PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128458 View Pathway	drug action Dapsone Action Pathway Physalis cinerascens Dapsone is an antibacterial from the sulfone drug class. It is indicated for the treatment of acne vulgaris, Hansen's disease, and dermatitis herpetiformis. Its main action is against Mycobacterium leprae. This drug acts against bacteria and protozoa by binding to the dihydropteroate synthetase enzyme. This is a competitive inhibition in the active site of para-amino-benzoate on the protein. It results in the inhibition of an essential reaction in the synthesis of dihydrofolic acid. The inability to produce folic acid results in the inhibition of the growth of the bacteria or protozoa. This drug is mostly administered as a topical gel. It is also available as an oral tablet. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 29, 2023 at 14:55 Last Updated: August 29, 2023 at 14:55
PW144379 View Pathway	drug action Dapsone Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:31 Last Updated: October 07, 2023 at 13:31
PW144259 View Pathway	drug action Daptomycin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 13:02 Last Updated: October 07, 2023 at 13:02
PW132518 View Pathway	metabolic Daridorexant Drug Metabolism Homo sapiens Daridorexant is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Daridorexant passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:14 Last Updated: September 21, 2023 at 22:14
PW146904 View Pathway	drug action Daridorexant Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:19 Last Updated: October 07, 2023 at 19:19
PW127974 View Pathway	drug action Darifenacin Action Pathway Homo sapiens Darifenacin is an M3 muscarinic receptor blocker used to treat urinary incontinence. It can be found under the brand names Emselex and Enablex. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. Darifenacin is a competitive muscarinic receptor antagonist. In vitro studies using human recombinant muscarinic receptor subtypes show that darifenacin has greater affinity for the M3 receptor than for the other known muscarinic receptors (9 and 12-fold greater affinity for M3 compared to M1 and M5, respectively, and 59-fold greater affinity for M3 compared to both M2 and M4). Muscarinic receptors play an important role in several major cholinergically mediated functions, including contractions of the urinary bladder smooth muscle and stimulation of salivary secretion. Possible side effects of using derifenacin may include dry mouth, constipation, stomach pain, and weakness. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Hayley Created On: June 26, 2023 at 11:19 Last Updated: June 26, 2023 at 11:19
PW132591 View Pathway	metabolic Darifenacin Drug Metabolism Homo sapiens Darifenacin is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Darifenacin passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 22:32 Last Updated: September 21, 2023 at 22:32
PW144618 View Pathway	drug action Darifenacin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:03 Last Updated: October 07, 2023 at 14:03
PW146569 View Pathway	drug action Darolutamide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:32 Last Updated: October 07, 2023 at 18:32
PW176014 View Pathway	metabolic Darolutamide Predicted Metabolism Pathway new Homo sapiens Metabolites of Darolutamide are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 13:14 Last Updated: November 29, 2023 at 13:14