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Pathways

PathWhiz ID Pathway Meta Data

PW012863

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signaling

A20 mechanism pathway

Homo sapiens

PW128481

Pw128481 View Pathway
drug action

a Action Pathway

Homo sapiens
Human thrombin is a platelet-activating factor also known under the brand names Artiss, Evarrest, Evicel, Evithrom, Tachosil, Tisseel and Vistaseal. Human thrombin is purified human thrombin, a highly specific serine protease that acts on fibrinogen to fibrin, leading to the formation of a blood clot. It also acts on coagulation factor XIII to activate it and establish cross-linking of fibrin producing a clot. It is used as a topical application to a surgical site to minimize bleeding. Human thrombin is metabolized the same way as endogenous thrombin, inactivated by plasma inhibitors.

PW122161

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physiological

a

Andrographolide

PW064708

Pw064708 View Pathway
disease

a

Bacteria

PW124259

Pw124259 View Pathway
protein

a

Homo sapiens

PW146992

Pw146992 View Pathway
metabolic

9-cis-Retinoic acid Drug Metabolism Pathway

Homo sapiens

PW121923

Pw121923 View Pathway
disease

5-Oxoprolinuria

Rattus norvegicus
5-Oxoprolinuria (5-Oxoprolinase deficiency) is a result of a defect in the gamma-glutamyl cycle due to either 5-oxoprolinase or glutathione synthetase deficiency. In the case of glutathione synthetase deficiency, the glycine is not incorporated into gamma-glutamylcysteine. In the case of 5-oxoprolinase, however, pyroglutamic acid accumulates. Symptoms include anemia, mental retardation, metabolic acidosis, respiratory distress and urolithiasis.

PW000074

Pw000074 View Pathway
disease

5-Oxoprolinuria

Homo sapiens
5-Oxoprolinuria (5-Oxoprolinase deficiency) is a result of a defect in the gamma-glutamyl cycle due to either 5-oxoprolinase or glutathione synthetase deficiency. In the case of glutathione synthetase deficiency, the glycine is not incorporated into gamma-glutamylcysteine. In the case of 5-oxoprolinase, however, pyroglutamic acid accumulates. Symptoms include anemia, mental retardation, metabolic acidosis, respiratory distress and urolithiasis.

PW127179

Pw127179 View Pathway
disease

5-Oxoprolinuria

Homo sapiens
5-Oxoprolinuria (5-Oxoprolinase deficiency) is a result of a defect in the gamma-glutamyl cycle due to either 5-oxoprolinase or glutathione synthetase deficiency. In the case of glutathione synthetase deficiency, the glycine is not incorporated into gamma-glutamylcysteine. In the case of 5-oxoprolinase, however, pyroglutamic acid accumulates. Symptoms include anemia, mental retardation, metabolic acidosis, respiratory distress and urolithiasis.

PW121697

Pw121697 View Pathway
disease

5-Oxoprolinuria

Mus musculus
5-Oxoprolinuria (5-Oxoprolinase deficiency) is a result of a defect in the gamma-glutamyl cycle due to either 5-oxoprolinase or glutathione synthetase deficiency. In the case of glutathione synthetase deficiency, the glycine is not incorporated into gamma-glutamylcysteine. In the case of 5-oxoprolinase, however, pyroglutamic acid accumulates. Symptoms include anemia, mental retardation, metabolic acidosis, respiratory distress and urolithiasis.