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PW000053

Pw000053 View Pathway
metabolic

Vitamin B6 Metabolism

Homo sapiens
As is commonly known there are many vitamins, the vitamin B complex group being one of the most well known. An important vitamin B complex group vitamin is vitamin B6, which is water-soluble. Moreover, this vitamin comes in various forms, one of which is an active form, known by the name pyridoxal phosphate or PLP. PLP serves as cofactor in a variety of reactions including from amino acid metabolism, (in particular in reactions such as transamination, deamination, and decarboxylation). To complicate matters however, there are in fact seven alternate forms of this same vitamin. These include pyridoxine (PN), pyridoxine 5’-phosphate (PNP), pyridoxal (PL), pyridoxamine (PM), pyridoxamine 5’-phosphate (PMP), 4-pyridoxic acid (PA), and the aforementioned pyridoxal 5’-phosphate (PLP). One of these forms, PA, is in fact a catabolite whose presence is found in excreted urine. For a person to absorb some of these active forms of vitamin B6 such as PLP or PMP they must first be dephosphorylized. This done via an alkaline enzyme phosphatase. There are a wide variety of biproducts from the metabolism in question, most of which find there ways into the urine and from there are excreted. One such biproduct is 4-pyridoxic acid. In fact this last biproduct is found in such large quantities that estimates of vitamin B6 metabolism birproducts show that 4-pyridoxic acid is as much as 40-60% of all the biproducts.Of course, it is not the only product of metabolism. Others include,include pyridoxal, pyridoxamine, and pyridoxine.
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Creator: WishartLab

Created On: August 01, 2013 at 13:54

Last Updated: August 01, 2013 at 13:54

PW088414

Pw088414 View Pathway
metabolic

Vitamin B6 Metabolism

Drosophila melanogaster
As is commonly known there are many vitamins, the vitamin B complex group being one of the most well known. An important vitamin B complex group vitamin is vitamin B6, which is water-soluble. Moreover, this vitamin comes in various forms, one of which is an active form, known by the name pyridoxal phosphate or PLP. PLP serves as cofactor in a variety of reactions including from amino acid metabolism, (in particular in reactions such as transamination, deamination, and decarboxylation). To complicate matters however, there are in fact seven alternate forms of this same vitamin. These include pyridoxine (PN), pyridoxine 5’-phosphate (PNP), pyridoxal (PL), pyridoxamine (PM), pyridoxamine 5’-phosphate (PMP), 4-pyridoxic acid (PA), and the aforementioned pyridoxal 5’-phosphate (PLP). One of these forms, PA, is in fact a catabolite whose presence is found in excreted urine. For a person to absorb some of these active forms of vitamin B6 such as PLP or PMP they must first be dephosphorylized. This done via an alkaline enzyme phosphatase. There are a wide variety of biproducts from the metabolism in question, most of which find there ways into the urine and from there are excreted. One such biproduct is 4-pyridoxic acid. In fact this last biproduct is found in such large quantities that estimates of vitamin B6 metabolism birproducts show that 4-pyridoxic acid is as much as 40-60% of all the biproducts.Of course, it is not the only product of metabolism. Others include,include pyridoxal, pyridoxamine, and pyridoxine.
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Creator: Ana Marcu

Created On: August 10, 2018 at 15:58

Last Updated: August 10, 2018 at 15:58

PW534949

Pw534949 View Pathway
metabolic

Vitamin B6 Metabolism

Pseudomonas stutzeri A1501
Vitamin B6 metabolism in bacteria involves the biosynthesis and utilization of various forms of Vitamin B6, primarily pyridoxal 5'-phosphate (PLP), the active form of the vitamin. Bacteria can synthesize Vitamin B6 through two main pathways: the de novo DXP-independent pathway (pyridoxal phosphate biosynthesis I) and the DXP-dependent pathway. In the de novo pathway, key enzymes like Pdx1 and Pdx2 convert intermediates into pyridoxine 5'-phosphate (PNP), which is then oxidized to PLP by the enzyme pyridoxine phosphate oxidase (PdxH). PLP acts as a cofactor for various enzymes involved in amino acid metabolism, including transaminases, decarboxylases, and racemases.Bacteria rely on PLP for critical cellular processes, including amino acid metabolism, stress response, and protection against oxidative damage.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: February 20, 2025 at 10:59

