PathWhiz

PathWhiz ID	Pathway	Meta Data
PW248225 View Pathway	metabolic Pyocyanine biosynthesis Pseudomonas aeruginosa Pyocyanin biosynthesis involves a sequence of enzymatic activities that occur within the bacterial cell. The precursor molecule for pyocyanin production, chorismate, is produced from major metabolic pathways within the bacterial cell, such as phenylalanine, tyrosine, and tryptophan biosynthesis. These precursors are enzymatically transformed to pyocyanin by a sequence of processes facilitated by particular enzymes, including phenazine biosynthesis proteins (PhzE,D, and F). These enzymes promote the condensation, cyclization, and oxidation events essential for the synthesis of pyocyanin, which plays an important role in the virulence and pathogenicity. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: May 17, 2024 at 13:23 Last Updated: May 17, 2024 at 13:23
PW294291 View Pathway	metabolic Pyocyanine biosynthesis to be deleted Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) Pyocyanin biosynthesis involves a sequence of enzymatic activities that occur within the bacterial cell. The precursor molecule for pyocyanin production, chorismate, is produced from major metabolic pathways within the bacterial cell, such as phenylalanine, tyrosine, and tryptophan biosynthesis. These precursors are enzymatically transformed to pyocyanin by a sequence of processes facilitated by particular enzymes, including phenazine biosynthesis proteins (PhzE,D, and F). These enzymes promote the condensation, cyclization, and oxidation events essential for the synthesis of pyocyanin, which plays an important role in the virulence and pathogenicity. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: September 09, 2024 at 11:56 Last Updated: September 09, 2024 at 11:56
PW132357 View Pathway	metabolic Pyrantel Drug Metabolism Homo sapiens Pyrantel is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Pyrantel passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:09 Last Updated: September 21, 2023 at 21:09
PW146272 View Pathway	drug action Pyrantel Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:50 Last Updated: October 07, 2023 at 17:50
PW144465 View Pathway	drug action Pyrazinamide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:41 Last Updated: October 07, 2023 at 13:41
PW128225 View Pathway	drug action Pyridostigmine Action Pathway Homo sapiens Pyridostigmine is a cholinesterase inhibitor used for the treatment of myasthenia gravis. It is usually administered intravenously and is very similar to neostigmine but with a less adverse effect profile and longer duration of action. The autoimmune disease known as myasthenia gravis is characterized defect of acetylcholine interacting at the neuromuscular junction. This results in muscle weakness, muscle loss and overall fatigue. Pyridostigmine inhibits the breakdown of acetylcholine allowing for an increase in activation and relieving the aforementioned symptoms. It specifically targets and inhibits acetylcholinesterase and cholinesterase, this increases extracellular levels of acetylcholine. Pyridostigmine is administered orally or intravenously, the latter having a better bioavailability. It is hydrolyzed in the blood by cholinesterases and in the liver by microsomal enzymes in the liver. Its main metabolite is 3-hydroxy-N-methyl-pyridinium and eliminated through the urine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 03, 2023 at 22:07 Last Updated: August 03, 2023 at 22:07
PW144663 View Pathway	drug action Pyridostigmine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:09 Last Updated: October 07, 2023 at 14:09
PW144262 View Pathway	drug action Pyridoxal phosphate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:03 Last Updated: October 07, 2023 at 13:03
PW000547 View Pathway	disease Pyridoxine Dependency with Seizures Homo sapiens The condition pyridoxine dependent-epilepsy is a condition that sees seizures beginning in infancy. In some cases, the seizures begin before birth. The seizures involve status epilepticus, which are seizures that last several minutes. The symptoms specific to pyridoxine dependent seizures can include hypothermia, dystonia and irritability right before an episode. They also include loss of consciousness, convulsions, and muscle rigidity. Rarely does this condition manifest between 1 to 3 years of age, although it has occured. Traditional anticonvulsant medication has proven ineffective in patients with this condition; patients are instead treated with pyridoxine daily in large doses. This compound is a b-vitamin found in food. Encephalopathy can occur if this condition is not treated, which can result in permanent brain damage. Although this condition is treated with pyridoxine, it can still cause neurological issues, such as learning disorders or developmental delay, regardless of treatment. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 29, 2013 at 10:39 Last Updated: August 29, 2013 at 10:39
PW121891 View Pathway	disease Pyridoxine Dependency with Seizures Mus musculus The condition pyridoxine dependent-epilepsy is a condition that sees seizures beginning in infancy. In some cases, the seizures begin before birth. The seizures involve status epilepticus, which are seizures that last several minutes. The symptoms specific to pyridoxine dependent seizures can include hypothermia, dystonia and irritability right before an episode. They also include loss of consciousness, convulsions, and muscle rigidity. Rarely does this condition manifest between 1 to 3 years of age, although it has occured. Traditional anticonvulsant medication has proven ineffective in patients with this condition; patients are instead treated with pyridoxine daily in large doses. This compound is a b-vitamin found in food. Encephalopathy can occur if this condition is not treated, which can result in permanent brain damage. Although this condition is treated with pyridoxine, it can still cause neurological issues, such as learning disorders or developmental delay, regardless of treatment. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:50 Last Updated: September 10, 2018 at 15:50