PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176248 View Pathway	metabolic Chlorpropamide Predicted Metabolism Pathway Homo sapiens Metabolites of Chlorpropamide are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:04 Last Updated: December 04, 2023 at 14:04
PW128178 View Pathway	drug action Chlorprothixene Dopamine Antagonist Action Pathway Homo sapiens Chlorprothixene is a thioxanthene antipsychotic. Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 28, 2023 at 10:18 Last Updated: July 28, 2023 at 10:18
PW145325 View Pathway	drug action Chlorprothixene Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:34 Last Updated: October 07, 2023 at 15:34
PW176648 View Pathway	drug action Chlorprothixene H1 Antihistamine Smooth Muscle Relaxation Action Pathway Homo sapiens Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. H1-antihistamines act on H1 receptors in T-cells to inhibit the immune response, in blood vessels to constrict dilated blood vessels, and in smooth muscles of lungs and intestines to relax those muscles. Allergies causes blood vessel dilation which causes swelling (edema) and fluid leakage. Chlorprothixene also inhibits the H1 histamine receptor on bronchiole smooth muscle myocytes. This normally activates the Gq signalling cascade which activates phospholipase C which catalyzes the production of Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG). Because of the inhibition, IP3 doesn't activate the release of calcium from the sarcoplasmic reticulum, and DAG doesn't activate the release of calcium into the cytosol of the endothelial cell. This causes a low concentration of calcium in the cytosol, and it, therefore, cannot bind to calmodulin. Calcium bound calmodulin is required for the activation of myosin light chain kinase. This prevents the phosphorylation of myosin light chain 3, causing an accumulation of myosin light chain 3. This causes muscle relaxation, opening up the bronchioles in the lungs, making breathing easier. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: December 19, 2023 at 13:06 Last Updated: December 19, 2023 at 13:06
PW176741 View Pathway	drug action Chlorprothixene H1-Antihistamine Blood Vessel Constriction Action Pathway Homo sapiens Chlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene inhibits the H1 histamine receptor on blood vessel endothelial cells. This normally activates the Gq signalling cascade which activates phospholipase C which catalyzes the production of Inositol 1,4,5-trisphosphate (IP3) and Diacylglycerol (DAG). Because of the inhibition, IP3 doesn't activate the release of calcium from the sarcoplasmic reticulum, and DAG doesn't activate the release of calcium into the cytosol of the endothelial cell. This causes a low concentration of calcium in the cytosol, and it, therefore, cannot bind to calmodulin. Calcium bound calmodulin is required for the activation of the calmodulin-binding domain of nitric oxide synthase. The inhibition of nitric oxide synthesis prevents the activation of myosin light chain phosphatase. This causes an accumulation of myosin light chain-phosphate which causes the muscle to contract and the blood vessel to constrict, decreasing the swelling and fluid leakage from the blood vessels caused by allergens. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: December 19, 2023 at 14:10 Last Updated: December 19, 2023 at 14:10
PW176496 View Pathway	metabolic Chlorprothixene Predicted Metabolism Pathway Homo sapiens Metabolites of Chlorprothixene are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 13, 2023 at 12:47 Last Updated: December 13, 2023 at 12:47
PW128189 View Pathway	drug action Chlorprothixene Serotonin Antagonist Action Pathway Homo sapiens Chlorprothixene is a thioxanthene antipsychotic. Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 31, 2023 at 09:05 Last Updated: July 31, 2023 at 09:05
PW146644 View Pathway	drug action Chlorquinaldol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:42 Last Updated: October 07, 2023 at 18:42
PW128373 View Pathway	drug action Chlortetracycline Action Pathway Homo sapiens Chlortetracycline is a tetracycline antibiotic commonly used for veterinary practice, that is commonly administered via topical ointment. Chlortetracycline acts by competing for the A site of the bacterial ribosome, by doing so the tRNA cannot bind to the site and thus no more amino acids cannot be added to the peptide chain. Ultimately leading to protein synthesis and halting growth and reproduction, as proteins cannot be synthesized that are necessary for bacteria cell reproduction. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 24, 2023 at 19:57 Last Updated: August 24, 2023 at 19:57
PW145973 View Pathway	drug action Chlortetracycline Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:06 Last Updated: October 07, 2023 at 17:06