PathWhiz

PathWhiz ID	Pathway	Meta Data
PW123559 View Pathway	metabolic Pyruvate to Cytochrome bd Terminal Oxidase Electron Transfer Pseudomonas aeruginosa The reaction of pyruvate to cytochrome bd terminal oxidase electron transfer starts with 2 pyruvate and 2 water molecules reacting in a pyruvate oxidase resulting in the release of 4 electrons into the inner membrane, and releasing 2 carbon dioxide molecules , 2 acetate and 4 hydrogen ion into the cytosol. 2 ubiquinone,4 hydrogen ion and 4 electron ion react resulting in the release of 2 ubiquinol . The 2 ubiquinol in turn release 4 hydrogen ions into the periplasmic space through a cytochrome bd-I terminal oxidase and releasing 4 electrons through the enzyme. Oxygen and 4 hydrogen ion reacts with the 4 electrons resulting in 2 water molecules. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 22:31 Last Updated: August 12, 2019 at 22:31
PW144265 View Pathway	drug action Pyruvic acid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:03 Last Updated: October 07, 2023 at 13:03
PW132535 View Pathway	metabolic Pyrvinium Drug Metabolism Homo sapiens Pyrvinium is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Pyrvinium passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:17 Last Updated: September 21, 2023 at 22:17
PW145817 View Pathway	drug action Pyrvinium Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:44 Last Updated: October 07, 2023 at 16:44
PW132266 View Pathway	metabolic Quaternium-15 Drug Metabolism Homo sapiens Quaternium-15 is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Quaternium-15 passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:29 Last Updated: September 21, 2023 at 20:29
PW146794 View Pathway	drug action Quaternium-15 Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:03 Last Updated: October 07, 2023 at 19:03
PW127720 View Pathway	drug action Quazepam Action Pathway Homo sapiens Quazepam is a long-acting benzodiazepine used to manage insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABAA receptors and low affinity for other receptors. It can be found under the brand name Doral. Quazepam is indicated for the treatment of insomnia characterized by difficulty falling asleep, frequent nocturnal awakenings, and/or early morning awakenings. Like other benzodiazepines, quazepam likely exerts its effects by potentiating the effect of gamma-aminobutyric acid (GABA) on GABA(A) receptors, the main inhibitory neurotransmitter receptors in the mammalian brain. GABA(A) receptors are a component of GABA-gated ionotropic chloride channels that produce inhibitory postsynaptic potentials - following activation by GABA, the channel undergoes a conformational change that allows the passage of chloride ions through the channel. The inhibitory potentials produced by GABA neurotransmission play an integral role in the suppression and control of epileptiform nerve firing such as that seen in epilepsy, which makes the GABA system a desirable target in the treatment of epilepsy. Benzodiazepines are positive allosteric modulators of GABA(A) function. They bind to the interface between alpha (α) and gamma (γ) subunits on the receptor, commonly referred to as the benzodiazepine binding site, and modulate the receptor such that its inhibitory response to GABA binding is dramatically increased. Quazepam is administered as an oral tablet. Possible side effects of using quazepam may include drowsiness, lowered alertness, confusion, and loss of coordination. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: May 25, 2023 at 11:41 Last Updated: May 25, 2023 at 11:41
PW145458 View Pathway	drug action Quazepam Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:52 Last Updated: October 07, 2023 at 15:52
PW128432 View Pathway	drug action Quetiapine Dopamine Antagonist Action Pathway Homo sapiens Quetiapine is used in the symptomatic treatment of schizophrenia. In addition, it may be used for the management of acute manic or mixed episodes in patients with bipolar I disorder, as a monotherapy or combined with other drugs. It may be used to manage depressive episodes in bipolar disorder. In addition to the above indications, quetiapine is used in combination with antidepressant drugs for the treatment of major depression. Although the mechanism of action of quetiapine is not fully understood, several proposed mechanisms exist. In schizophrenia, its actions could occur from the antagonism of dopamine type 2 (D2) and serotonin 2A (5HT2A) receptors. In bipolar depression and major depression, quetiapine's actions may be attributed to the binding of this drug or its metabolite to the norepinephrine transporter. Additional effects of quetiapine, including somnolence, orthostatic hypotension, and anticholinergic effects, may result from the antagonism of H1 receptors, adrenergic α1 receptors, and muscarinic M1 receptors, respectively. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 28, 2023 at 14:46 Last Updated: August 28, 2023 at 14:46
PW145310 View Pathway	drug action Quetiapine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:31 Last Updated: October 07, 2023 at 15:31