PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176089 View Pathway	metabolic Mefenamic acid Predicted Metabolism Pathway new Homo sapiens Metabolites of Mefenamic acid are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 13:52 Last Updated: November 29, 2023 at 13:52
PW144484 View Pathway	drug action Mefloquine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:43 Last Updated: October 07, 2023 at 13:43
PW128127 View Pathway	drug action Megestrol acetate Action Pathway Homo sapiens Megestrol acetate is a synthetic progestational hormone initially developed as a contraceptive. Nowadays, it is used as a drug to treat anorexia and cachexia (or unexplained weight loss) and as an antineoplastic agent to treat inoperable breast cancer, endometrial cancer, and prostate cancer (palliative treatment). Megestrol has the same physiologic effects as natural progesterone: induction of secretory changes in the endometrium, increase in basal body temperature, and pituitary inhibition. By inhibiting the release of GnRH in the hypothalamus, there is a decrease in LH and FSH synthesis in the anterior pituitary gland. This results in a low level of LH, because the ovaries need a surge of this hormone to release the egg, there is no ovulation. The mechanism of action of megestrol's antianorexic and anticachetic is undetermined. It is thought to act by stimulating the appetite or by its metabolic effects (via interferences with the production or action of mediators like cachectin; inhibition of the adipocyte lipogenic enzymes). This drug is administered as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: July 20, 2023 at 14:15 Last Updated: July 20, 2023 at 14:15
PW144477 View Pathway	drug action Megestrol acetate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:42 Last Updated: October 07, 2023 at 13:42
PW146146 View Pathway	drug action Meglumine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:31 Last Updated: October 07, 2023 at 17:31
PW122536 View Pathway	protein mehri javadi Arabidopsis thaliana BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: July 02, 2019 at 01:50 Last Updated: July 02, 2019 at 01:50
PW124209 View Pathway	signaling MEKK2 IL6 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 12, 2020 at 08:39 Last Updated: October 12, 2020 at 08:39
PW122515 View Pathway	metabolic Melanin Biosynthesis Danio rerio Melanin is used in the skin of zebrafish for camouflage, mimicry, communication and protection from the sun. It is also a pigment in the eyes. Melanin is produced by melanocytes, organelles within the skin cells. Eumelanins are brown and black pigments, while other melanins exist, pheomelanin being yellow and red pigments, and neuromelanin being used in the brain. All of these pigments require tyrosine to start their synthesis. To start this pathway, tyrosine is transported into the melanosome by an amino acid transporter, and at this point it is metabolized to L-dopachrome . Within the melanosome membrane, L-dopachrome tautomerase converts L-dopachrome to 5,6-dihydroxyindole-2-carboxylic acid. This then interacts with tyrosinase-related protein 1a, which adds an oxygen molecule to form 5,6-indolequinone-2-carboxylic acid. This then undergoes a final reaction to form eumelanin. Alternatively, L-dopachrome can spontaneously lose a carbon dioxide molecule, forming 5,6-dihydroxyindole. Following this, it can interact with tyrosinase to form indole-5,6-quinone. Finally, another reaction occurs, forming eumelanin from this compound. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Eponine Oler Created On: May 24, 2019 at 15:09 Last Updated: May 24, 2019 at 15:09
PW002512 View Pathway	signaling Melanocortin 1 receptor Mus musculus BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: April 03, 2016 at 10:08 Last Updated: April 03, 2016 at 10:08
PW124207 View Pathway	metabolic Melatonin Biosynthesis Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 12, 2020 at 07:57 Last Updated: October 12, 2020 at 07:57