PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128387 View Pathway	drug action Sulfisoxazole Action Pathway Escherichia coli (strain K12) Sulfisoxazole is a short-acting antibiotic from the sulfonamide drug class. It has activity against a wide range of gram-negative and gram-positive organisms. This drug is indicated in the treatment of many infections: urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, nocardiosis, chancroid, toxoplasmosis, malaria, and many others. This drug is bacteriostatic; it inhibits the replication of bacteria by inhibiting the dihydropteroate synthase. This enzyme is responsible for one of the reactions to synthesize folic acid in bacteria by the condensation of the pteridine with para-aminobenzoic acid (PABA). This drug stops the replication of the bacteria (bacteriostatic). Sulfisoxazole is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 25, 2023 at 12:43 Last Updated: August 25, 2023 at 12:43
PW144392 View Pathway	drug action Sulfisoxazole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:33 Last Updated: October 07, 2023 at 13:33
PW122077 View Pathway	disease Sulfite Oxidase Deficiency Rattus norvegicus Sulfite oxidase deficiency (SOD) is a disorder, an autosomal recessive disease. In classic SOD, it is usually identified a few days after the birth of an affected individual, and is recognizable through characteristic dysmorphic features, seizures, and other signs of progressive encephalopathy. Patients also have ocular lenses that are dislocated, and usually die within a few months of being born. In late- onset SOD, the disorder is identified only in the later months, usually 6-18 months, of the child’s life by a delay or regression of neurological progress. This disorder is very rare, but the actual prevalence is not known. It can be diagnosed through a sulfite test strip in urine or by a skin fibroblast culture, which will indicate an absence of sulfite oxidase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:52 Last Updated: September 10, 2018 at 15:52
PW121853 View Pathway	disease Sulfite Oxidase Deficiency Mus musculus Sulfite oxidase deficiency (SOD) is a disorder, an autosomal recessive disease. In classic SOD, it is usually identified a few days after the birth of an affected individual, and is recognizable through characteristic dysmorphic features, seizures, and other signs of progressive encephalopathy. Patients also have ocular lenses that are dislocated, and usually die within a few months of being born. In late- onset SOD, the disorder is identified only in the later months, usually 6-18 months, of the child’s life by a delay or regression of neurological progress. This disorder is very rare, but the actual prevalence is not known. It can be diagnosed through a sulfite test strip in urine or by a skin fibroblast culture, which will indicate an absence of sulfite oxidase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:50 Last Updated: September 10, 2018 at 15:50
PW127276 View Pathway	disease Sulfite Oxidase Deficiency Homo sapiens Sulfite oxidase deficiency (SOD) is a disorder, an autosomal recessive disease. In classic SOD, it is usually identified a few days after the birth of an affected individual, and is recognizable through characteristic dysmorphic features, seizures, and other signs of progressive encephalopathy. Patients also have ocular lenses that are dislocated, and usually die within a few months of being born. In late- onset SOD, the disorder is identified only in the later months, usually 6-18 months, of the child’s life by a delay or regression of neurological progress. This disorder is very rare, but the actual prevalence is not known. It can be diagnosed through a sulfite test strip in urine or by a skin fibroblast culture, which will indicate an absence of sulfite oxidase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: November 28, 2022 at 11:50 Last Updated: November 28, 2022 at 11:50
PW000508 View Pathway	disease Sulfite Oxidase Deficiency Homo sapiens Sulfite oxidase deficiency (SOD) is a disorder, an autosomal recessive disease. In classic SOD, it is usually identified a few days after the birth of an affected individual, and is recognizable through characteristic dysmorphic features, seizures, and other signs of progressive encephalopathy. Patients also have ocular lenses that are dislocated, and usually die within a few months of being born. In late- onset SOD, the disorder is identified only in the later months, usually 6-18 months, of the child’s life by a delay or regression of neurological progress. This disorder is very rare, but the actual prevalence is not known. It can be diagnosed through a sulfite test strip in urine or by a skin fibroblast culture, which will indicate an absence of sulfite oxidase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 29, 2013 at 10:39 Last Updated: August 29, 2013 at 10:39
PW128466 View Pathway	drug action Sulfoxone Action Pathway Mycobacterium leprae Sulfoxone, also known as aldesulfone sodium, is a sulfonamide antibiotic with bacteriostatic activity. It is indicated in the treatment of leprosy and dermatitis herpetiformis. Leprosy is caused by Mycobacterium leprae. Sulfoxone inhibits the growth of the bacteria by inhibiting competitively the dihydropteroate synthase enzyme. This results in the inability to bind the substrate, para-aminobenzoic acid (PABA) resulting in the inability of the bacteria to do the synthesis of folic acid. Without folic acid, the bacteria can not grow because it can not produce DNA anymore. Right now this drug has been discontinued. It is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 30, 2023 at 09:34 Last Updated: August 30, 2023 at 09:34
PW145233 View Pathway	drug action Sulfoxone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:22 Last Updated: October 07, 2023 at 15:22
PW176425 View Pathway	metabolic Sulfoxone Predicted Metabolism Pathway Homo sapiens Metabolites of Sulfoxone are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 08, 2023 at 13:51 Last Updated: December 08, 2023 at 13:51
PW146234 View Pathway	drug action Sulfur hexafluoride Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:44 Last Updated: October 07, 2023 at 17:44