PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176499 View Pathway	metabolic Sarecycline Predicted Metabolism Pathway Homo sapiens Metabolites of Sarecycline are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 13, 2023 at 12:51 Last Updated: December 13, 2023 at 12:51
PW145705 View Pathway	drug action Saxagliptin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:26 Last Updated: October 07, 2023 at 16:26
PW123773 View Pathway	signaling Sayan Paul Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: January 24, 2020 at 05:54 Last Updated: January 24, 2020 at 05:54
PW128002 View Pathway	drug action Scopolamine Action Pathway Homo sapiens Scopolamine is a belladonna alkaloid with anticholinergic effects indicated for the treatment of nausea and vomiting associated with motion sickness and postoperative nausea and vomiting (PONV). It can be found under the brand names Donnatal, Phenohytro, and Transderm Scop. Acetylcholine (ACh) is a neurotransmitter that can signal through ligand-gated cation channels (nicotinic receptors) and G-protein-coupled muscarinic receptors (mAChRs). ACh signalling via mAChRs located in the central nervous system (CNS) and periphery can regulate smooth muscle contraction, glandular secretions, heart rate, and various neurological phenomena such as learning and memory. mAChRs can be divided into five subtypes, M1-M5, expressed at various levels throughout the brain. Also, M2 receptors are found in the heart and M3 receptors in smooth muscles, mediating effects apart from the direct modulation of the parasympathetic nervous system. While M1, M3, and M5 mAChRs primarily couple to Gq proteins to activate phospholipase C, M2 and M4 mainly couple to Gi/o proteins to inhibit adenylyl cyclase and modulate cellular ion flow. This system, in part, helps to control physiological responses such as nausea and vomiting. The significance of these observations to scopolamine's current therapeutic indications of preventing nausea and vomiting is unclear but is linked to its anticholinergic effect and ability to alter signalling through the CNS associated with vomiting. Possible side effects of using scopolamine may include disorientation, dry mouth, drowsiness, and sweating. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: June 28, 2023 at 12:33 Last Updated: June 28, 2023 at 12:33
PW144858 View Pathway	drug action Scopolamine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:34 Last Updated: October 07, 2023 at 14:34
PW176500 View Pathway	metabolic Scopolamine Predicted Metabolism Pathway Homo sapiens Metabolites of Scopolamine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 13, 2023 at 12:52 Last Updated: December 13, 2023 at 12:52
PW123941 View Pathway	signaling scos Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: June 19, 2020 at 04:39 Last Updated: June 19, 2020 at 04:39
PW122241 View Pathway	metabolic sddw Andro sffer BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: September 27, 2018 at 05:25 Last Updated: September 27, 2018 at 05:25
PW122250 View Pathway	metabolic sdfsfgsdfsd Myxococcus xanthus DK1622 BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 13, 2018 at 08:19 Last Updated: October 13, 2018 at 08:19
PW064750 View Pathway	signaling SDMA Signaling Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: May 31, 2018 at 10:39 Last Updated: May 31, 2018 at 10:39