PathWhiz

PathWhiz ID	Pathway	Meta Data
PW127608 View Pathway	drug action Tecovirimat Action Pathway Homo sapiens Tecovirimat (Tpoxx) is an antiviral used in the treatment of smallpox, monkeypox and cowpox. In fact, this drug is effective against all orthopoxviruses, including vaccinia, cowpox, ectromelia, rabbitpox, monkeypox and variola virus (smallpox). Tecovirimat was approved by the FDA in July 2018. Tecovirimal is an inhibitor of the P37 protein (VP37 envelope-wrapping protein)) of the orthopoxvirus. This protein is essential to form the wrapping complex of mature virions with late endosomal membranes by interacting with proteins such as Rab9 GTPase and TIP47.. The P37 protein is encoded by a highly conserved gene in all members of the orthopoxvirus genus. When Tecovirimat binds P37, this protein can not interact with the Rab9 GTPase and TIP47, which are components of late endosome-derived transport vesicles. In consequence, there is no formation of the wrapping complex for enveloped virions. This drug is available as an oral tablet and an intravenous formulation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: May 15, 2023 at 12:12 Last Updated: May 15, 2023 at 12:12
PW132509 View Pathway	metabolic Tecovirimat Drug Metabolism Homo sapiens Tecovirimat is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Tecovirimat passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:10 Last Updated: September 21, 2023 at 22:10
PW146488 View Pathway	drug action Tecovirimat Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:19 Last Updated: October 07, 2023 at 18:19
PW146853 View Pathway	drug action Tedizolid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:11 Last Updated: October 07, 2023 at 19:11
PW128371 View Pathway	drug action Tedizolid Phosphate Action Pathway Homo sapiens Tedizolid phosphate is an antibiotic, also known as Sivextro, used in the treatment of gram-positive bacterial infections. Tedizolid phosphate is a prodrug and is metabolized in the liver to its active form of Tedizolid. Tedizolid is part of the oxazolidinones class of antibacterials that are capable of inhibiting bacteria that are resistant to other antibiotics. The mechanism of action binds to the A site of the ribosome that interacts with the 23S rRNA subunit, which makes subsequent peptides nonfunctional protein. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 24, 2023 at 14:17 Last Updated: August 24, 2023 at 14:17
PW145934 View Pathway	drug action Tedizolid phosphate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:00 Last Updated: October 07, 2023 at 17:00
PW176143 View Pathway	metabolic Tedizolid Predicted Metabolism Pathway new Homo sapiens Metabolites of Tedizolid are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:17 Last Updated: November 29, 2023 at 14:17
PW146050 View Pathway	drug action Tegafur Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:17 Last Updated: October 07, 2023 at 17:17
PW146093 View Pathway	drug action Tegafur-uracil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:23 Last Updated: October 07, 2023 at 17:23
PW145170 View Pathway	drug action Tegaserod Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:14 Last Updated: October 07, 2023 at 15:14