PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146150 View Pathway	drug action Protirelin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:31 Last Updated: October 07, 2023 at 17:31
PW064773 View Pathway	signaling Protocadherin Fat 1 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: June 20, 2018 at 03:13 Last Updated: June 20, 2018 at 03:13
PW145815 View Pathway	drug action Protokylol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:44 Last Updated: October 07, 2023 at 16:44
PW144470 View Pathway	drug action Protriptyline Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:42 Last Updated: October 07, 2023 at 13:42
PW176124 View Pathway	metabolic Protriptyline Predicted Metabolism Pathway new Homo sapiens Metabolites of Protriptyline are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:08 Last Updated: November 29, 2023 at 14:08
PW132492 View Pathway	metabolic Proxibarbal Drug Metabolism Homo sapiens Proxibarbal is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Proxibarbal passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:04 Last Updated: September 21, 2023 at 22:04
PW146622 View Pathway	drug action Proxibarbal Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:39 Last Updated: October 07, 2023 at 18:39
PW000909 View Pathway	metabolic PRPP Biosynthesis Escherichia coli The biosynthesis of phosphoribosyl pyrophosphate begins as a product of the pentose phosphate and D-ribose 5-phosphate interaction. When catalyzed with a phosphopentomutase, the product is a ribose 1-phosphate. Ribose 1-phosphate can interact spontaneously with ATP resulting in a release of hydrogen ion, ADP and a ribose 1,5-biphosphate. Ribose 1,5-biphosphate is then phosphorylated through a ribose 1,5-bisphosphokinase resulting in the release of ADP and phosphoribosyl pyrophosphate. Phosphoribosyl pyrophosphate will then participate in the purine nucleotides de novo biosynthesis pathway. Alternatively pentose phosphate and D-ribose 5-phosphate's interaction can be phosphorylated through an ATP driven ribose-phosphate diphosphokinase resulting in a release of a hydrogen ion, an AMP and a phosphoribosyl pyrophosphate which will again participate in the purine nucleotides de novo biosynthesis pathway. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: May 29, 2015 at 13:29 Last Updated: May 29, 2015 at 13:29
PW122417 View Pathway	metabolic PRPP Biosynthesis Saccharomyces cerevisiae The biosynthesis of phosphoribosyl pyrophosphate begins with a product of the pentose phosphate, D-ribose 5-phosphate interact with a phosphopentomutase resulting in a Ribose 1-phosphate or it can be phosphorylated through an ATP driven ribose-phosphate diphosphokinase resulting in a release of a hydrogen ion, an AMP and a phosphoribosyl pyrophosphate. The latter compound is then involved in the purine nucleotides de novo biosynthesis pathway. Ribose 1-phosphate can interact spontaneously with ATP resulting in a release of hydrogen ion, ADP and a ribose 1,5-biphosphate. The latter compound is then phosphorylated through a ribose 1,5-bisphosphokinase resulting in the release of ADP and phosphoribosyl pyrophosphate. The latter compound is then involved in the purine nucleotides de novo biosynthesis pathway. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Debra Lipton Created On: March 27, 2019 at 15:16 Last Updated: March 27, 2019 at 15:16
PW128663 View Pathway	drug action Prucalopride Action Pathway Homo sapiens Prucalopride acts as a selective stimulator of the 5-HT4 receptors while having no interaction with hERG channel or 5-HT1 receptors which reduces significantly the cardiovascular risk found in other similar drugs. 5-HT4 receptors can be found throughout the gastrointestinal tract primarily in smooth muscle cells, enterochromaffin cells, and myenteric plexus. Its activation produces the release of acetylcholine which is the major excitatory neurotransmitter in the GI tract. Hence, prucalopride stimulates motility by interacting specifically with 5-HT4 receptors in the GI tract which causes a release of acetylcholine and further contraction of the muscle layer of the colon and relaxation of the circular muscle layer leading to the propulsion of luminal content. Prucalopride is indicated for the treatment of chronic idiopathic constipation (CIC) in adults. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: September 08, 2023 at 15:12 Last Updated: September 08, 2023 at 15:12