PathWhiz

PathWhiz ID	Pathway	Meta Data
PW002054 View Pathway	metabolic Putrescine Degradation II Escherichia coli This pathway demonstrates the degradation of extracellular putrescine in E.coli. Putrescine is imported by putrescine transporter (encoded by puuP gene). Putrescine is Î³-glutamylated by activation of ATP which generates Î³-glutamyl-putrescine, phosphate, and ADP. Î³-glutamyl-putrescine is oxidized by gamma-glutamylputrescine oxidoreductase to form Î³-glutamyl-Î³-butyraldehyde, also produce ammonium and water. Gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase dehydrogenates Î³-glutamyl-Î³-butyraldehyde to Î³-glutamyl-Î³-aminobutyrate, which is then dehydrogenated into Î³-Aminobutyric acid and L-Glutamic acid by Î³-glutamyl-Î³-aminobutyrate hydrolase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: October 08, 2015 at 13:18 Last Updated: October 08, 2015 at 13:18
PW122273 View Pathway	metabolic py Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 27, 2018 at 20:33 Last Updated: October 27, 2018 at 20:33
PW248225 View Pathway	metabolic Pyocyanine biosynthesis Pseudomonas aeruginosa Pyocyanin biosynthesis involves a sequence of enzymatic activities that occur within the bacterial cell. The precursor molecule for pyocyanin production, chorismate, is produced from major metabolic pathways within the bacterial cell, such as phenylalanine, tyrosine, and tryptophan biosynthesis. These precursors are enzymatically transformed to pyocyanin by a sequence of processes facilitated by particular enzymes, including phenazine biosynthesis proteins (PhzE,D, and F). These enzymes promote the condensation, cyclization, and oxidation events essential for the synthesis of pyocyanin, which plays an important role in the virulence and pathogenicity. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: May 17, 2024 at 13:23 Last Updated: May 17, 2024 at 13:23
PW294291 View Pathway	metabolic Pyocyanine biosynthesis to be deleted Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) Pyocyanin biosynthesis involves a sequence of enzymatic activities that occur within the bacterial cell. The precursor molecule for pyocyanin production, chorismate, is produced from major metabolic pathways within the bacterial cell, such as phenylalanine, tyrosine, and tryptophan biosynthesis. These precursors are enzymatically transformed to pyocyanin by a sequence of processes facilitated by particular enzymes, including phenazine biosynthesis proteins (PhzE,D, and F). These enzymes promote the condensation, cyclization, and oxidation events essential for the synthesis of pyocyanin, which plays an important role in the virulence and pathogenicity. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: September 09, 2024 at 11:56 Last Updated: September 09, 2024 at 11:56
PW132357 View Pathway	metabolic Pyrantel Drug Metabolism Homo sapiens Pyrantel is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Pyrantel passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:09 Last Updated: September 21, 2023 at 21:09
PW146272 View Pathway	drug action Pyrantel Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:50 Last Updated: October 07, 2023 at 17:50
PW144465 View Pathway	drug action Pyrazinamide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:41 Last Updated: October 07, 2023 at 13:41
PW128225 View Pathway	drug action Pyridostigmine Action Pathway Homo sapiens Pyridostigmine is a cholinesterase inhibitor used for the treatment of myasthenia gravis. It is usually administered intravenously and is very similar to neostigmine but with a less adverse effect profile and longer duration of action. The autoimmune disease known as myasthenia gravis is characterized defect of acetylcholine interacting at the neuromuscular junction. This results in muscle weakness, muscle loss and overall fatigue. Pyridostigmine inhibits the breakdown of acetylcholine allowing for an increase in activation and relieving the aforementioned symptoms. It specifically targets and inhibits acetylcholinesterase and cholinesterase, this increases extracellular levels of acetylcholine. Pyridostigmine is administered orally or intravenously, the latter having a better bioavailability. It is hydrolyzed in the blood by cholinesterases and in the liver by microsomal enzymes in the liver. Its main metabolite is 3-hydroxy-N-methyl-pyridinium and eliminated through the urine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 03, 2023 at 22:07 Last Updated: August 03, 2023 at 22:07
PW144663 View Pathway	drug action Pyridostigmine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:09 Last Updated: October 07, 2023 at 14:09
PW144262 View Pathway	drug action Pyridoxal phosphate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:03 Last Updated: October 07, 2023 at 13:03