PathWhiz

PathWhiz ID	Pathway	Meta Data
PW176345 View Pathway	metabolic Nebivolol Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:21 Last Updated: December 07, 2023 at 15:21
PW127653 View Pathway	drug action Necitumumab Action Pathway Homo sapiens Necitumumab is an intravenously administered recombinant monoclonal IgG1 antibody used to treat metastatic squamous non-small cell lung cancer. It is approved for use in combination with cisplatin and gemcitabine. It blocks other ligands of the EGFR from binding and activating numerous signalling cascades to promote cell growth, proliferation, and differentiation. The main cascades that are affected are the MAPK signalling cascade, which affects the synthesis of DNA for proliferation and differentiation and the PI3K/AKT1 signalling cascade which also affects proliferation but also controls apoptosis. MAPK is activated through the epidermal growth factor receptor on the cell membrane and goes on to phosphorylate and regulate the activities of several transcription factors affecting cellular growth and proliferation. The PI3K/AKT1 signalling cascade is apart of the PI3K/AKT1/mTOR pathway which is an intracellular signalling pathway that also helps regulate the cell cycle. This signalling cascade can affect the regulation and activity of transcription factors as well. In cancer, the PI3K/AKT1/mTOR is overactive reducing apoptosis and allowing excessive cellular proliferation. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: May 17, 2023 at 15:11 Last Updated: May 17, 2023 at 15:11
PW132239 View Pathway	metabolic Nedaplatin Drug Metabolism Homo sapiens Nedaplatin is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Nedaplatin passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:21 Last Updated: September 21, 2023 at 20:21
PW146590 View Pathway	drug action Nedaplatin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:35 Last Updated: October 07, 2023 at 18:35
PW144828 View Pathway	drug action Nedocromil Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:30 Last Updated: October 07, 2023 at 14:30
PW145237 View Pathway	drug action Nefazodone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:22 Last Updated: October 07, 2023 at 15:22
PW132524 View Pathway	metabolic Nefopam Drug Metabolism Homo sapiens Nefopam is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Nefopam passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:15 Last Updated: September 21, 2023 at 22:15
PW146511 View Pathway	drug action Nefopam Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:23 Last Updated: October 07, 2023 at 18:23
PW128252 View Pathway	drug action Nelarabine Action Pathway Homo sapiens Nelarabine is an antineoplastic agent from the nucleoside analog drug class. This drug is indicated in the treatment of T-cell lymphoblastic leukemia, particularly T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL), in both adult and pediatric patients whose disease has not responded to or has relapsed following at least two chemotherapy regimens. At the structure level of this molecule, it is a prodrug of the cytotoxic deoxyguanosine analog 9-ß-D-arabinofuranosylguanine (ara-G). Before entering the cells, it is metabolized by adenosine deaminase (ADA) to ara-G. The molecule then enters the cell to be phosphorylated three times, resulting in the formation of ara-G triphosphate (ara-GTP). Ara-GTP is the molecule with the cytotoxic activity. Since T lymphoblasts have a higher expression of deoxycytidine kinase, ara-G accumulates in higher quantities in T cells over B cells, thus showing higher toxicity to T lymphoblasts. Since ara-GTP accumulates in leukemic blasts, it will incorporate the DNA to exert its S phase-specific cytotoxic effects. This activity leads to the apoptosis of the cell. As a nucleoside analog, ara-GTP competes with endogenous deoxyGTP (dGTP) for incorporation into DNA. The mechanism of action that leads to apoptosis is not well understood. It is thought that the inclusion of ara-GTP into the DNA strand can impair proper DNA repair processes, leading to inhibition of DNA elongation, apoptosis, and cellular destruction. It is anticipated that overdosage of this drug result in severe neurotoxicity, myelosuppression, and potential death. Nelarabine is administered as an intravenous injection. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 10, 2023 at 10:25 Last Updated: August 10, 2023 at 10:25
PW145356 View Pathway	drug action Nelarabine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:38 Last Updated: October 07, 2023 at 15:38