Last Updated: February 20, 2025 at 10:59

PW533838

Pw533838 View Pathway
metabolic

Vitamin B6 Metabolism

Xanthomonas campestris
Vitamin B6 metabolism in bacteria involves the biosynthesis and utilization of various forms of Vitamin B6, primarily pyridoxal 5'-phosphate (PLP), the active form of the vitamin. Bacteria can synthesize Vitamin B6 through two main pathways: the de novo DXP-independent pathway (pyridoxal phosphate biosynthesis I) and the DXP-dependent pathway. In the de novo pathway, key enzymes like Pdx1 and Pdx2 convert intermediates into pyridoxine 5'-phosphate (PNP), which is then oxidized to PLP by the enzyme pyridoxine phosphate oxidase (PdxH). PLP acts as a cofactor for various enzymes involved in amino acid metabolism, including transaminases, decarboxylases, and racemases.Bacteria rely on PLP for critical cellular processes, including amino acid metabolism, stress response, and protection against oxidative damage.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: February 20, 2025 at 03:26

Last Updated: February 20, 2025 at 03:26

PW536471

Pw536471 View Pathway
metabolic

Vitamin B6 Metabolism

Vibrio fluvialis I21563
Vitamin B6 metabolism in bacteria involves the biosynthesis and utilization of various forms of Vitamin B6, primarily pyridoxal 5'-phosphate (PLP), the active form of the vitamin. Bacteria can synthesize Vitamin B6 through two main pathways: the de novo DXP-independent pathway (pyridoxal phosphate biosynthesis I) and the DXP-dependent pathway. In the de novo pathway, key enzymes like Pdx1 and Pdx2 convert intermediates into pyridoxine 5'-phosphate (PNP), which is then oxidized to PLP by the enzyme pyridoxine phosphate oxidase (PdxH). PLP acts as a cofactor for various enzymes involved in amino acid metabolism, including transaminases, decarboxylases, and racemases.Bacteria rely on PLP for critical cellular processes, including amino acid metabolism, stress response, and protection against oxidative damage.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: February 21, 2025 at 03:48

Last Updated: February 21, 2025 at 03:48

PW536154

Pw536154 View Pathway
metabolic

Vitamin B6 Metabolism

Raoultella planticola ATCC 33531
Vitamin B6 metabolism in bacteria involves the biosynthesis and utilization of various forms of Vitamin B6, primarily pyridoxal 5'-phosphate (PLP), the active form of the vitamin. Bacteria can synthesize Vitamin B6 through two main pathways: the de novo DXP-independent pathway (pyridoxal phosphate biosynthesis I) and the DXP-dependent pathway. In the de novo pathway, key enzymes like Pdx1 and Pdx2 convert intermediates into pyridoxine 5'-phosphate (PNP), which is then oxidized to PLP by the enzyme pyridoxine phosphate oxidase (PdxH). PLP acts as a cofactor for various enzymes involved in amino acid metabolism, including transaminases, decarboxylases, and racemases.Bacteria rely on PLP for critical cellular processes, including amino acid metabolism, stress response, and protection against oxidative damage.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: February 21, 2025 at 00:30

