PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145241 View Pathway	drug action Sertaconazole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:23 Last Updated: October 07, 2023 at 15:23
PW176403 View Pathway	metabolic Sertaconazole Predicted Metabolism Pathway Homo sapiens Metabolites of Sertaconazole are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 16:52 Last Updated: December 07, 2023 at 16:52
PW145657 View Pathway	drug action Sertindole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:19 Last Updated: October 07, 2023 at 16:19
PW176355 View Pathway	metabolic Sertindole Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:29 Last Updated: December 07, 2023 at 15:29
PW126521 View Pathway	drug action Sertraline Action Pathway (New) Homo sapiens Sertraline is a selective serotonin reuptake inhibitor (SSRI) indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD). Common off-label uses for sertraline include the prevention of post stroke depression, generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope. It's mechanism of action it to bind selectively bind to the sodium dependent serotonin transporter and blocking the recycling of serotonin from the synapse. As serotonin accumulates it enhances the serotonergic function of the 5-hydroxytryptamine 1A receptor leading to decreased anxiety and depressive moods. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: December 23, 2021 at 14:36 Last Updated: December 23, 2021 at 14:36
PW145193 View Pathway	drug action Sertraline Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:16 Last Updated: October 07, 2023 at 15:16
PW127973 View Pathway	drug action Sertraline Mechanism of Action Action Pathway (New) Homo sapiens Sertraline is a selective serotonin reuptake inhibitor (SSRI) indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD). Common off-label uses for sertraline include the prevention of post stroke depression, generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neuro cardiogenic syncope. Sertraline also has minimal effects on norepinephrine and dopamine uptake, and research has shown that it has more dopaminergic activity than other medications in the same SSRI class. Sertraline binds selectively bind to the sodium dependent serotonin transporter and blocks the recycling of serotonin from the synapse. As serotonin accumulates it enhances the serotonergic function of the 5-hydroxytryptamine 1A receptor leading to decreased anxiety and depressive moods. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: June 26, 2023 at 11:05 Last Updated: June 26, 2023 at 11:05
PW128111 View Pathway	drug action Sertraline Mechanism of Action Action Pathway New Homo sapiens Sertraline is a selective serotonin reuptake inhibitor (SSRI) indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD). Common off-label uses for sertraline include the prevention of post stroke depression, generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neuro cardiogenic syncope. Sertraline also has minimal effects on norepinephrine and dopamine uptake, and research has shown that it has more dopaminergic activity than other medications in the same SSRI class. Sertraline binds selectively bind to the sodium dependent serotonin transporter and blocks the recycling of serotonin from the synapse. As serotonin accumulates it enhances the serotonergic function of the 5-hydroxytryptamine 1A receptor leading to decreased anxiety and depressive moods. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 18, 2023 at 15:07 Last Updated: July 18, 2023 at 15:07
PW176135 View Pathway	metabolic Sertraline Predicted Metabolism Pathway new Homo sapiens Metabolites of Sertraline are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:13 Last Updated: November 29, 2023 at 14:13
PW122499 View Pathway	metabolic Sesquiterpenoid Biosynthesis Arabidopsis thaliana Sesquiterpenoids have 15 carbons and three isoprene units. They are derived from farnesyl diphosphate. They may contain rings or be acyclic, depending on the bonds formed by the loss of the diphosphate group. First, the terpenoid backbone is synthesized, producing farnesyl pyrophosphate. Two molecules of farnesyl pyrophosphate then join together to form presqualene diphosphate, catalyzed by squalene synthase 1. Then, the same enzyme removes the pyrophosphate group and replaces it with a hydrogen ion, forming squalene. Squalene then undergoes oxidation of one of its bonds via squlene monooxygenase 1, to form (S)-2,3-epoxysqualene. This may then proceed to the steroid biosynthesis pathway or may react with an isomerase or lyase to form a chair-chair-chair-boat triterpenoid. Similarly, squalene may interact with an isomerase or lyase to form a chair-chair-chair-chair triterpenoid. After the backbone is complete, farnesyl pyrophosphate can have its pyrophosphate removed by different enzymes, leading to different conformations of sesquiterpenoids. If it interacts with (Z)-gamma-bisabolene synthase, it forms gamma-bisabolene. If it interacts wtih (+)-alpha-barbatene synthase, it forms (+)-alpha-barbatene, if it interacts wtih beta-chamigrene synthase it forms (+)-beta-chamigrene, and finally if it interacts with thujopsene synthase it forms (+)-thujopsene. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: May 08, 2019 at 10:21 Last Updated: May 08, 2019 at 10:21