PathWhiz

PathWhiz ID	Pathway	Meta Data
PW144955 View Pathway	drug action Perphenazine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:47 Last Updated: October 07, 2023 at 14:47
PW128129 View Pathway	drug action Perphenazine Mechanism of Action Action Pathway Homo sapiens Perphenazine is a piperazinyl phenothiazine first generation antipsychotic that acts on the central nervous system, and has a greater behavioral potency than other phenothiazine derivatives whose side chains do not contain a piperazine moiety. Binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre. Perphenazine also binds the alpha adrenergic receptor. This receptor's action is mediated by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: July 20, 2023 at 15:20 Last Updated: July 20, 2023 at 15:20
PW123652 View Pathway	drug action peter peter BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: November 17, 2019 at 18:03 Last Updated: November 17, 2019 at 18:03
PW146205 View Pathway	drug action Petrolatum Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:40 Last Updated: October 07, 2023 at 17:40
PW146575 View Pathway	drug action Pexidartinib Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:33 Last Updated: October 07, 2023 at 18:33
PW176283 View Pathway	metabolic Pexidartinib Predicted Metabolism Pathway Homo sapiens Metabolites of Pexidartinib are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 04, 2023 at 14:38 Last Updated: December 04, 2023 at 14:38
PW123681 View Pathway	signaling PGE2 receptor signaling Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: January 10, 2020 at 14:33 Last Updated: January 10, 2020 at 14:33
PW012893 View Pathway	metabolic Phaseic Acid Biosynthesis Arabidopsis thaliana Phaseic acid biosynthesis is a pathway that begins in the chloroplast and ends in the cytosol by which violaxanthin becomes phaseic acid (PA) and its derivative dihydrophaseic acid (DPA), synthesizing abscisic acid in the process. PA and DPA are inactive forms of abscisic acid whose synthesis provides a mechanism for controlling abscisic acid concentration. First, neoxanthin synthase catalyzes the opening of the violaxanthin epoxide ring to form neoxanthin. Second, a yet unidentified neoxanthin isomerase is theorized to isomerize neoxanthin to 9'-cis-neoxanthin. Third, 9-cis-epoxycarotenoid dioxygenase (NCED) uses oxygen to cleave 9'-cis-neoxanthin to form xanthoxin and C25-allenic-apo-aldehyde. This enzyme requires Fe2+ as a cofactor. Next, a xanthoxin transporter is theorized to export xanthoxin from the chloroplast into the cytosol to continue abscisic acid biosynthesis, but it has yet to be discovered. Fourth, xanthoxin dehydrogenase, located in the cytosol, catalyzes the conversion of xanthoxin and NAD to abscisic aldehyde, NADH, and a proton with the help of a molybdenum cofactor (MoCo). Fifth, abscisic-aldehyde oxidase converts abscisic aldehyde, water, and oxygen into hydrogen peroxide, hydrogen ion, and abscisic acid. Sixth, abscisic acid 8'-hydroxylase / abscisic acid 9'-hydroxylase uses NADPH, oxygen, and a proton to convert abscisic acid into 8'-hydroxyabscisate and water. Seventh, 8'-hydroxyabscisate spontaneously becomes phaseic acid. Eighth, the predicted enzyme phaseic acid reductase (coloured orange in the image) is theorized to catalyze the conversion of phaseic acid into dihydroxyphaseic acid. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Carin Li Created On: February 22, 2017 at 21:15 Last Updated: February 22, 2017 at 21:15
PW145210 View Pathway	drug action Phenacemide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:19 Last Updated: October 07, 2023 at 15:19
PW176350 View Pathway	metabolic Phenacemide Predicted Metabolism Pathway Homo sapiens Metabolites of sildenafil are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: December 07, 2023 at 15:25 Last Updated: December 07, 2023 at 15:25