PathWhiz

PathWhiz ID	Pathway	Meta Data
PW147027 View Pathway	metabolic p-Aminobenzoic acid Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:40 Last Updated: October 10, 2023 at 13:40
PW146512 View Pathway	drug action P-nitrobiphenyl Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:23 Last Updated: October 07, 2023 at 18:23
PW146763 View Pathway	drug action p-Phenylenediamine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:58 Last Updated: October 07, 2023 at 18:58
PW176174 View Pathway	metabolic p-Phenylenediamine Predicted Metabolism Pathway new Homo sapiens Metabolites of p-Phenylenediamine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 30, 2023 at 10:09 Last Updated: November 30, 2023 at 10:09
PW146786 View Pathway	drug action p-tert-Butylphenol-formaldehyde resin (low molecular weight) Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:02 Last Updated: October 07, 2023 at 19:02
PW122142 View Pathway	signaling p38 MAPK Signaling Pathway Homo sapiens P38 group of MAP kinases, one of the four main sub-groups, serve as a nexus for signal transduction and play a vital role in numerous biological processes. For example, mammalian p38s show the roles and activation has been shown to occur in response to extracellular stimuli such as UV light, heat, osmotic shock, inflammatory cytokines (TNF-α & IL-1), and growth factors (CSF-1). In upstream kinases, there are two main MAPKKs that are known to activate p38, which are respectively MKK3 and MKK6. It is proposed that upstream kinases can differentially regulate p38 isoforms as evidenced by the inability of MKK3 to effectively activate p38β while MKK6 is a potent activator despite 80% homology between these two MKKs. This also suggests that activation of p38 isoforms can be specifically controlled through different regulators and coactivated by various combinations of upstream regulators. in downregulation of the p38, dephosphorylation plays a major role. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: xuan cao Created On: September 12, 2018 at 14:11 Last Updated: September 12, 2018 at 14:11
PW123686 View Pathway	signaling p53 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: January 19, 2020 at 04:15 Last Updated: January 19, 2020 at 04:15
PW123654 View Pathway	signaling p53 mediated apoptotic pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: November 26, 2019 at 00:11 Last Updated: November 26, 2019 at 00:11
PW101495 View Pathway	signaling p53 Signaling Pathway Mus musculus p53, named for its apparent molecular mass of 53 kilodaltons via SDS-PAGE analysis, is a protein that functions as a tumour suppressor and plays an important role in cell cycle regulation and cancer prevention. Over 50% of all cancers are theorized to involve p53-inactivating mutations. DNA damage, activated oncogenes, and oxidative stress can all produce stress signals to activate the p53 protein which is a transcriptional activator of >2500 p53-regulated genes. Activation of p53-regulated genes will lead to cellular senescence, cell cycle arrest, or apoptosis. Activated p53-regulated genes will also communicate with nearby cells for the purpose of DNA repair or feedback loop set-up that can either strengthen or weaken the stress responses of the p53 protein. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 23, 2018 at 12:19 Last Updated: August 23, 2018 at 12:19
PW101510 View Pathway	signaling p53 Signaling Pathway Bos taurus p53, named for its apparent molecular mass of 53 kilodaltons via SDS-PAGE analysis, is a protein that functions as a tumour suppressor and plays an important role in cell cycle regulation and cancer prevention. Over 50% of all cancers are theorized to involve p53-inactivating mutations. DNA damage, activated oncogenes, and oxidative stress can all produce stress signals to activate the p53 protein which is a transcriptional activator of >2500 p53-regulated genes. Activation of p53-regulated genes will lead to cellular senescence, cell cycle arrest, or apoptosis. Activated p53-regulated genes will also communicate with nearby cells for the purpose of DNA repair or feedback loop set-up that can either strengthen or weaken the stress responses of the p53 protein. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 23, 2018 at 12:23 Last Updated: August 23, 2018 at 12:23