PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146429 View Pathway	drug action Pacritinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:10 Last Updated: October 07, 2023 at 18:10
PW132289 View Pathway	metabolic Padeliporfin Drug Metabolism Homo sapiens Padeliporfin is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Padeliporfin passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:39 Last Updated: September 21, 2023 at 20:39
PW146929 View Pathway	drug action Padeliporfin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:22 Last Updated: October 07, 2023 at 19:22
PW146378 View Pathway	drug action Padimate O Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:04 Last Updated: October 07, 2023 at 18:04
PW127898 View Pathway	drug action Pafolacianine Action Pathway Homo sapiens Pafolacianine is a folate analogue used for the treatment of ovarian cancer. It targets the folate receptor in cancer cells where they are overexpressed. Pafolacianine binds to the receptor and is absorbed via receptor-mediated endocytosis. It is an optical imaging drug that binds to the overexpressed folate receptors in cancer cells that allows the visualization of the tumors. The metabolism of pafolacianine is not known, with the knowledge cytochrome P450 enzymes do not metabolize the drug. It is administered intravenously and is eliminated through the urine and feces. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: June 16, 2023 at 13:24 Last Updated: June 16, 2023 at 13:24
PW146913 View Pathway	drug action Pafolacianine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:20 Last Updated: October 07, 2023 at 19:20
PW002603 View Pathway	metabolic PAHs Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: June 04, 2016 at 21:10 Last Updated: June 04, 2016 at 21:10
PW145954 View Pathway	drug action Palbociclib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:03 Last Updated: October 07, 2023 at 17:03
PW128194 View Pathway	drug action Paliperidone Dopamine Antagonist Action Pathway Homo sapiens Paliperidone is the primary active metabolite of risperidone. The two antipsychotics are also metabolized differently, as risperidone is metabolized in the liver mainly by the polymorphic cytochrome P450 2D6 (CYP2D6) to its active metabolite 9-hydroxyrisperidone (paliperidone). Paliperidone, by contrast, is predominantly excreted unchanged in the urine The mechanism of action of paliperidone is unknown but it is likely to act via a similar pathway to risperidone as second generation antipsychotics. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug. It is available as an extended-release tablet, a once-monthly intramuscular injection, an every-three-month intramuscular injection, and a twice-yearly gluteal injection. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 01, 2023 at 10:59 Last Updated: August 01, 2023 at 10:59
PW145350 View Pathway	drug action Paliperidone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:37 Last Updated: October 07, 2023 at 15:37