PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128383 View Pathway	drug action Dosulepin Serotonin antagonist Action Pathway Homo sapiens Dosulepin is indicated in the treatment of symptoms of depressive illness, especially where an anti-anxiety effect is required. Dosulepin displays affinity towards α2-adrenoceptors and to a lesser extent, α1-adrenoceptors. Inhibition of presynaptic α2-adrenoceptors by dosulepin facilitates noradrenaline release and further potentiates the antidepressant effects. It also downregulates central β-adrenoceptors by causing a decline in the number of receptors and reduces noradrenaline-induced cyclic AMP formation. Dosulepin binds to 5HT1A and 5HT2A receptors in the cerebral cortex and hippocampus as an antagonist. 5HT1A receptors are autoreceptors that inhibit 5HT release and 5HT2A receptors are Gi/Go-coupled receptors that reduces dopamine release upon activation. Antagonism at 5HT2A receptors may also improve sleep patterns. Dosulepin also binds to muscarinic acetylcholine receptors and causes antimuscarinic side effects such as dry mouth. By acting as an antagonist at histamine type 1 (H1) receptors, dosulepin mediates a sedative effect. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 25, 2023 at 11:16 Last Updated: August 25, 2023 at 11:16
PW128215 View Pathway	drug action Donepezil Action Pathway Homo sapiens Donepezil is an acetylcholinesterase inhibitor also known as Adlarity, Aricept and Namzaric, that is used in the treatment of Alzheimer's Disease and dementia. It is administered orally or transdermally, sometimes in combination with memantine in order to treat moderate to severe dementia. Donepezil selectively inhibits the acetylcholinesterase enzyme, by doing so it is believed to enhance cholinergic transmission to relieve the symptoms of Alzheimer's and dementia. Normally acetylcholinesterase breaks down acetylcholine, this inhibited its enhances cholinergic transmission. Donepezil goes through first-pass metabolism by CYP3A4 and CYP2D6 into metabolites which can be further broken down by dealkylation, hydroxylation, oxidation, hydrolysis and glucuronidation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 03, 2023 at 13:54 Last Updated: August 03, 2023 at 13:54
PW128196 View Pathway	drug action Donepezil Acetylcholinesterase Inhibitor Action Pathway Homo sapiens Donepezil is an acetylcholinesterase inhibitor that is used in the treatment of Alzheimer's Disease and dementia. It is administered orally or transdermally, sometimes in combination with memantine in order to treat moderate to severe dementia. Donepezil selectively inhibits the acetylcholinesterase enzyme, by doing so it is believed to enhance cholinergic transmission to relieve the symptoms of Alzheimer and dementia. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Anaya Created On: August 01, 2023 at 11:50 Last Updated: August 01, 2023 at 11:50
PW128386 View Pathway	drug action Dolasetron Serotonin antagonist Action Pathway Homo sapiens Dolasetron is a selective serotonin 5-HT3 receptor antagonist. In vivo, the drug is rapidly converted into its major active metabolite, hydrodolasetron, which seems to be largely responsible for the drug's pharmacological activity. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 25, 2023 at 12:02 Last Updated: August 25, 2023 at 12:02
PW124234 View Pathway	metabolic chebulagic acid Metabolism 1602981862 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 17, 2020 at 18:44 Last Updated: October 17, 2020 at 18:44
PW124232 View Pathway	metabolic chebulagic acid Metabolism 1602980507 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 17, 2020 at 18:21 Last Updated: October 17, 2020 at 18:21
PW124219 View Pathway	physiological chebulagic acid Metabolism 1602639807 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 13, 2020 at 19:43 Last Updated: October 13, 2020 at 19:43
PW123825 View Pathway	signaling chebulagic acid Metabolism 1582757459 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: February 26, 2020 at 15:51 Last Updated: February 26, 2020 at 15:51
PW123807 View Pathway	signaling chebulagic acid Metabolism 1581839290 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: February 16, 2020 at 00:48 Last Updated: February 16, 2020 at 00:48
PW123794 View Pathway	signaling chebulagic acid Metabolism 1581167212 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: February 08, 2020 at 06:07 Last Updated: February 08, 2020 at 06:07