PathWhiz

PathWhiz ID	Pathway	Meta Data
PW144376 View Pathway	drug action Methysergide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:30 Last Updated: October 07, 2023 at 13:30
PW128456 View Pathway	drug action Methysergide Mechanism of Action Action Pathway Homo sapiens Methysergide is an ergot derivative that is a congener of lysergic acid diethylamide. It antagonizes the effects of serotonin in blood vessels and gastrointestinal smooth muscle. Methysergide is a semisynthetic ergot alkaloid ergometrine derivative, introduced in pharmacotherapy for migraine prophylaxis as a specific serotonin (5HT) receptor antagonist. Methysergide is not just a 5HT2 antagonist, it is also a 5HT1 agonist. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: August 29, 2023 at 12:43 Last Updated: August 29, 2023 at 12:43
PW000712 View Pathway	drug action Metiamide Action Pathway Homo sapiens Metiamide is a histamine H2-receptor antagonist that can bind and inhibit histamine H2-receptor to prevent the histamine effects on basolateral memrbane in gastric parietal cell. Binding and inhibition of histamine H2-receptor can lead to decreased gastric acid secretion so that lowering gastric volume as well as acidity. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: June 23, 2014 at 05:37 Last Updated: June 23, 2014 at 05:37
PW124516 View Pathway	drug action Metiamide H2 Anti-Histamine Action Pathway Homo sapiens Metiamide is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epithelium. Ranitidine binds reversibly to the histamine H2 receptor blocking histamine from binding instead. This blocks the downstream Gs cascade which produces cyclic adenosine monophosphate (cAMP) which is an activator for the potassium-hydrogen ATPase pump (H+/K+ ATPase pump). The pump is responsible for secreting hydrogen ions into the stomach lumen increasing the acidity of the stomach environment. By blocking adenylate cyclase signalling pathway from the histamine H2 receptor less hydrogen ions are secreted into the stomach lumen increasing the pH. The less acidic environment doesn't irritate the stomach as much. The H+/K+ ATPase pump can still be activated through gastrin and acetylcholine through the phospholipase C signalling pathway, but blocking the adenylate cyclase pathway helps reduce the acidity. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Kristen Yee Created On: February 09, 2021 at 11:59 Last Updated: February 09, 2021 at 11:59
PW176950 View Pathway	drug action Meticillin Action Pathway Escherichia coli Meticillin is a 1-β methyl-carbapenem that is structurally related to beta-lactam antibiotics.5 It was first authorized for use in the US in November 2001 and in Europe in April 2002. Shown to be effective against a wide range of Gram-positive and Gram-negative aerobic and anaerobic bacteria, ertapenem is used to treat various bacterial infections. Meticillin exhibits a bactericidal mode of action. It works by binding to and inhibiting bacterial penicillin-binding proteins (PBPs).5 In Escherichia coli, it has a strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preferential binding to PBPs 2 and 3.5 Upon binding to PBPs, ertapenem inhibits bacterial cell wall synthesis by interfering with the lengthening and strengthening of the peptidoglycan portion of the cell wall, thereby inhibiting cell wall synthesis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: January 02, 2024 at 09:19 Last Updated: January 02, 2024 at 09:19
PW145470 View Pathway	drug action Meticillin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:53 Last Updated: October 07, 2023 at 15:53
PW146638 View Pathway	drug action Meticrane Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:41 Last Updated: October 07, 2023 at 18:41
PW000644 View Pathway	drug action Metipranolol Action Pathway Homo sapiens Metipranolol (also known as Betanol or Disorat) is an beta blocker (non-selective) that can used as an antihypertensive, antiarrhythmic and antiglaucoma agent. Metipranolol binds to beta1-adrenergic and beta2-adrenergic receptors in heart and vascular smooth muscle. Metipranolol demonstrates low intrinsic sympathomimetic activity, and weak local anesthetic (membrane-stabilizing) and myocardial depressant activity. Metipranolol can also reduce the producion of aqueous humor. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: April 20, 2014 at 17:20 Last Updated: April 20, 2014 at 17:20
PW127794 View Pathway	drug action Metipranolol Action Pathway (New) Homo sapiens Metipranolol is a beta-adrenergic antagonist used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. A beta-adrenergic antagonist effective for both beta-1 and beta-2 receptors. It is used as an antiarrhythmic, antihypertensive, and antiglaucoma agent. Metipranolol is a beta1 and beta2 (non-selective) adrenergic receptor-blocking agent that does not have significant intrinsic sympathomimetic, direct myocardial depressant, or local anesthetic (membrane-stabilizing) activity. Metipranolol is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Metipranolol, when applied topically to the eye, has the action of reducing elevated, as well as normal, intraocular pressure, whether or not accompanied by glaucoma. Elevated intraocular pressure is a major risk factor in the pathogenesis of glaucomatous visual field loss and optic nerve damage. Metipranolol reduces intraocular pressure with little or no effect on pupil size or accommodation in contrast to the miosis which cholinergic agents are known to produce. It appears that the ophthalmic beta-adrenergic blocking agents reduce aqueous humor production, as demonstrated by tonography and fluorophotometry. A slight increase in aqueous humor outflow may be an additional mechanism. Some side effects of using metipranolol may include changes in vision, difficulty breathing, irregular heartbeat, and bloody nose. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: June 02, 2023 at 11:16 Last Updated: June 02, 2023 at 11:16
PW145300 View Pathway	drug action Metipranolol Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:30 Last Updated: October 07, 2023 at 15:30