PathWhiz

PathWhiz ID	Pathway	Meta Data
PW000325 View Pathway	drug action Chlorothiazide Action Pathway Homo sapiens Chlorothiazide (also known as Diuril) is an organic compound that used for diuretic. It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption. Solute carrier family 12 member 3 is also used for sodium reabsorption that count for 5% of total amount. Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium gradient that will increase the osmolarity in interstitium, which lead to establishment of osmotic gradient for water reabsorption. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:45 Last Updated: August 22, 2013 at 10:45
PW132394 View Pathway	metabolic Chlorothiazide Drug Metabolism Homo sapiens Chlorothiazide is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Chlorothiazide passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:26 Last Updated: September 21, 2023 at 21:26
PW144983 View Pathway	drug action Chlorothiazide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:51 Last Updated: October 07, 2023 at 14:51
PW145329 View Pathway	drug action Chloroxine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:34 Last Updated: October 07, 2023 at 15:34
PW146245 View Pathway	drug action Chloroxylenol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:46 Last Updated: October 07, 2023 at 17:46
PW057579 View Pathway	drug action Chlorphenamine H1-Antihistamine Action Homo sapiens Chlorphenamine (chlorpheniramine) is a first-generation alkylamine H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allergic conjunctivitis, and urticaria. Reducing the activity of the NF-κB immune response transcription factor through the phospholipase C and the phosphatidylinositol (PIP2) signalling pathways also decreases antigen presentation and the expression of pro-inflammatory cytokines, cell adhesion molecules, and chemotactic factors. Furthermore, lowering calcium ion concentration leads to increased mast cell stability which reduces further histamine release. First-generation antihistamines readily cross the blood-brain barrier and cause sedation and other adverse central nervous system (CNS) effects (e.g. nervousness and insomnia). Second-generation antihistamines are more selective for H1-receptors of the peripheral nervous system (PNS) and do not cross the blood-brain barrier. Consequently, these newer drugs elicit fewer adverse drug reactions. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: September 14, 2017 at 15:36 Last Updated: September 14, 2017 at 15:36
PW146872 View Pathway	drug action Chlorphenesin carbamate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:15 Last Updated: October 07, 2023 at 19:15
PW176427 View Pathway	metabolic Chlorphenesin carbamate Predicted Metabolism Pathway Homo sapiens Metabolites of Template3MB4 are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 08, 2023 at 15:11 Last Updated: December 08, 2023 at 15:11
PW144961 View Pathway	drug action Chlorphenesin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:48 Last Updated: October 07, 2023 at 14:48
PW176455 View Pathway	metabolic Chlorphenesin Predicted Metabolism Pathway Homo sapiens Metabolites of Chlorphenesin are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 12, 2023 at 14:42 Last Updated: December 12, 2023 at 14:42