PathWhiz

PathWhiz ID	Pathway	Meta Data
PW145394 View Pathway	drug action Penbutolol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:44 Last Updated: October 07, 2023 at 15:44
PW127455 View Pathway	drug action Penciclovir Action Pathway Homo sapiens Penciclovir is a topical nucleoside polymerase inhibitor used in the treatment of various herpes simplex virus (HSV) infections. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). In cells infected with HSV-1 or HSV-2, viral thymidine kinase phosphorylates penciclovir to a monophosphate form. The monophosphate form of the drug is then converted to penciclovir triphosphate by cellular kinases. Penciclovir triphosphate inhibits the activity of DNA polymerase by competing with its substrate dGTP. Less Viral DNA is transported into the nucleus, therefore, less viral DNA is integrated into the host DNA. Less viral proteins produced, fewer viruses can form. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: February 23, 2023 at 13:25 Last Updated: February 23, 2023 at 13:25
PW144427 View Pathway	drug action Penciclovir Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:37 Last Updated: October 07, 2023 at 13:37
PW144963 View Pathway	drug action Penicillamine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:48 Last Updated: October 07, 2023 at 14:48
PW123921 View Pathway	metabolic Penicillin and Cephalosporin Biosynthesis Streptomyces cattleya Penicillin, cephalosporins, and cephamycins are two out of five of the naturally occurring β-lactam antibiotics that contain the β-lactam ring. Penicillin is used to treat bacterial infections and is prevalently used by doctors to treat infections like streptococcal upper respiratory tract infections, scarlet fever, and erysipelas infections. Cephamycins and (very similar) cephalosporins on the other hand used for the treatment of severe bacterial infections like urinary tract infection, blood infection, bone and joint infection, and lower respiratory tract infection. They are all produced in different steps in the same biosynthesis pathway. This pathway shows the biosynthesis of penicillin, cephalosporin, and cephamycin in the bacteria Streptomyces cattleya. The pathway shows the production of penicillin by branching out at isopenicillin N to form penicillin using the enzyme beta-lactamase class A-like protein-containing pyridoxal 5'-phosphate as a cofactor and eventually penicillioic acid and 6-aminopenicillanic acid. The pathway then branches out at the intermediate deacetylcephalosporin C to eventually synthesize cephamycin C through a couple of cephalosporin intermediates and the enzyme CmcI hydroxylase. It also branches off and leads to the synthesis of cephalosporin C through the enzyme deacetylcephalosporin-C acetyltransferase. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Aadhavya Sivakumaran Created On: June 08, 2020 at 14:42 Last Updated: June 08, 2020 at 14:42
PW147014 View Pathway	metabolic Penicillin G Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:39 Last Updated: October 10, 2023 at 13:39
PW146989 View Pathway	metabolic Penicillin V Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:35 Last Updated: October 10, 2023 at 13:35
PW145666 View Pathway	drug action Pentaerythritol tetranitrate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:20 Last Updated: October 07, 2023 at 16:20
PW146585 View Pathway	drug action Pentafluoropropane Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:34 Last Updated: October 07, 2023 at 18:34
PW144314 View Pathway	drug action Pentagastrin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:22 Last Updated: October 07, 2023 at 13:22