PathWhiz

PathWhiz ID	Pathway	Meta Data
PW000362 View Pathway	drug action Tetracycline Action Pathway Homo sapiens Tetracycline is a short-acting antibiotic that is semi-synthetically produced from chlortetracycline, a compound derived from Streptomyces aureofaciens. Tetracycline enters bacterial cells by passively diffusing through membrane porin channels. Once inside the cell, tetracycline reversibly binds to the 30S subunit just above the binding site for aminoacyl tRNA. At its primary binding site, interactions with the sugar phosphate backbone of residues in helices 31 and 34 via hydrogen bonds with oxygen atoms and hydroxyl groups on the hydrophilic side of the tetracycline help anchor the drug in position. Salt bridge interactions between the backbone of 16S rRNA and tetracycline are mediated by a magnesium ion in the binding site. Tetracycline prevents incoming aminoacyl tRNA from binding to the A site on the ribosome-RNA complex via steric hindrance. This causes inhibition of protein synthesis and hence bacterial cell growth. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW128349 View Pathway	drug action Tetracycline Action Pathway Homo sapiens Tetracycline is a broad-use antibiotic that is produced by Streptomyces and used to treat bacterial infections such as rocky mountain spotted fever, typhus fever and tick fevers. it is most effectively administered orally but can also be administered via intramuscular injection. It has a half-life of 6-12 hours and is concentrated by the liver and excreted through the urine and feces. Tetracycline can passively transport itself through the bacterial membrane and goes on to inhibit bacterial growth. It stops bacterial growth by binding to the 30S subunits that inhibit the transfer of amino-acyl tRNA to site A of the ribosome. Thus halting protein synthesis and stopping bacterial growth. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 23, 2023 at 11:01 Last Updated: August 23, 2023 at 11:01
PW123929 View Pathway	metabolic Tetracycline Biosynthesis Kitasatospora aureofaciens Tetracyclines are aromatic polyketide antibiotics produced via type II polyketide synthases and possess several antibiotic drug properties that work against the activity of Gram-positive and negative bacterial pathogens and are also used to treat several types of bacterial infections in the body. They are natural polyketides produced by actinomycete bacteria like Kitasatospora aureofaciens and are unique by their tetracyclic ring structure and a richly substituted A ring. This pathway shows biosynthesis of naturally occurring tetracyclines (oxytetracycline, tetracycline and chlortetracycline) via the common intermediate anhydrotetracycline. Four genes: oxyE, oxyL, oxyQ, oxyT encode the enzymes that are involved in the modifications that generate anhydrotetracycline. The final two enzymes in the pathway are monooxygenases that are encoded by the gene oxyS and an F420-dependent dehydrogenase encoded by oxyR. OxyS catalyzes two successive monooxygenation reactions where one variation leads to the formation of tetracycline and the other leads to the formation of oxytetracycline. Tetracycline also leads to the formation of chlortetracycline via the enzyme flavin reductase (NADH). BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Aadhavya Sivakumaran Created On: June 10, 2020 at 13:34 Last Updated: June 10, 2020 at 13:34
PW144870 View Pathway	drug action Tetracycline Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:36 Last Updated: October 07, 2023 at 14:36
PW146195 View Pathway	drug action Tetracycline phosphate complex Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:38 Last Updated: October 07, 2023 at 17:38
PW176235 View Pathway	metabolic Tetracycline Predicted Metabolism Pathway Homo sapiens Metabolites of Tetracycline are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 13:03 Last Updated: December 04, 2023 at 13:03
PW146352 View Pathway	drug action Tetradecyl hydrogen sulfate (ester) Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:00 Last Updated: October 07, 2023 at 18:00
PW176538 View Pathway	metabolic Tetradecyl hydrogen sulfate (ester) Predicted Metabolism Pathway Homo sapiens Metabolites of Tetradecyl hydrogen sulfate (ester) are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 13, 2023 at 14:50 Last Updated: December 13, 2023 at 14:50
PW146835 View Pathway	drug action Tetraferric tricitrate decahydrate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:09 Last Updated: October 07, 2023 at 19:09
PW146991 View Pathway	metabolic Tetrahydrocannabinol Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:36 Last Updated: October 10, 2023 at 13:36