PathWhiz

PathWhiz ID	Pathway	Meta Data
PW123561 View Pathway	metabolic O-Antigen Building Blocks Biosynthesis Pseudomonas aeruginosa Lipopolysaccharide (LPS) is a major component of outer membrane which is consisted of lipid A-core (oligosaccharide) on both inner and outer region and O-antigen (known as distal repeating unit with four sugars: N-acetylglucosamine, glucose, rhamnose and galactose). O-antigen is part of three domains of LPS, which is attached to lipid A-core; however, O-antigen and lipid A-core are synthesized separately. In this pathway, synthesis of three of O-antigen sugars is demonstrated. UDP-α-D-galactose is converted to UDP-D-Galacto-1,4-furanose by facilitation of UDP-galactopyranose mutase. dTTP glucose-1-phosphate is derivatized to dTDP-rhamnose. Fructose-6-phosphate gains an amino group, incorporates an acetate moiety and then acquires a nucleoside diphosphate resulting in UDP-N-acetyl-D-glucosamine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 22:32 Last Updated: August 12, 2019 at 22:32
PW000213 View Pathway	disease Obesity / Metabolic Syndrome Homo sapiens In Obesity/Metabolic Syndrome, high plasma fatty acids regulate genes responsible for increase insulin resistance, visceral fat deposits, fatty acid oxidation, and thermogenesis. Many of these responses have a role in metabolic syndrome, obesity and diabetes. Glucocorticoid receptor (GR) regulates several genes that have been implicated in insulin sensitivity. The glucocorticoid receptor is activated by binding to cortisol which is supplied by the conversion of cortisone by corticosteroid 11-beta-dehydrogenase. The mechanism for increased visceral fat levels is the over expression of lipoprotein lipase from glucocorticoid receptor activity. Lipoprotein lipase increases free fatty acids in tissues by cleaving fatty acids from triacylglycerols. PPAR-gamma is a fatty acid activated transcription factor involved in a complicated regulatory network of transcription factors that modulated fatty acid oxidation, thermogenesis and mitochondria biogenesis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 20, 2013 at 13:15 Last Updated: August 20, 2013 at 13:15
PW145651 View Pathway	drug action Obeticholic acid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:18 Last Updated: October 07, 2023 at 16:18
PW146110 View Pathway	drug action Octasulfur Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:26 Last Updated: October 07, 2023 at 17:26
PW146173 View Pathway	drug action Octinoxate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:35 Last Updated: October 07, 2023 at 17:35
PW146209 View Pathway	drug action Octisalate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:40 Last Updated: October 07, 2023 at 17:40
PW146189 View Pathway	drug action Octocrylene Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:37 Last Updated: October 07, 2023 at 17:37
PW146958 View Pathway	drug action Odevixibat Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:26 Last Updated: October 07, 2023 at 19:26
PW128546 View Pathway	drug action Ofloxacin Action Pathway Haemophilus influenzae Ofloxacin is an antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract. Ofloxacin inhibits DNA gyrase (topoisomerase II) and topoisomerase IV. These proteins prevent supercoiling in bacterial DNA. The inhibition of DNA gyrase (topoisomerase II) and topoisomerase IV causes supercoiling of the bacterial DNA. This prevents DNA replication. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 01, 2023 at 22:11 Last Updated: September 01, 2023 at 22:11
PW145252 View Pathway	drug action Ofloxacin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:24 Last Updated: October 07, 2023 at 15:24