PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128160 View Pathway	drug action Thioridazine Serotonin Antagonist Action Pathway Homo sapiens Thioridazine is a trifluoro-methyl phenothiazine derivative. Thioridazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; blocks alpha-adrenergic effect, depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. Similar to other first-generation or typical antipsychotics, thioridazine is a medication used to treat schizophrenia. Other indications for use include other psychotic disorders, depressive disorders, pediatric behavioral disorders, and geriatric psychoneurotic manifestations. Positive symptoms are believed to manifest as a result of increased levels of dopamine in the mesolimbic pathway. More specifically, thioridazine blocks DA-2 receptors in the mesolimbic pathway, diminishing positive symptoms. Thioridazine is classified as a low potency first-generation antipsychotic, and as such, is relatively sedating. Thioridazine is a substrate of the hepatic enzyme CYP450 2D6 and is also an inhibitor of the same enzyme. The drug also exhibits activity at muscarinic receptors (most notably the M1 receptor), which is most likely the source of its anticholinergic effects (e.g., dry mouth, constipation, etc.), the alpha 1A adrenergic receptor (which may explain its association with orthostatic hypotension), the H1 histamine receptor (probably accounting for much of its sedating effect), and the hERG gene, which is likely responsible for its cardiotoxicity BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 26, 2023 at 14:19 Last Updated: July 26, 2023 at 14:19
PW123546 View Pathway	metabolic Thiosulfate Disproportionation III Pseudomonas aeruginosa Thiosulfate sulfurtransferase (also known as rhodanese) can facilitate the transfer of a sulfur atom from sulfur donors to nucleophilic sulfur acceptors, and it has been found in many major phyla (prokaryotic and eukaryotic). The role of thiosulfate sulfurtransferase might be the detoxification of cyanide in both bacteria and mammals, or it might also involve in formation of prosthetic groups in iron-sulfur proteins. In this pathway, thiosulfate and hydrogen cyanide have been catalyzed by thiosulfate sulfurtransferase to form thiocyanate and sulfite. Sulfite is used in later sulfur metabolism. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 22:30 Last Updated: August 12, 2019 at 22:30
PW002060 View Pathway	metabolic Thiosulfate Disproportionation III Escherichia coli Thiosulfate sulfurtransferase (also known as rhodanese) can facilitate the transfer of a sulfur atom from sulfur donors to nucleophilic sulfur acceptors, and it has been found in many major phyla (prokaryotic and eukaryotic). The role of thiosulfate sulfurtransferase might be the detoxification of cyanide in both bacteria and mammals, or it might also involve in formation of prosthetic groups in iron-sulfur proteins. In this pathway, thiosulfate and hydrogen cyanide have been catalyzed by thiosulfate sulfurtransferase to form thiocyanate and sulfite. Sulfite is used in later sulfur metabolism. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: October 09, 2015 at 09:50 Last Updated: October 09, 2015 at 09:50
PW146175 View Pathway	drug action Thiosulfuric acid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:35 Last Updated: October 07, 2023 at 17:35
PW132352 View Pathway	metabolic Thiotepa Drug Metabolism Homo sapiens Thiotepa is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Thiotepa passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:07 Last Updated: September 21, 2023 at 21:07
PW145563 View Pathway	drug action Thiotepa Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:05 Last Updated: October 07, 2023 at 16:05
PW128181 View Pathway	drug action Thiothixene Dopamine Antagonist Action Pathway Homo sapiens Thiothixene is an antipsychotic of the thioxanthene series. Thiothixene acts as an antagonist (blocking agent) on different post-sysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects) BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 28, 2023 at 12:17 Last Updated: July 28, 2023 at 12:17
PW145486 View Pathway	drug action Thiothixene Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:55 Last Updated: October 07, 2023 at 15:55
PW132294 View Pathway	metabolic Thiram Drug Metabolism Homo sapiens Thiram is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Thiram passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:41 Last Updated: September 21, 2023 at 20:41
PW146617 View Pathway	drug action Thiram Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:38 Last Updated: October 07, 2023 at 18:38