Last Updated: February 21, 2025 at 00:30

PW686645

Pw686645 View Pathway
metabolic

Vitamin B6 Metabolism

Escherichia albertii KF1
Vitamin B6 metabolism in bacteria involves the biosynthesis and utilization of various forms of Vitamin B6, primarily pyridoxal 5'-phosphate (PLP), the active form of the vitamin. Bacteria can synthesize Vitamin B6 through two main pathways: the de novo DXP-independent pathway (pyridoxal phosphate biosynthesis I) and the DXP-dependent pathway. In the de novo pathway, key enzymes like Pdx1 and Pdx2 convert intermediates into pyridoxine 5'-phosphate (PNP), which is then oxidized to PLP by the enzyme pyridoxine phosphate oxidase (PdxH). PLP acts as a cofactor for various enzymes involved in amino acid metabolism, including transaminases, decarboxylases, and racemases.Bacteria rely on PLP for critical cellular processes, including amino acid metabolism, stress response, and protection against oxidative damage.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: February 20, 2025 at 23:44

Last Updated: February 20, 2025 at 23:44

PW536130

Pw536130 View Pathway
metabolic

Vitamin B6 Metabolism

Escherichia sp. 1_1_43
Vitamin B6 metabolism in bacteria involves the biosynthesis and utilization of various forms of Vitamin B6, primarily pyridoxal 5'-phosphate (PLP), the active form of the vitamin. Bacteria can synthesize Vitamin B6 through two main pathways: the de novo DXP-independent pathway (pyridoxal phosphate biosynthesis I) and the DXP-dependent pathway. In the de novo pathway, key enzymes like Pdx1 and Pdx2 convert intermediates into pyridoxine 5'-phosphate (PNP), which is then oxidized to PLP by the enzyme pyridoxine phosphate oxidase (PdxH). PLP acts as a cofactor for various enzymes involved in amino acid metabolism, including transaminases, decarboxylases, and racemases.Bacteria rely on PLP for critical cellular processes, including amino acid metabolism, stress response, and protection against oxidative damage.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: February 21, 2025 at 00:09

Last Updated: February 21, 2025 at 00:09

PW533302

Pw533302 View Pathway
metabolic

Vitamin B6 Metabolism

Escherichia coli O157:H7
Vitamin B6 metabolism in bacteria involves the biosynthesis and utilization of various forms of Vitamin B6, primarily pyridoxal 5'-phosphate (PLP), the active form of the vitamin. Bacteria can synthesize Vitamin B6 through two main pathways: the de novo DXP-independent pathway (pyridoxal phosphate biosynthesis I) and the DXP-dependent pathway. In the de novo pathway, key enzymes like Pdx1 and Pdx2 convert intermediates into pyridoxine 5'-phosphate (PNP), which is then oxidized to PLP by the enzyme pyridoxine phosphate oxidase (PdxH). PLP acts as a cofactor for various enzymes involved in amino acid metabolism, including transaminases, decarboxylases, and racemases.Bacteria rely on PLP for critical cellular processes, including amino acid metabolism, stress response, and protection against oxidative damage.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: February 19, 2025 at 23:32

Last Updated: February 19, 2025 at 23:32

PW686621

Pw686621 View Pathway
metabolic

Vitamin B6 Metabolism

Escherichia coli (strain K12 / MC4100 / BW2952)
Vitamin B6 metabolism in bacteria involves the biosynthesis and utilization of various forms of Vitamin B6, primarily pyridoxal 5'-phosphate (PLP), the active form of the vitamin. Bacteria can synthesize Vitamin B6 through two main pathways: the de novo DXP-independent pathway (pyridoxal phosphate biosynthesis I) and the DXP-dependent pathway. In the de novo pathway, key enzymes like Pdx1 and Pdx2 convert intermediates into pyridoxine 5'-phosphate (PNP), which is then oxidized to PLP by the enzyme pyridoxine phosphate oxidase (PdxH). PLP acts as a cofactor for various enzymes involved in amino acid metabolism, including transaminases, decarboxylases, and racemases.Bacteria rely on PLP for critical cellular processes, including amino acid metabolism, stress response, and protection against oxidative damage.
BioPAX SVG SBGN SBML PWML All files (.zip)

Creator: Julia Wakoli

Created On: February 19, 2025 at 22:28

Last Updated: February 19, 2025 at 22:28