PathWhiz

PathWhiz ID	Pathway	Meta Data
PW144593 View Pathway	drug action Montelukast Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:58 Last Updated: October 07, 2023 at 13:58
PW128566 View Pathway	drug action Moricizine Action Pathway Homo sapiens Moricizine is an antiarrhythmic used to treat arrhythmias (irregular heartbeats) and to maintain normal heart rate. it acts on heart muscles by inhibiting inward sodium channels. This results in a slowed atrioventricular nodal and His-Purkinje conduction, which decreases excitability conduction velocity, and automaticity. It decreases the maximum rate of phase 0 depolarization, but it does not affect action potential amplitude, sinoatrial (SA) nodal or intra-atrial conduction, or maximum diastolic potential. It minimally effects sinus cycle length and sinus node recovery time. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 04, 2023 at 12:54 Last Updated: September 04, 2023 at 12:54
PW132597 View Pathway	metabolic Moricizine Drug Metabolism Homo sapiens Moricizine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Moricizine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:34 Last Updated: September 21, 2023 at 22:34
PW144792 View Pathway	drug action Moricizine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:26 Last Updated: October 07, 2023 at 14:26
PW128454 View Pathway	drug action Moroctocog Alfa Action Pathway Homo sapiens Moroctocog alfa also known as Refacto AF and Xyntha, is a B-domain deleted recombinant factor VIII similar to the endogenous coagulation factor VIII. Moroctocog alfa is administered intravenously used to treat hemophilia A to control bleeding. It acts by replacing coagulation factor VIII which is deficient in those with hemophilia, this allows coagulation factor IX and X to be activated and facilitate the clotting cascade. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 29, 2023 at 12:37 Last Updated: August 29, 2023 at 12:37
PW000412 View Pathway	drug action Morphine Action Pathway Homo sapiens Morphine exerts its analgesic by acting on the mu-opioid receptor of sensory neurons. Binding to the mu-opioid receptor activates associated G(i) proteins. These subsequently act to inhibit adenylate cyclase, reducing the level of intracellular cAMP. G(i) also activates potassium channels and inactivates calcium channels causing the neuron to hyperpolarize. The end result is decreased nerve conduction and reduced neurotransmitter release, which blocks the perception of pain signals. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 22, 2013 at 10:46 Last Updated: August 22, 2013 at 10:46
PW122455 View Pathway	drug action Morphine Action Pathway Xuan Demo Homo sapiens Morphine is a class of drugs known as opioid (narcotic) analgesics. It can help to relieve moderate to severe pain, which by changing how your body feels and responds to pain. Morphine will activate mu-type opioid receptor, which the later will activate the G-proteins (guanine nucleotide-binding proteins). G proteins regulate metabolic enzymes, ion channels, transporter proteins. In this pathway, G proteins activate potassium voltage-gated channel (GIRK) as well as inhibit calcium voltage-gated channel and SNARE proteins. SNARE proteins mainly mediate the vesicle fusion. In this pathway, the synapse vesicles are required to be fused into cell membrane in order to release the neurotransmitter from brain cell. Inhibition of SNARE proteins deregulates the fusion of synapse vesicles which make neurotransmitter unable to be released as result. In order words, the pain signal (as in the neurotransmitters) won't be able to pass across the brain. Therefore, the pain is relieved in some extent. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: xuan cao Created On: April 15, 2019 at 16:37 Last Updated: April 15, 2019 at 16:37
PW144423 View Pathway	drug action Morphine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:36 Last Updated: October 07, 2023 at 13:36
PW000598 View Pathway	drug metabolism Morphine Metabolism Pathway Homo sapiens Morphine exerts its analgesic by acting on the mu-opioid receptor of sensory neurons. Binding to the mu-opioid receptor activates associated G(i) proteins. These subsequently act to inhibit adenylate cyclase, reducing the level of intracellular cAMP. G(i) also activates potassium channels and inactivates calcium channels causing the neuron to hyperpolarize. The end result is decreased nerve conduction and reduced neurotransmitter release, which blocks the perception of pain signals. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: September 11, 2013 at 22:33 Last Updated: September 11, 2013 at 22:33
PW126549 View Pathway	drug action Morphine Opioid Agonist Action Pathway Homo sapiens Morphine is an opioid agonist used for the relief of moderate to severe acute and chronic pain. Morphine can be administered orally as a capsule or tablet, intravenously, intrathecally, or as an epidural. Morphine-6-glucuronide, a metabolite of morphine, is responsible for approximately 85% of the response observed by morphine administration, however morphine may have greater analgesic efficacy. Morphine binds to mu opioid receptors, stimulating the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as GABA is inhibited. Opioids close N-type voltage-operated calcium channels and open calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization and reduced neuronal excitability. Morphine acts at A delta and C pain fibres in the dorsal horn of the spinal cord. By decreasing neurotransmitter action there is less pain transmittance into the spinal cord. This leads to less pain perception. Morphine also binds to delta and kappa opioid receptors in the nucleus accumbens where the reward pathway is activated. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: January 10, 2022 at 00:52 Last Updated: January 10, 2022 at 00:52