PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146622 View Pathway	drug action Proxibarbal Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:39 Last Updated: October 07, 2023 at 18:39
PW000909 View Pathway	metabolic PRPP Biosynthesis Escherichia coli The biosynthesis of phosphoribosyl pyrophosphate begins as a product of the pentose phosphate and D-ribose 5-phosphate interaction. When catalyzed with a phosphopentomutase, the product is a ribose 1-phosphate. Ribose 1-phosphate can interact spontaneously with ATP resulting in a release of hydrogen ion, ADP and a ribose 1,5-biphosphate. Ribose 1,5-biphosphate is then phosphorylated through a ribose 1,5-bisphosphokinase resulting in the release of ADP and phosphoribosyl pyrophosphate. Phosphoribosyl pyrophosphate will then participate in the purine nucleotides de novo biosynthesis pathway. Alternatively pentose phosphate and D-ribose 5-phosphate's interaction can be phosphorylated through an ATP driven ribose-phosphate diphosphokinase resulting in a release of a hydrogen ion, an AMP and a phosphoribosyl pyrophosphate which will again participate in the purine nucleotides de novo biosynthesis pathway. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: May 29, 2015 at 13:29 Last Updated: May 29, 2015 at 13:29
PW122417 View Pathway	metabolic PRPP Biosynthesis Saccharomyces cerevisiae The biosynthesis of phosphoribosyl pyrophosphate begins with a product of the pentose phosphate, D-ribose 5-phosphate interact with a phosphopentomutase resulting in a Ribose 1-phosphate or it can be phosphorylated through an ATP driven ribose-phosphate diphosphokinase resulting in a release of a hydrogen ion, an AMP and a phosphoribosyl pyrophosphate. The latter compound is then involved in the purine nucleotides de novo biosynthesis pathway. Ribose 1-phosphate can interact spontaneously with ATP resulting in a release of hydrogen ion, ADP and a ribose 1,5-biphosphate. The latter compound is then phosphorylated through a ribose 1,5-bisphosphokinase resulting in the release of ADP and phosphoribosyl pyrophosphate. The latter compound is then involved in the purine nucleotides de novo biosynthesis pathway. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Debra Lipton Created On: March 27, 2019 at 15:16 Last Updated: March 27, 2019 at 15:16
PW128663 View Pathway	drug action Prucalopride Action Pathway Homo sapiens Prucalopride acts as a selective stimulator of the 5-HT4 receptors while having no interaction with hERG channel or 5-HT1 receptors which reduces significantly the cardiovascular risk found in other similar drugs. 5-HT4 receptors can be found throughout the gastrointestinal tract primarily in smooth muscle cells, enterochromaffin cells, and myenteric plexus. Its activation produces the release of acetylcholine which is the major excitatory neurotransmitter in the GI tract. Hence, prucalopride stimulates motility by interacting specifically with 5-HT4 receptors in the GI tract which causes a release of acetylcholine and further contraction of the muscle layer of the colon and relaxation of the circular muscle layer leading to the propulsion of luminal content. Prucalopride is indicated for the treatment of chronic idiopathic constipation (CIC) in adults. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: September 08, 2023 at 15:12 Last Updated: September 08, 2023 at 15:12
PW145717 View Pathway	drug action Prucalopride Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:27 Last Updated: October 07, 2023 at 16:27
PW124237 View Pathway	metabolic Prueba Homo sapiens Prueba de la prueba de la prueba BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: October 17, 2020 at 19:57 Last Updated: October 17, 2020 at 19:57
PW124244 View Pathway	metabolic Prueba 2 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 18, 2020 at 21:10 Last Updated: October 18, 2020 at 21:10
PW124320 View Pathway	metabolic prueba 50000 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: November 06, 2020 at 21:38 Last Updated: November 06, 2020 at 21:38
PW124161 View Pathway	disease prueba1111 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: September 15, 2020 at 04:22 Last Updated: September 15, 2020 at 04:22
PW125983 View Pathway	metabolic Prunasin and Amygdalin Biosynthesis Arabidopsis thaliana Prunasin and amygdalin are cyanogenic glucosides, chemical compounds that can release toxic hydrogen cyanide after animal ingestion as a chemical defence. These compounds are also responsible for the bitter taste in many seeds, such as almonds, peaches or apples. Prunasin is transformed into amygdalin during fruit ripening. Cyanogenic glycosides are typically derived from amino acids, such as phenylalanine. This pathway involves the conversion of phenylalanine into prunasin and amygdalin by the enzyme L-phenylalanine N-monooxygenase (CYP79A2) and some other enzymes in the Arabidopsis thaliana species BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ashley Zubkowski Created On: May 13, 2021 at 11:30 Last Updated: May 13, 2021 at 11:30