PathWhiz

PathWhiz ID	Pathway	Meta Data
PW121850 View Pathway	disease D-Glyceric Acidura Mus musculus D-Glyceric aciduria is an extremely rare inherited inborn error of metabolism (IEM) of serine and fructose metabolism. It is an autosomal recessive disorder that is caused by a defect in the D-glycerate kinase (GLYCTK) gene. GLYCTK codes for D-glycerate kinase, an enzyme that is responsible for phosphorylating D-glyceric acid into phosphoglycerate. D-Glycerate kinase is an enzyme that participates in 3 metabolic pathways: (1) serine/glycine/threonine metabolism, (2) glycerolipid metabolism, and (3) glyoxylate-dicarboxylate metabolism (which is a minor pathway in fructose metabolism). Defects in the enzyme will lead to accumulations of D-glyceric acid in tissues and biofluids. D-Glyceric aciduria was first described in 1974 and is characterized by elevated levels of D-glyceric acid in the urine. Clinical symptoms of D-glyceric aciduria are highly variable. Some patients have neurological symptoms, with severe mental retardation, seizures, microcephaly, and sometimes early death, whereas others have a mild phenotype with only mild speech delay or even normal development. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:50 Last Updated: September 10, 2018 at 15:50
PW127272 View Pathway	disease D-Glyceric Aciduria Homo sapiens D-Glyceric aciduria is an extremely rare inherited inborn error of metabolism (IEM) of serine and fructose metabolism. It is an autosomal recessive disorder that is caused by a defect in the D-glycerate kinase (GLYCTK) gene. GLYCTK codes for D-glycerate kinase, an enzyme that is responsible for phosphorylating D-glyceric acid into phosphoglycerate. D-Glycerate kinase is an enzyme that participates in 3 metabolic pathways: (1) serine/glycine/threonine metabolism, (2) glycerolipid metabolism, and (3) glyoxylate-dicarboxylate metabolism (which is a minor pathway in fructose metabolism). Defects in the enzyme will lead to accumulations of D-glyceric acid in tissues and biofluids. D-Glyceric aciduria was first described in 1974 and is characterized by elevated levels of D-glyceric acid in the urine. Clinical symptoms of D-glyceric aciduria are highly variable. Some patients have neurological symptoms, with severe mental retardation, seizures, microcephaly, and sometimes early death, whereas others have a mild phenotype with only mild speech delay or even normal development. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: November 25, 2022 at 11:48 Last Updated: November 25, 2022 at 11:48
PW145518 View Pathway	drug action D-Methionine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:59 Last Updated: October 07, 2023 at 15:59
PW012890 View Pathway	metabolic D-myo-Inositol (1,4,5)-Trisphosphate Biosynthesis Arabidopsis thaliana D-myo-inositol (1,4,5)-trisphosphate biosynthesis is a pathway that occurs in the cytosol by which myo-inositol becomes D-myo-inositol (1,4,5)-trisphosphate (IP3), a secondary messenger molecule used in signal transduction and lipid signaling in biological cells . This pathway consists of a few cell membrane-associated enzymes (coloured dark green in the image): phosphatidylinositol 4-phosphate 5-kinase and phosphoinositide phospholipase C. First, phosphatidylinositol synthase uses a a CDP-diacylglycerol to catalyze a reaction whereby myo-inositol is converted into an an L-1-phosphatidyl-inositol. It requires magnesium or manganese ions as cofactors. Second, phosphatidylinositol 4-kinase uses ATP to catalyze the conversion of an L-1-phosphatidyl-inositol to a 1-phosphatidyl-1D-myo-inositol 4-phosphate. Third, phosphatidylinositol 4-phosphate 5-kinase uses ATP to catalyze the conversion of a 1-phosphatidyl-1D-myo-inositol 4-phosphate to a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate. Alternatively, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate is predicted to be synthesized by a still undiscovered phosphatidylinositol-5-phosphate 4-kinase from ATP and a 1-phosphatidyl-1D-myo-inositol 5-phosphate. Finally, phosphoinositide phospholipase C uses water to catalyze the conversion of a 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to D-myo-inositol (1,4,5)-trisphosphate, producing 1,2-diacyl-sn-glycerol and a proton as byproducts. Phosphoinositide phospholipase C requires calcium as a cofactor. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: February 22, 2017 at 12:10 Last Updated: February 22, 2017 at 12:10
PW126912 View Pathway	metabolic d-psicose metabolism Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: May 11, 2022 at 14:01 Last Updated: May 11, 2022 at 14:01
PW342424 View Pathway	metabolic D-Serine Degradation Fusobacterium periodonticum 1_1_41FAA The degradation of D-serine begins with the transport of D-serine into the cytosol through a cycA. Once in the cytosol D-serine reacts with ammonia-lyase resulting in the release of a hydrogen ion, water and a 2-aminoprop-2-enoate. This compound in turn reacts spontaneously to produces 2-iminipropanoate. This compound in turn reacts with water and hydrogen ion spontaneously resulting in the release of ammonium and apyruvate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: October 31, 2024 at 19:06 Last Updated: October 31, 2024 at 19:06
PW342400 View Pathway	metabolic D-Serine Degradation Capnocytophaga sputigena ATCC 33612 The degradation of D-serine begins with the transport of D-serine into the cytosol through a cycA. Once in the cytosol D-serine reacts with ammonia-lyase resulting in the release of a hydrogen ion, water and a 2-aminoprop-2-enoate. This compound in turn reacts spontaneously to produces 2-iminipropanoate. This compound in turn reacts with water and hydrogen ion spontaneously resulting in the release of ammonium and apyruvate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: October 31, 2024 at 18:52 Last Updated: October 31, 2024 at 18:52
PW342378 View Pathway	metabolic D-Serine Degradation Parabacteroides johnsonii DSM 18315 The degradation of D-serine begins with the transport of D-serine into the cytosol through a cycA. Once in the cytosol D-serine reacts with ammonia-lyase resulting in the release of a hydrogen ion, water and a 2-aminoprop-2-enoate. This compound in turn reacts spontaneously to produces 2-iminipropanoate. This compound in turn reacts with water and hydrogen ion spontaneously resulting in the release of ammonium and apyruvate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: October 31, 2024 at 18:39 Last Updated: October 31, 2024 at 18:39
PW358952 View Pathway	metabolic D-Serine Degradation Escherichia coli O157:H7 str. TW14359 The degradation of D-serine begins with the transport of D-serine into the cytosol through a cycA. Once in the cytosol D-serine reacts with ammonia-lyase resulting in the release of a hydrogen ion, water and a 2-aminoprop-2-enoate. This compound in turn reacts spontaneously to produces 2-iminipropanoate. This compound in turn reacts with water and hydrogen ion spontaneously resulting in the release of ammonium and apyruvate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: November 13, 2024 at 19:03 Last Updated: November 13, 2024 at 19:03
PW358957 View Pathway	metabolic D-Serine Degradation Escherichia coli O55:H7 str. CB9615 The degradation of D-serine begins with the transport of D-serine into the cytosol through a cycA. Once in the cytosol D-serine reacts with ammonia-lyase resulting in the release of a hydrogen ion, water and a 2-aminoprop-2-enoate. This compound in turn reacts spontaneously to produces 2-iminipropanoate. This compound in turn reacts with water and hydrogen ion spontaneously resulting in the release of ammonium and apyruvate. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: November 13, 2024 at 19:05 Last Updated: November 13, 2024 at 19:05