PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145460 View Pathway	drug action Solifenacin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:52 Last Updated: October 07, 2023 at 15:52
PW127978 View Pathway	drug action Solifenacin M3 Bladder Muscle Relaxation Action Pathway Homo sapiens Solifenacin is a muscarinic antagonist with antispasmodic properties used to treat urge urinary incontinence, urgency, and urinary frequency associated with an overactive bladder. It can be found under the brand name Vesicare. It has a long duration of action as it is usually taken once daily. Solifenacin is a competitive muscarinic receptor antagonist. Solifenacin's antagonism of the M3 receptor prevents contraction of the detrusor muscle, while antagonism of the M2 receptor may prevent contraction of smooth muscle in the bladder. Solifenacin works to decrease bladder activity by inhibiting contraction of the smooth muscle wall surrounding the bladder. As a potent and selective muscarinic receptor antagonist, solifenacin acts specifically at the M3 receptor site. Possible side effects of using solifenacin may include dry mouth, headache, dizziness, and vertigo. Solifenacine is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: June 26, 2023 at 12:12 Last Updated: June 26, 2023 at 12:12
PW176177 View Pathway	metabolic Solifenacin Predicted Metabolism Pathway new Homo sapiens Metabolites of Solifenacin are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 30, 2023 at 10:10 Last Updated: November 30, 2023 at 10:10
PW127941 View Pathway	drug action Solriamfetol Action Pathway Homo sapiens Solriamfetol, also known as Sunosi, is a dopamine and norepinephrine reuptake inhibitor (DNRI). This drug is indicated for the daytime treatment of sleepiness associated with narcolepsy or obstructive sleep apnea. Solriamfetol was given FDA approval in 2019. Solriamfetol weakly binds to dopamine and norepinephrine transporters but not serotonin transporters. Those transporters are called sodium-dependent dopamine transporter and sodium-dependent noradrenaline transporter. This makes more dopamine and noradrenaline available in the synapses of the brain. In consequence, the postsynaptic has more of those neurotransmitters available. Norepinephrine and dopamine are important neurotransmitters in sleep-wake regulation. This drug is available as oral tablets. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: June 21, 2023 at 12:22 Last Updated: June 21, 2023 at 12:22
PW146888 View Pathway	drug action Solriamfetol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:17 Last Updated: October 07, 2023 at 19:17
PW176232 View Pathway	metabolic Solriamfetol Predicted Metabolism Pathway Homo sapiens Metabolites of Solriamfetol are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 13:00 Last Updated: December 04, 2023 at 13:00
PW145978 View Pathway	drug action Somatostatin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:07 Last Updated: October 07, 2023 at 17:07
PW124340 View Pathway	metabolic Some path Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: November 12, 2020 at 19:10 Last Updated: November 12, 2020 at 19:10
PW122143 View Pathway	signaling Sonic Hedgehog (Shh) Mus musculus BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: September 13, 2018 at 20:35 Last Updated: September 13, 2018 at 20:35
PW091415 View Pathway	signaling Sonic Hedgehog (Shh) Pathway Homo sapiens Sonic hedgehog is a protein that in humans is encoded by the SHH ("sonic hedgehog") gene.[5] Both the gene and the protein may also be found notated alternatively as "Shh". Sonic hedgehog is one of three proteins in the mammalian signaling pathway family called hedgehog, the others being desert hedgehog (DHH) and Indian hedgehog (IHH). SHH is the best studied ligand of the hedgehog signaling pathway. It plays a key role in regulating vertebrate organogenesis, such as in the growth of digits on limbs and organization of the brain. Sonic hedgehog is the best established example of a morphogen as defined by Lewis Wolpert's French flag model—a molecule that diffuses to form a concentration gradient and has different effects on the cells of the developing embryo depending on its concentration. SHH remains important in the adult. It controls cell division of adult stem cells and has been implicated in the development of some cancers. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Aidin Foroutannaddafi Created On: August 14, 2018 at 21:44 Last Updated: August 14, 2018 at 21:44