PathWhiz ID | Pathway | Meta Data |
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PW145647View Pathway |
drug action
Sodium stibogluconate Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 16:17 Last Updated: October 07, 2023 at 16:17 |
PW146160View Pathway |
drug action
Sodium sulfate Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 17:33 Last Updated: October 07, 2023 at 17:33 |
PW146274View Pathway |
drug action
Sodium sulfide Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 17:50 Last Updated: October 07, 2023 at 17:50 |
PW132208View Pathway |
Sodium tartrate Drug MetabolismHomo sapiens
Sodium tartrate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Sodium tartrate passes through the liver and is then excreted from the body mainly through the kidney.
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Creator: Ray Kruger Created On: September 21, 2023 at 20:08 Last Updated: September 21, 2023 at 20:08 |
PW146668View Pathway |
drug action
Sodium tartrate Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 18:45 Last Updated: October 07, 2023 at 18:45 |
PW132282View Pathway |
Sodium tetradecyl sulfate Drug MetabolismHomo sapiens
Sodium tetradecyl sulfate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Sodium tetradecyl sulfate passes through the liver and is then excreted from the body mainly through the kidney.
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Creator: Ray Kruger Created On: September 21, 2023 at 20:36 Last Updated: September 21, 2023 at 20:36 |
PW144587View Pathway |
drug action
Sodium tetradecyl sulfate Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 13:57 Last Updated: October 07, 2023 at 13:57 |
PW146743View Pathway |
drug action
Sodium zirconium cyclosilicate Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 18:56 Last Updated: October 07, 2023 at 18:56 |
PW127736View Pathway |
drug action
Sofosbuvir Action PathwayHomo sapiens
Sofosbuvir is a direct-acting antiviral agent used to treat specific hepatitis C virus in combination with other anti-viral drugs
Hepatitis C virus lipoviroparticles enter target hepatocytes via receptor-mediated endocytosis. The lipoviroparticles attach to LDL-R and SR-B1, and then the virus binds to CD81 and subsequently claudin-1 and occludin, which mediate the late steps of viral entry. The virus is internalized by clathrin-dependent endocytosis. RNA is released from the mature Hepatitis C virion and translated at the rough endoplasmic reticulum into a single Genome polyprotein. The genome polyprotein is cleaved by host and viral proteases into 10 viral proteins. The nucleocapsid protein core and the two envelope proteins E1 and E2 form the N terminus of the polyprotein and are the structural components of HCV virions. The precursor also gives rise to the viroporin p7 and six non-structural (NS) proteins. Sofosbuvir is an inhibitor of the Hepatitis C Virus (HCV) Nonstructural protein 5B, which is an RNA-dependent RNA polymerase. RNA polymerase is required for viral RNA replication and assembly of HCV virions. By binding to nonstructural protein 5B outside of the active site of the enzyme, dasabuvir induces a conformational change. Viral RNA replication complexes localize to lipid raft-containing, detergent-resistant membranes created by the viral protein NS4B. For full viral replication and maturation, nonstructural protein 5B is required so viral RNA replication cannot occur. Envelope glycoproteins are acquired through budding into the endoplasmic reticulum lumen. The immature, non-infective virions are released via the cellular golgi apparatus.
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Creator: Ray Kruger Created On: May 29, 2023 at 16:19 Last Updated: May 29, 2023 at 16:19 |
PW145896View Pathway |
drug action
Sofosbuvir Drug Metabolism Action PathwayHomo sapiens
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Creator: Ray Kruger Created On: October 07, 2023 at 16:55 Last Updated: October 07, 2023 at 16:55 |