PathWhiz

PathWhiz ID	Pathway	Meta Data
PW123981 View Pathway	metabolic Selenocompound Metabolism Arabidopsis thaliana The metabolism of selenium and its derived compounds begins with selenite, which enters plant cells through sulfate channels. Before it can enter the chloroplast to be further metabolised, with the help of thioredoxin reductase 2 it reacts with hydrogen ions to become hydrogen selenide, oxidizing NADPH in the process. Hydrogen selenide is then transported into the chloroplast, where it reacts with L-alanine and an oxidized electron acceptor to produce selenocysteine. This is then combined with O-succinyl-L-homoserine to produce selenocystathionine. Aided by cystathionine beta-lyase, selenocystathionine is then hydrolyzed and yields pyruvic acid and selenohomocysteine. After one more reaction involving 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase 2, selenomethionine is produced. This is a form in which selenium is commonly found in vascular plants and can be further metabolised for different uses. Diphosporic acid, S-methyl-methionine, and methylselenic acid are all produced from selenomethionine by different chemical reactions. Although selenium is not considered essential for many vascular plants, and may even be harmful at high concentrations, its presence has been shown to aid in a number of biological processes, such as photosynthesis and maintenance of general cell function. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Alyssah Created On: July 10, 2020 at 11:29 Last Updated: July 10, 2020 at 11:29
PW122495 View Pathway	metabolic Selenocompound Metabolism Danio rerio BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: May 01, 2019 at 11:01 Last Updated: May 01, 2019 at 11:01
PW122340 View Pathway	metabolic Selenocompound Metabolism Drosophila melanogaster BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: February 09, 2019 at 20:52 Last Updated: February 09, 2019 at 20:52
PW124156 View Pathway	metabolic Selenocompound metabolism Arabidopsis thaliana BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Dorsa Yahya Rayat Created On: September 12, 2020 at 17:40 Last Updated: September 12, 2020 at 17:40
PW002472 View Pathway	metabolic Selenocompound Metabolism Saccharomyces cerevisiae The the metabolism of selenocompounds starts with Selenocysteine being metabolized by a CGS resulting in the release of Seleno-cystathionine. The resulting compound is metabolized by a CBL resulting in the release of selenohomocysteine. The resulting compound reacts with MET resulting in the release of a seleno-methionine. Selenomethionine can be either metabolized into Seleno-methionyl-tRNA or a Methyl-selenol. Methyl-selenol can also be the result of Methyl-selenic acid reacting with a thioredoxin reductase or Se-methyl-selenocysteine reacting through a CTH. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: February 19, 2016 at 11:41 Last Updated: February 19, 2016 at 11:41
PW122494 View Pathway	metabolic Selenocompound Metabolism Xenopus laevis BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: May 01, 2019 at 11:01 Last Updated: May 01, 2019 at 11:01
PW075771 View Pathway	metabolic Selenocompound Metabolism Homo sapiens Selenate is the major inorganic selenocompound found in both animal and plant tissues. Selenocysteine is the predominant selenoamino acid in tissues when inorganic selenium is given to animals. Selenomethionine is the major selenocompound found initially in animals given this selenoamino acid, but is converted with time afterwards to selenocysteine. Selenomethionine is the major selenocompound in cereal grains, grassland legumes and soybeans. Selenomethionine can also be the major selenocompound in selenium enriched yeast, but the amount can vary markedly depending upon the growth conditions. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: xuan cao Created On: August 03, 2018 at 10:18 Last Updated: August 03, 2018 at 10:18
PW146261 View Pathway	drug action Selenomethionine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:48 Last Updated: October 07, 2023 at 17:48
PW146137 View Pathway	drug action Selenomethionine Se-75 Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:29 Last Updated: October 07, 2023 at 17:29
PW128107 View Pathway	drug action Selexipag Action Pathway Homo sapiens Selexipag is a non-prostanoid prostacyclin receptor agonist, also known as Uptravi typically used to treat pulmonary arterial hypertension. Selexipag is a selective prostacyclin receptor agonist, it is administered orally and is metabolized by carboylesterase1 into its active metabolite (ACT-333679). The metabolite has a high selectivity for prostacyclin receptor that activates it and subsequent G coupled protein, Gs, that increases cAMP levels. Increased cAMP levels leads to inhibited platelet aggregation and activation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: July 18, 2023 at 12:12 Last Updated: July 18, 2023 at 12:12