PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146635 View Pathway	drug action Benziodarone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:41 Last Updated: October 07, 2023 at 18:41
PW132332 View Pathway	metabolic Benznidazole Drug Metabolism Homo sapiens Benznidazole is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Benznidazole passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:56 Last Updated: September 21, 2023 at 20:56
PW146481 View Pathway	drug action Benznidazole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:18 Last Updated: October 07, 2023 at 18:18
PW248089 View Pathway	metabolic Benzoate degradation I Aromatoleum aromaticum Benzoate, an environmental pollutant, is utilized by bacteria such as Aromatoleum aromaticum to yield energy and carbon. While the precise transport mechanisms remain under research, it is proposed that benzoate is transported across the cell membrane passively or actively via transport proteins such as permeases and porins. Benzoate is then converted to benzoyl-CoA by benzoate-CoA ligase. Benzoyl-CoA then undergoes further degradation, catalyzed by enzymes like benzoyl-CoA reductase, leading to the formation of intermediate cyclohexane compounds which are ultimately converted into central metabolites that can enter the citrate cycle for further energy generation BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: May 16, 2024 at 15:10 Last Updated: May 16, 2024 at 15:10
PW248105 View Pathway	metabolic Benzoate degradation II Aromatoleum aromaticum Benzoate, an environmental pollutant, is utilized by bacteria such as Aromatoleum aromaticum to yield energy and carbon. While the precise transport mechanisms remain under research, it is proposed that benzoate is transported across the cell membrane passively or actively via transport proteins such as permeases and porins. Benzoate is then converted to benzoyl-CoA by benzoate-CoA ligase. Benzoyl-CoA is then used for phenylalanine metabolism and processes e.g., biosynthesis of alkaloids BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: May 16, 2024 at 20:39 Last Updated: May 16, 2024 at 20:39
PW126630 View Pathway	drug action Benzocaine Homo sapiens Benzocaine is a topical local ester anesthetic used for relief of pain and itching, it acts by preventing transmission of impulses. Its duration of action lasts for about 10 minutes, once applied it diffuses into the nerve cells it binds to sodium channels. By binding to sodium channels it blocks the influx of sodium ions stopping the cells from depolarizing and conducting a nerve impulse. Benzocaine is broken down through ester hydrolysis into its resulting metabolites such as aminobenzoic acid, acetylbenzocaine and benzocaine hydroxylamine. Some adverse side effects that an individual may experience systemic toxicity syndrome, decreased cardiovascular function, decreased central nervous system function, cardiac complications and seizures. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: February 02, 2022 at 11:22 Last Updated: February 02, 2022 at 11:22
PW000398 View Pathway	drug action Benzocaine Action Pathway Homo sapiens Benzocaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Benzocaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. For this to happen, the sodium channel must first become active so that so that gating mechanism is in the open state. Therefore benzocaine preferentially inhibits neurons that are actively firing. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW145177 View Pathway	drug action Benzocaine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:14 Last Updated: October 07, 2023 at 15:14
PW145541 View Pathway	drug action Benzoic acid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:02 Last Updated: October 07, 2023 at 16:02
PW146740 View Pathway	drug action Benzoin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:55 Last Updated: October 07, 2023 at 18:55