PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128410 View Pathway	drug action Tapentadol Opioid Agonist Action Pathway Homo sapiens Tapentadol is a synthetic analgesic opioid with dual mechanism of action as a mu opioid agonist, and a norepinephrine reuptake inhibtor. It is an agonist of mu, kappa, and delta opioid receptors. It is also a weak serotonin reuptake inhibitor, but that doesn't contribute to the analgesic effect. Tapentadol binds to mu opioid receptors on the presynaptic membrane, stimulating the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as GABA is inhibited. Opioids close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability. Morphine acts at A delta and C pain fibres in the dorsal horn of the spinal cord. By decreasing neurotransmitter action there is less pain transmittance into the spinal cord. This leads to less pain perception. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: August 28, 2023 at 11:49 Last Updated: August 28, 2023 at 11:49
PW145654 View Pathway	drug action Tapinarof Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:18 Last Updated: October 07, 2023 at 16:18
PW124639 View Pathway	metabolic Targets for the reduction of acylcarnitine content Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Kristen Yee Created On: April 09, 2021 at 11:07 Last Updated: April 09, 2021 at 11:07
PW132502 View Pathway	metabolic Tasimelteon Drug Metabolism Homo sapiens Tasimelteon is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Tasimelteon passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:08 Last Updated: September 21, 2023 at 22:08
PW145952 View Pathway	drug action Tasimelteon Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:03 Last Updated: October 07, 2023 at 17:03
PW127587 View Pathway	drug action Tasosartan Action Pathway Homo sapiens Tasosartan is a selective angiotensin II (AngII) receptor type 1 (AT1) inhibitor. It is used for the treatment of hypertension and heart failure. This drug causes the blockade of the renin-angiotensin-aldosterone system (RAAS) at the level of the AT1 receptor. Tasosartan is an antagonist of the AT1 receptors localize in the vascular muscles and the adrenal gland. This drug thus causes dilatation, reduced secretion of avsopressin (ADH), and reduced production and secretion of aldosterone. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: May 11, 2023 at 11:30 Last Updated: May 11, 2023 at 11:30
PW123924 View Pathway	metabolic Taurine & Hypotaurine Metabolism Drosophila melanogaster Taurine and hypotaurine are aminosulfinic acids. Taurine has many physiological functions as neuromodulators, membrane stabilizers, facilitator of ion transport and aiding auditory transduction. Hypotaurine has roles such as antioxidant and a protective agent. Taurine and hypotaurine are synthesized from L-cysteine. L-Cysteine is involved in cyanoacid metabolism and glutathione metabolism. L-Cysteine goes through redox reactions, elimination reactions and other metabolism pathways to eventually form taurine and hypotaurine. L-Cysteine is converted to cysteamine, which can then form hypotaurine through the enzyme cysteamine dioxygenase. L-Cysteine can also be converted to 3-sulfinoalanine through the enzyme cysteine dioxygenase. Hypotaurine can then be formed from the enzymes glutamate decarboxylase and sulfinoalanine decarboxylase acting on 3-sulfinoalanine. 3-sulfinoalanine can form taurine by first converting to L-cysteate. L-Cysteate is then metabolized to taurine via glutamate decarboxylase and sulfinoalanine decarboxylase. The hypotaurine formed in this pathway can be metabolised to taurine, then taurine is metabolised to 5-L-glutamyl-taurine by reacting with (5-L-glutamyl)-peptide via the enzyme gamma-glutamyltranspeptidase. Taurine can also undergo excretion from the organism. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: June 09, 2020 at 15:01 Last Updated: June 09, 2020 at 15:01
PW002480 View Pathway	metabolic Taurine and Hypotaurine Biosynthesis Saccharomyces cerevisiae The biosynthesis of taurine and hypotaurine is processed by the same protein, glutamate decarboxylase. Hypotaurine is produced by 3-sulfino-L-alanine reacting with glutamate decarboxylase resulting in the release of carbon dioxide and hypotaurine. Taurine is produced by L-cysteate reacting with a glutamate decarboxylase resulting in the release of Taurine and carbon dioxide BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: February 22, 2016 at 14:36 Last Updated: February 22, 2016 at 14:36
PW122344 View Pathway	metabolic Taurine and Hypotaurine Metabolism Drosophila melanogaster BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: February 12, 2019 at 12:00 Last Updated: February 12, 2019 at 12:00
PW122490 View Pathway	metabolic Taurine and Hypotaurine Metabolism Xenopus laevis BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: May 01, 2019 at 10:59 Last Updated: May 01, 2019 at 10:59