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PW127014

Pw127014 View Pathway
metabolic

Biosynthesis of type II polyketide backbone 1655806275

Bacteria
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ng Ngashangva

Created On: June 21, 2022 at 04:11

Last Updated: June 21, 2022 at 04:11

PW127015

Pw127015 View Pathway
metabolic

Biosynthesis of type II polyketide backbone 1655806835

Bacteria
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ng Ngashangva

Created On: June 21, 2022 at 04:21

Last Updated: June 21, 2022 at 04:21

PW127016

Pw127016 View Pathway
metabolic

Biosynthesis of type II polyketide backbone 1655806835

Paenibacillus peoriae IBSD35
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Ng Ngashangva

Created On: June 21, 2022 at 04:22

Last Updated: June 21, 2022 at 04:22

PW123902

Pw123902 View Pathway
metabolic

Biosynthesis of Type II Polyketide Products

Streptomyces glaucescens
Polyketides are a large group of bioactive secondary metabolites with various biological activities that arise from the diversity in its structures from the precursors of alternating groups like carbonyl and methylene. For this reason, they have a high value in pharmaceutical properties. They are primarily divided into three types: type I, type II and type III polyketides. This pathway focuses on the biosynthesis of type II polyketide products (from the biosynthesis of type II polyketide backbone) which are often based on aromatic molecules produced iteratively by the action of dissociated enzymes in the bacterial species Streptomyces glaucescens. This pathway shows the production of tetracenomycin C and 8-demethyl-tetracenomycin starting from 9,14-decaketides by the action of tcmI, tcmH, tcmN, tcmP, tcmG and tcmO gene proteins. Via a series of reactions using polyketide-synthase, hydroxylase and other enzymes shown in this illustration, the formation of tetracenomycin C occurs. It must be noted that 8-demethyl-tetracenomycin is a derivative of tetracenomycin-C (both shown to be stemming from tetracenomycin-B3) and acts as a teracenomycin having the similar bacterial metabolite role as tetracenomycin-C.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Aadhavya Sivakumaran

Created On: May 29, 2020 at 11:35

Last Updated: May 29, 2020 at 11:35

PW002403

Pw002403 View Pathway
metabolic

Biosynthesis of Unsaturated Fatty Acids

Saccharomyces cerevisiae
The biosynthesis of unsaturated fatty acids begins with palmitic acid interacting with ATP and Coenzyme A through an acyl-CoA synthetase resulting in the release of AMP, diphosphate and palmitoyl-CoA. This compound then enters the cycle of unsaturated fatty acid elongation This cycle starts with the acyl-CoA reacting with a hydrogen ion and a malonyl-CoA through a 3-oxo-stearoyl-CoA synthase resulting in the release of a coenzyme A, a carbon dioxide molecule and a 3-oxoacyl-CoA. The 3-oxoacyl-CoA then reacts with a hydrogen ion and an NADPH through a 3-oxoacyl-CoA reductase resulting in the release of an NADP and a (3R)-3-hydroxy-acyl-CoA. The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. This compound then reacts with a hydrogen ion and an NADPH through an enoyl-CoA reductase resulting in the release of a NADP and a new acyl-CoA. The cycle goes from palmitoyl-CoA-->stearoyl-CoA-->eicosanoyl-CoA-->docosanoyl-CoA-->tetracosanoyl-CoA-->hexacosanoyl-CoA. The long-chain fatty acids are then incorporated into the sphingolipid pathway. The long-chain fatty acid reacts with a phytosphingosine through a ceramide synthase resulting in the release of a hydrogen ion, a coenzyme A, and an N-acyl-phytosphinganine.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: miguel ramirez

Created On: January 07, 2016 at 16:14

Last Updated: January 07, 2016 at 16:14

PW002408

Pw002408 View Pathway
metabolic

Biosynthesis of Unsaturated Fatty Acids (Docosanoyl-CoA)

Saccharomyces cerevisiae
The biosynthesis of unsaturated fatty acids begins with palmitic acid interacting with ATP and Coenzyme A through an acyl-CoA synthetase resulting in the release of AMP, diphosphate and palmitoyl-CoA. This compound then enters the cycle of unsaturated fatty acid elongation This cycle starts with the acyl-CoA reacting with a hydrogen ion and a malonyl-CoA through a 3-oxo-stearoyl-CoA synthase resulting in the release of a coenzyme A, a carbon dioxide molecule and a 3-oxoacyl-CoA. The 3-oxoacyl-CoA then reacts with a hydrogen ion and an NADPH through a 3-oxoacyl-CoA reductase resulting in the release of an NADP and a (3R)-3-hydroxy-acyl-CoA. The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. This compound then reacts with a hydrogen ion and a NADPH through a enoyl-CoA reductase resulting in the release of a NADP and a new acyl-CoA. The cycle goes from palmitoyl-CoA-->stearoyl-CoA-->eicosanoyl-CoA-->docosanoyl-CoA-->tetracosanoyl-CoA-->hexacosanoyl-CoA. The long chain fatty acids are then incorporated into the sphingolipid pathway. The long chain fatty acid reacts with a phytosphingosine through a ceramide synthase resulting in the release of a hydrogen ion, a coenzyme A and a N-acyl-phytosphinganine.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: miguel ramirez

