PathWhiz

PathWhiz ID	Pathway	Meta Data
PW122450 View Pathway	physiological Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: April 15, 2019 at 08:17 Last Updated: April 15, 2019 at 08:17
PW124347 View Pathway	disease Pathway in cancer Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: November 19, 2020 at 11:38 Last Updated: November 19, 2020 at 11:38
PW000974 View Pathway	metabolic PathWhiz Pt.2 - Video Learning Tutorials (Skeleton) Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: July 15, 2015 at 10:00 Last Updated: July 15, 2015 at 10:00
PW000954 View Pathway	metabolic PathWhiz Pt.2 Learning Tutorials (Membrane) Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Bioinformatics Learning Tutorials Created On: June 23, 2015 at 15:59 Last Updated: June 23, 2015 at 15:59
PW000969 View Pathway	metabolic PathWhiz Pt.2 Learning Tutorials (Red Membranes) Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Bioinformatics Learning Tutorials Created On: July 03, 2015 at 13:43 Last Updated: July 03, 2015 at 13:43
PW000945 View Pathway	metabolic PathWhiz Pt.2 Learning Tutorials (Skeleton) Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Bioinformatics Learning Tutorials Created On: June 12, 2015 at 16:50 Last Updated: June 12, 2015 at 16:50
PW146056 View Pathway	drug action Patiromer Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:18 Last Updated: October 07, 2023 at 17:18
PW126813 View Pathway	drug action Paxlovid (Drug Action) Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Nitya Khetarpal Created On: April 01, 2022 at 15:33 Last Updated: April 01, 2022 at 15:33
PW128514 View Pathway	drug action Pazopanib Action Pathway Homo sapiens Pazopanib is an antineoplastic agent utilized for treating advanced renal cell cancer and advanced soft tissue sarcoma in patients who have undergone prior chemotherapy. This small molecule functions as an inhibitor of multiple protein tyrosine kinases, demonstrating potential antineoplastic activity. By targeting vascular endothelial growth factor receptors (VEGFR-1, -2, -3), platelet-derived growth factor receptors (PDGFR-alpha, PDGFR-beta), and c-kit, which are integral to the angiogenesis pathway, pazopanib hinders tumor blood vessel formation, ultimately impeding tumor survival and growth. Notably, it achieves steady-state concentrations conducive to maximal inhibition of VEGFR2 phosphorylation and exhibits anti-tumor effects, leading to a reduction in tumor blood flow, increased tumor apoptosis, inhibited growth, and hypoxia in cancer cells. Although absorption is slow and incomplete, with nonlinear tendencies over a dose range of 50-2000 mg, pazopanib's potency in targeting key receptors underscores its significance as a therapeutic option for patients with advanced renal cell cancer and advanced soft tissue sarcoma. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Dorsa Yahya Rayat Created On: September 01, 2023 at 11:50 Last Updated: September 01, 2023 at 11:50
PW145718 View Pathway	drug action Pazopanib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:27 Last Updated: October 07, 2023 at 16:27