptor (AT1 receptor) to stimulate the synthesis of aldosterone and promote renal tubular reabsorption of sodium. This molecule also inhibits secretion of renin. The antagonist (azilsartan) of those AT1 receptor provokes a decrease in blood pressure. This drug is available as a tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: May 11, 2023 at 10:51 Last Updated: May 11, 2023 at 10:51
PW145845 View Pathway	drug action Azilsartan medoxomil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:48 Last Updated: October 07, 2023 at 16:48
PW175977 View Pathway	metabolic Azilsartan medoxomil Predicted Metabolism Pathway new Homo sapiens Metabolites of Azilsartan medoxomil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 12:56 Last Updated: November 29, 2023 at 12:56
PW000345 View Pathway	drug action Azithromycin Action Pathway Homo sapiens Azithromycin, trade names include Zithromax and Azithrocin, is a semisynthetic azalide derived from erythromycin. Azalides are part of the macrolide antibiotic class. Azithromycin targets protein synthesis of bacteria by binding to the 50S subunit of the bacterial ribosome to inhibit mRNA translation and prevent bacteria growth. Macrolides are broad spectrum antibiotics. It is prescribed to treat bacterial infections including: sexually transmitted infections like chlamydia, pneumonia, strep throat, ear infections, sinusitis and more. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW128343 View Pathway	drug action Azithromycin Action Pathway Homo sapiens Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It is commonly administered via oral consumption and diffuses throughout the body. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually transmitted and enteric infections. Like other macrolide antimicrobials, azithromycin binds to the 23S portion of the 50S bacterial ribosomal subunit. It inhibits bacterial protein synthesis by preventing the addition of aminoacyl-tRNA to the growing protein through the ribosome. Inhibition of protein synthesis leads to apoptosis of the bacteria since essential proteins required for the bacteria to survive are not being produced. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 22, 2023 at 15:21 Last Updated: August 22, 2023 at 15:21
PW126592 View Pathway	drug action Azithromycin Action Pathway (New) Homo sapiens Azithromycin is a macrolide antibiotic used to treat a variety of bacterial infections. It is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually transmitted and enteric infections. Like other macrolide antimicrobials, azithromycin binds to the 23S portion of the 50S bacterial ribosomal subunit. It inhibits bacterial protein synthesis by preventing the transit of aminoacyl-tRNA and the growing protein through the ribosome. Inhibition of protein synthesis kills the bacteria since essential proteins required for the bacteria to survive are not being produced. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: January 19, 2022 at 00:40 Last Updated: January 19, 2022 at 00:40
PW144338 View Pathway	drug action Azithromycin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:26 Last Updated: October 07, 2023 at 13:26
PW176321 View Pathway	metabolic Azithromycin Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:03 Last Updated: December 07, 2023 at 15:03
PW127498 View Pathway	drug action Azlocillin Action Pathway Clostridium perfringens (strain 13 / Type A) Azlocillin is a semisynthetic ampicillin-derived acylureido penicillin used for the treatment of bacterial infections caused by Pseudomonas aeruginosa, Escherichia coli, and Haemophilus influenzae. It inhibits specific penicillin-binding proteins located in the perisome of bacteria cells, which is the third and last stage of bacterial cell wall syntheis. This causes cell lysis and therefore the breakdown of the bacterial cell. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: March 21, 2023 at 02:37 Last Updated: March 21, 2023 at 02:37
PW145153 View Pathway	drug action Azlocillin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:11 Last Updated: October 07, 2023 at 15:11