Created On: January 13, 2016 at 10:43

Last Updated: January 13, 2016 at 10:43

PW002434

Pw002434 View Pathway
metabolic

Biosynthesis of Unsaturated Fatty Acids (Icosanoyl-CoA)

Saccharomyces cerevisiae
The biosynthesis of unsaturated fatty acids begins with palmitic acid interacting with ATP and Coenzyme A through an acyl-CoA synthetase resulting in the release of AMP, diphosphate and palmitoyl-CoA. This compound then enters the cycle of unsaturated fatty acid elongation This cycle starts with the acyl-CoA reacting with a hydrogen ion and a malonyl-CoA through a 3-oxo-stearoyl-CoA synthase resulting in the release of a coenzyme A, a carbon dioxide molecule and a 3-oxoacyl-CoA. The 3-oxoacyl-CoA then reacts with a hydrogen ion and an NADPH through a 3-oxoacyl-CoA reductase resulting in the release of an NADP and a (3R)-3-hydroxy-acyl-CoA. The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. This compound then reacts with a hydrogen ion and a NADPH through a enoyl-CoA reductase resulting in the release of a NADP and a new acyl-CoA. The cycle goes from palmitoyl-CoA-->stearoyl-CoA-->eicosanoyl-CoA-->docosanoyl-CoA-->tetracosanoyl-CoA-->hexacosanoyl-CoA. The long chain fatty acids are then incorporated into the sphingolipid pathway. The long chain fatty acid reacts with a phytosphingosine through a ceramide synthase resulting in the release of a hydrogen ion, a coenzyme A and a N-acyl-phytosphinganine.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: miguel ramirez

Created On: January 28, 2016 at 10:17

Last Updated: January 28, 2016 at 10:17

PW002435

Pw002435 View Pathway
metabolic

Biosynthesis of Unsaturated Fatty Acids (Stearoyl-CoA)

Saccharomyces cerevisiae
The biosynthesis of unsaturated fatty acids begins with palmitic acid interacting with ATP and Coenzyme A through an acyl-CoA synthetase resulting in the release of AMP, diphosphate and palmitoyl-CoA. This compound then enters the cycle of unsaturated fatty acid elongation This cycle starts with the acyl-CoA reacting with a hydrogen ion and a malonyl-CoA through a 3-oxo-stearoyl-CoA synthase resulting in the release of a coenzyme A, a carbon dioxide molecule and a 3-oxoacyl-CoA. The 3-oxoacyl-CoA then reacts with a hydrogen ion and an NADPH through a 3-oxoacyl-CoA reductase resulting in the release of an NADP and a (3R)-3-hydroxy-acyl-CoA. The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. This compound then reacts with a hydrogen ion and a NADPH through a enoyl-CoA reductase resulting in the release of a NADP and a new acyl-CoA. The cycle goes from palmitoyl-CoA-->stearoyl-CoA-->eicosanoyl-CoA-->docosanoyl-CoA-->tetracosanoyl-CoA-->hexacosanoyl-CoA. The long chain fatty acids are then incorporated into the sphingolipid pathway. The long chain fatty acid reacts with a phytosphingosine through a ceramide synthase resulting in the release of a hydrogen ion, a coenzyme A and a N-acyl-phytosphinganine.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: miguel ramirez

Created On: January 28, 2016 at 11:44

Last Updated: January 28, 2016 at 11:44

PW002404

Pw002404 View Pathway
metabolic

Biosynthesis of Unsaturated Fatty Acids (Tetracosanoyl-CoA)

Saccharomyces cerevisiae
The biosynthesis of unsaturated fatty acids begins with palmitic acid interacting with ATP and Coenzyme A through an acyl-CoA synthetase resulting in the release of AMP, diphosphate and palmitoyl-CoA. This compound then enters the cycle of unsaturated fatty acid elongation This cycle starts with the acyl-CoA reacting with a hydrogen ion and a malonyl-CoA through a 3-oxo-stearoyl-CoA synthase resulting in the release of a coenzyme A, a carbon dioxide molecule and a 3-oxoacyl-CoA. The 3-oxoacyl-CoA then reacts with a hydrogen ion and an NADPH through a 3-oxoacyl-CoA reductase resulting in the release of an NADP and a (3R)-3-hydroxy-acyl-CoA. The resulting compound then reacts with a trans-2-enoyl-CoA hydratase 2 resulting in the release of water and trans-2,3-dehydroacyl-CoA. This compound then reacts with a hydrogen ion and a NADPH through a enoyl-CoA reductase resulting in the release of a NADP and a new acyl-CoA. The cycle goes from palmitoyl-CoA-->stearoyl-CoA-->eicosanoyl-CoA-->docosanoyl-CoA-->tetracosanoyl-CoA-->hexacosanoyl-CoA. The long chain fatty acids are then incorporated into the sphingolipid pathway. The long chain fatty acid reacts with a phytosphingosine through a ceramide synthase resulting in the release of a hydrogen ion, a coenzyme A and a N-acyl-phytosphinganine.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: miguel ramirez

Created On: January 12, 2016 at 11:33

Last Updated: January 12, 2016 at 11:33

PW124586

Pw124586 View Pathway
metabolic

Biosíntesis de colesterol

human
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Valeria Becerril

Created On: March 17, 2021 at 22:30

Last Updated: March 17, 2021 at 22:30