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Pathways

PathWhiz ID Pathway Meta Data

PW146115

Pw146115 View Pathway
drug action

Polyestradiol phosphate Drug Metabolism Action Pathway

Homo sapiens

PW146276

Pw146276 View Pathway
drug action

Polyethylene glycol 300 Drug Metabolism Action Pathway

Homo sapiens

PW146218

Pw146218 View Pathway
drug action

Polyethylene glycol 400 Drug Metabolism Action Pathway

Homo sapiens

PW146071

Pw146071 View Pathway
drug action

Polyethylene glycol Drug Metabolism Action Pathway

Homo sapiens

PW125886

Pw125886 View Pathway
metabolic

Polyhydroxyalkanoates

Bacteria
This metabolic pathway contains the 3 important pathways

PW124456

Pw124456 View Pathway
metabolic

polyhydroxyalkanoates synthesis

Bacteria

PW122263

Pw122263 View Pathway
metabolic

Polyketide type II Biosynthesis

Bacteria
Polyketides are a large family of natural products found in bacteria, fungi and plants, and include many clinically important drugs such as tetracycline, daunorubicin, erythromycin, rapamycin and lovastatin. They are biosynthesized from acyl CoA precursors by polyketide synthases (PKSs).

PW147044

Pw147044 View Pathway
metabolic

Polymyxin B Sulfate Drug Metabolism Pathway

Homo sapiens

PW002052

Pw002052 View Pathway
metabolic

Polymyxin Resistance

Escherichia coli
UDP-glucuronic acid compound undergoes a NAD dependent reaction through a bifunctional polymyxin resistance protein to produce UDP-Beta-L-threo-pentapyranos-4-ulose. This compound then reacts with L-glutamic acid through a UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase to produce an oxoglutaric acid and UDP-4-amino-4-deoxy-beta-L-arabinopyranose The latter compound interacts with a N10-formyl-tetrahydrofolate through a bifunctional polymyxin resistance protein ArnA, resulting in a tetrahydrofolate, a hydrogen ion and a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose, which in turn reacts with a product of the methylerythritol phosphate and polysoprenoid biosynthesis pathway, di-trans,octa-cis-undecaprenyl phosphate to produce a 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate. The compound 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate hypothetically reacts with water and results in the release of a formic acid and 4-amino-4-deoxy-α-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate which in turn reacts with a KDO2-lipid A through a 4-amino-4-deoxy-L-arabinose transferase resulting in the release of a di-trans,octa-cis-undecaprenyl phosphate and a L-Ara4N-modified KDO2-Lipid A

PW123542

Pw123542 View Pathway
metabolic

Polymyxin Resistance

Pseudomonas aeruginosa
UDP-glucuronic acid compound undergoes a NAD dependent reaction through a bifunctional polymyxin resistance protein to produce UDP-Beta-L-threo-pentapyranos-4-ulose. This compound then reacts with L-glutamic acid through a UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase to produce an oxoglutaric acid and UDP-4-amino-4-deoxy-beta-L-arabinopyranose The latter compound interacts with a N10-formyl-tetrahydrofolate through a bifunctional polymyxin resistance protein ArnA, resulting in a tetrahydrofolate, a hydrogen ion and a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose, which in turn reacts with a product of the methylerythritol phosphate and polysoprenoid biosynthesis pathway, di-trans,octa-cis-undecaprenyl phosphate to produce a 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate. The compound 4-deoxy-4-formamido-alpha-L-arabinopyranosyl ditrans, octacis-undecaprenyl phosphate hypothetically reacts with water and results in the release of a formic acid and 4-amino-4-deoxy-α-L-arabinopyranosyl ditrans,octacis-undecaprenyl phosphate which in turn reacts with a KDO2-lipid A through a 4-amino-4-deoxy-L-arabinose transferase resulting in the release of a di-trans,octa-cis-undecaprenyl phosphate and a L-Ara4N-modified KDO2-Lipid A