PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146072 View Pathway	drug action Rolapitant Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:20 Last Updated: October 07, 2023 at 17:20
PW101965 View Pathway	disease Role of Tob in T-cell activation Homo sapiens Tob, a member of an anti-proliferative gene family, is highly expressed in anergic T cell clones. Tob is also expressed in unstimulated peripheral blood T lymphocytes and down-regulated during activation. Forced expression of Tob inhibits T cell proliferation and transcription of cytokines and cyclins. In contrast, suppression of Tob with an antisense oligonucleotide augments CD3-mediated responses and abrogates the requirement of costimulation for maximal proliferation and cytokine secretion. Tob associated with Smad2 and Smad4 and enhances Smad DNA-binding. The inhibitory effect of Tob on interleukin 2 (IL-2) transcription is not mediated by blockade of NFAT, AP-1 or NF-kappaB transactivation but by enhancement of Smad binding on the -105 negative regulatory element of the IL-2 promoter. Thus, T cell quiescence is an actively maintained phenotype that must be suppressed for T cell activation to occur. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Aidin Foroutannaddafi Created On: August 29, 2018 at 12:00 Last Updated: August 29, 2018 at 12:00
PW000703 View Pathway	drug action Rolitetracycline Action Pathway Homo sapiens Rolitetracycline is a broad spectrum second antibiotic formed by the N-aminomethylation of the carboxamide function of tetracycline. Classified as a second generation tetracycline due to it’s semi-synthesis, rolitetracycline like tetracycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. This prevents tRNA from interacting with the ribosome ultimately halting the addition of amino acids to peptide chains used in protein synthesis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: June 23, 2014 at 03:38 Last Updated: June 23, 2014 at 03:38
PW128360 View Pathway	drug action Rolitetracycline Action Pathway (new) Homo sapiens Rolitetracycline, a broad-spectrum tetracycline antibiotic, is used for treatment when higher concentrations are required. Rolitetracycline passively diffuses through porin channels into bacterial cells and binds to the 30S ribosomal subunit. By binding to 30S subunit which prevents tRNA binding to mRNA ribosome complex and disrupting protein synthesis. Milk and dairy products should be avoided in order to optimize the absorption of rolitetracycline. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 24, 2023 at 09:49 Last Updated: August 24, 2023 at 09:49
PW145367 View Pathway	drug action Rolitetracycline Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:40 Last Updated: October 07, 2023 at 15:40
PW145669 View Pathway	drug action Romidepsin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:20 Last Updated: October 07, 2023 at 16:20
PW144397 View Pathway	drug action Ropinirole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:33 Last Updated: October 07, 2023 at 13:33
PW128056 View Pathway	drug action Ropinirole Mechanism of Action Action Pathway Homo sapiens Ropinirole is a nonergoline dopamine agonist. used in the management in early and late Parkinson's disease. Ropinirole has a high affinity for and stimulates the post-synaptic dopamine receptors D2 in the central and peripheral nervous systems. The dopamine receptors (D2) are g-protein-coupled inhibitory neurons predominantly in the striatonigral, mesolimbic, and tuberoinfundibular systems. They inhibit adenylyl cyclase and calcium (Ca2+) channels and activate potassium channels leading to their physiological functions. The exact mechanism of action of ropinirole as a treatment for Parkinson’s disease is unknown, however, it is believed to be related to its ability to selectively stimulate dopamine D2 receptors within the caudate-putamen system in the brain. This system affects body movement. Negligible affinity is seen for ropinirole at α2 adrenoreceptors in the periphery and 5HT-1 receptor. Ropinirole has no affinity at the D1-like receptors, benzodiazepine or GABA receptors BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 12, 2023 at 09:17 Last Updated: July 12, 2023 at 09:17
PW126560 View Pathway	drug action Ropivacaine Homo sapiens Ropivacaine an aminoamide analgesic is a racemic mixture of "S" and "R" enantiomers used for local anesthesia or for short term management of pain. Ropivacaine acts to block generation and propagation of action potentials by increasing the threshold for electrical excitation. This is done by blocking the sodium channel which causes a inhibits depolarization and decreases action potentials. Ropivacaine is metabolized in the liver by cytochrome P4501A through aromatic hydroxylation. The resulting metabolite 3-hydroxy ropivacaine is excreted by diruesis. Precaution should be taken with high systemic doses of ropivacaine which can effect the central nervous system and cardiovascular system. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: January 10, 2022 at 18:27 Last Updated: January 10, 2022 at 18:27
PW000410 View Pathway	drug action Ropivacaine Action Pathway Homo sapiens Ropivacaine exerts its local anaesthetic effect by blocking voltage-gated sodium channels in peripheral neurons. Ropivacaine diffuses across the neuronal plasma membrane in its uncharged base form. Once inside the cytoplasm, it is protonated and this protonated form enters and blocks the pore of the voltage-gated sodium channel from the cytoplasmic side. For this to happen, the sodium channel must first become active so that so that gating mechanism is in the open state. Therefore ropivacaine preferentially inhibits neurons that are actively firing. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45