PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128232 View Pathway	drug action Temozolomide Action Pathway Homo sapiens Temozolomide (TMZ) is an antineoplastic from the alkylating agent drug class. This molecule is an imidazotetrazine prodrug that is stable at acidic pH but undergoes spontaneous nonenzymatic hydrolysis at neutral or slightly basic pH; allowing its administration to be oral and intravenous too. Temozolomide is indicated in the treatment of newly diagnosed glioblastoma and refractory anaplastic astrocytoma. This molecule is a very small lipophilic, it can then easily get through the blood-brain barrier. The mechanism of action of this drug needs many reactions beforehand: TMZ undergoes spontaneous nonenzymatic breakdown at physiological pH to form 5-(3-methyltriazen-1-yl) imidazole-4-carboxamide (MTIC), which then reacts with water to produce 5-aminoimidazole-4-carboxamide (AIC) and a highly reactive methyl diazonium cation. TMZ is a bit specific to tumor cells because glioblastoma typically possesses a more alkaline pH than healthy tissue, favoring its activation in tumor cells. The methyl diazonium cation formed methylates DNA at the N7 and O6 position of guanine, and the N3 position of adenine. The cellular repair system will eventually lead to DNA strand breaks that will end in the apoptosis of the cell. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 04, 2023 at 13:55 Last Updated: August 04, 2023 at 13:55
PW144958 View Pathway	drug action Temozolomide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:48 Last Updated: October 07, 2023 at 14:48
PW128248 View Pathway	metabolic Template for Biotech Drug Metabolism Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 09, 2023 at 15:44 Last Updated: August 09, 2023 at 15:44
PW128172 View Pathway	metabolic Template for Biotech Drug Metabolism Reticuloendothelial System Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: July 27, 2023 at 13:01 Last Updated: July 27, 2023 at 13:01
PW175941 View Pathway	metabolic Template Predicted Metabolism Pathway Homo sapiens Template PIS1M1, Template PIS1M2, Template PIS1M3,Template PIS1M4, Template PIS2M1, Template PIS2M2, Template PIS2M3 are metabolites of Template predicted with biotransformer. Template M1, Template M2, Template M3, Template M4, Template M5, Template M6, Template M7, Template M8, Template M9, Template M10, Template M11, Template M12, Template M13, Template M14, Template M15, Template M16, Template M17, Template M18 are metabolites of Template predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 16, 2023 at 14:31 Last Updated: November 16, 2023 at 14:31
PW176182 View Pathway	metabolic Template2M Predicted Metabolism Pathway Homo sapiens Metabolites of Template2M are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 10:31 Last Updated: December 04, 2023 at 10:31
PW176221 View Pathway	metabolic Template2MD Predicted Metabolism Pathway Homo sapiens Metabolites of Template2MD are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 12:52 Last Updated: December 04, 2023 at 12:52
PW176360 View Pathway	metabolic Template3MB1 Predicted Metabolism Pathway Homo sapiens Metabolites of Template3MB1 are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:41 Last Updated: December 07, 2023 at 15:41
PW176314 View Pathway	metabolic Template3MB2 Predicted Metabolism Pathway Homo sapiens Metabolites of Template3MB2 are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 14:14 Last Updated: December 07, 2023 at 14:14
PW176419 View Pathway	metabolic Template3MB4 Predicted Metabolism Pathway Homo sapiens Metabolites of Template3MB4 are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 08, 2023 at 09:37 Last Updated: December 08, 2023 at 09:37