PathWhiz

PathWhiz ID	Pathway	Meta Data
PW144820 View Pathway	drug action Sufentanil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:29 Last Updated: October 07, 2023 at 14:29
PW126550 View Pathway	drug action Sufentanil Opioid Agonist Action Pathway Homo sapiens Sufentanil is an opioid used to induce and maintain anesthesia, to act as an analgesic in labor and delivery, and to treat severe, acute pain. It is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Sufentanil binds to mu opioid receptors, stimulating the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as GABA is inhibited. Opioids close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability. Sufentanil acts at A delta and C pain fibres in the dorsal horn of the spinal cord. By decreasing neurotransmitter action there is less pain transmittance into the spinal cord. This leads to less pain perception. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: January 10, 2022 at 00:55 Last Updated: January 10, 2022 at 00:55
PW145676 View Pathway	drug action Sugammadex Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:22 Last Updated: October 07, 2023 at 16:22
PW146090 View Pathway	drug action Sulbactam Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:23 Last Updated: October 07, 2023 at 17:23
PW127400 View Pathway	drug action Sulconazole Action Pathway Homo sapiens Sulconazole is a topical antifungal agent used for the treatment of tinea cruris, tinea corporis, and tinea versicolor caused by susceptible fungal strains. It is known by the brand name Exelderm available as a topical cream and solution. Sulconazole nitrate, the active ingredient, is an imidazole derivative that inhibits the growth of common pathogenic dermatophytes making it an effective treatment for tinea cruris and tinea corporis infections. The exact mechanism of action of sulconazole is unknown, however, it is assumed like other imidazoles that is blocks the enzyme lanosterol 14-alpha demethylase which inhibits the synthesis of 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol . Lanosterol 14-alpha demethylase is the enzyme that catalyzes the synthesis of 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol from lanosterol. With this enzyme inhibited ergosterol synthesis cannot occur which causes a significant low concentration of ergosterol in the fungal cell. Ergosterol is essential in maintaining membrane integrity in fungi. Without ergosterol, the fungus cell cannot synthesize membranes thereby increasing fluidity and preventing growth of new cells. This leads to cell lysis which causes it to collapse and die. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: January 05, 2023 at 14:50 Last Updated: January 05, 2023 at 14:50
PW132467 View Pathway	metabolic Sulconazole Drug Metabolism Homo sapiens Sulconazole is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Sulconazole passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:55 Last Updated: September 21, 2023 at 21:55
PW145820 View Pathway	drug action Sulconazole Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:44 Last Updated: October 07, 2023 at 16:44
PW132603 View Pathway	metabolic Sulfabenzamide Drug Metabolism Homo sapiens Sulfabenzamide is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Sulfabenzamide passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:35 Last Updated: September 21, 2023 at 22:35
PW146111 View Pathway	drug action Sulfabenzamide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:26 Last Updated: October 07, 2023 at 17:26
PW128400 View Pathway	drug action Sulfacetamide Action Pathway Escherichia coli (strain K12) Sulfacetamide is an anti-infective agent from the sulfonamide drug class (antibiotic). This drug can be used topically to treat skin infections (acne vulgaris), as well as orally to treat urinary tract infections. It is also indicated in the treatment of bacterial vaginitis, keratitis, acute conjunctivitis, and blepharitis. Sulfacetamide is a bacteriostatic drug, it stops the replication of the bacteria. This molecule binds to the dihydropteroate synthase protein in a wide-spectrum activity against most gram-positive and many gram-negative organisms. The inhibited enzyme is essential for the synthesis of folic acid from para-aminobenzoic acid (PABA) molecules. Folic acids are essential for the growth of the bacteria. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 28, 2023 at 10:06 Last Updated: August 28, 2023 at 10:06