PathWhiz

PathWhiz ID	Pathway	Meta Data
PW127858 View Pathway	drug action Levoleucovorin Action Pathway Homo sapiens Levoleucovorin is a folate analog, used to counter the adverse effects of folic acid antagonists. Commonly used in combination with chemotherapy and 5-fluorouracil to treat patients with colorectal cancer. Folic acid is necessary in order to produce purines, pyrimidines and methionine required for DNA synthesis and replication. Once transported into the mitochondria, levoleucovorin acts to inhibit serine hydroxymethyltransferase. Without this enzyme, this halts the DNA synthesis and replication process as 5,10-Methylene-THF cannot be made. 5,10 Methylene THF is an intermediate in many amino acid pathways, such as methionine synthesis. It is also used in thymidine synthesis which is a nucleoside needed for DNA replication. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: June 11, 2023 at 20:35 Last Updated: June 11, 2023 at 20:35
PW146396 View Pathway	drug action Levoleucovorin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:06 Last Updated: October 07, 2023 at 18:06
PW146323 View Pathway	drug action Levomefolic acid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:56 Last Updated: October 07, 2023 at 17:56
PW132493 View Pathway	metabolic Levomenol Drug Metabolism Homo sapiens Levomenol is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Levomenol passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:05 Last Updated: September 21, 2023 at 22:05
PW146592 View Pathway	drug action Levomenol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:35 Last Updated: October 07, 2023 at 18:35
PW000654 View Pathway	drug action Levomethadyl Acetate Action Action Pathway Homo sapiens Levomethadyl acetate (also known as LAAM) is a synthetic synthetic opioid analgesic with multiple actions quantitatively similar to those as morphine, the most prominent of which involve the central nervous system and organs composed of smooth muscle. However, levomethadyl acetate is more active and more toxic than morphine. Levomethadyl acetate can bind to mu-type opioid receptor to activate associated G-protein in the sensory neurons of central nervous system (CNS), which will reduce the level of intracellular cAMP by inhibiting adenylate cyclase. The binding of levomethadyl acetate will eventually lead to reduced pain because of decreased nerve conduction and release of neurotransmitter. Therefore, methadyl acetate can reduce nerve conduction and decrease neurotransmitter release; so that perception of pain signals can be blocked. Levomethadyl acetate can also open calcium-dependent inwardly rectifying potassium channels (OP1 receptor agonist) to reduce neuronal excitability as well as lead to hyperpolarization. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: April 21, 2014 at 06:17 Last Updated: April 21, 2014 at 06:17
PW147017 View Pathway	metabolic Levomethadyl Acetate Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:39 Last Updated: October 10, 2023 at 13:39
PW000614 View Pathway	drug metabolism Levomethadyl Acetate Metabolism Pathway Homo sapiens Levomethadyl Acetate (also known as levacetylmethadol or levo-α-acetylmethadol) (LAAM), is a synthetic opioid structurally similar to methadone. It is an opioid agonist that has been used as an analgesic and to treat opioid dependence. Levomethadyl Acetate is metabolized by cytochrome P450 3A4 in two N-demethylation reactions to nor-levomethadyl acetate (nor-LAAM) and subsequently to dinor-levomethadyl acetate (dinor-LAAM). BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: September 11, 2013 at 22:33 Last Updated: September 11, 2013 at 22:33
PW132496 View Pathway	metabolic Levomilnacipran Drug Metabolism Homo sapiens Levomilnacipran is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Levomilnacipran passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:06 Last Updated: September 21, 2023 at 22:06
PW145891 View Pathway	drug action Levomilnacipran Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:54 Last Updated: October 07, 2023 at 16:54