PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128327 View Pathway	drug action Phentermine Norepinephrine Reuptake transporter Satiety Action Pathway Homo sapiens Phentermine is an amine anorectic agent used in weight reduction in cases of exogenous obesity as an adjunct or alone. It is chemically related to amphetamine. It is thought that the primary way phentermine works is by inducing a reduction in appetite, potentially through the elevation of leptin levels. However, it's believed that there are likely additional mechanisms to help reduce the weight. This molecule also acts by releasing more noradrenaline from the presynaptic vesicles situated in the lateral hypothalamus. This elevation in this hormone's concentration within the synaptic cleft triggers the activation of beta2-adrenergic receptors. This drug also impacts dopamine levels, along with its consequential influence on serotonin. These combined effects lead to a continuous fight-or-flight response within the body, diminishing hunger signals. Phentermine inhibits the sodium-dependent noradrenaline transporter, the sodium-dependent serotonin transporter, and the sodium-dependent dopamine transporter. This drug is administered as an oral capsule. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 21, 2023 at 13:51 Last Updated: August 21, 2023 at 13:51
PW128346 View Pathway	drug action Phentermine Serotonin Reuptake transporter Satiety Action Pathway Homo sapiens Phentermine is an amine anorectic agent used in weight reduction in cases of exogenous obesity as an adjunct or alone. It is chemically related to amphetamine. It is thought that the primary way phentermine works is by inducing a reduction in appetite, potentially through the elevation of leptin levels. However, it's believed that there are likely additional mechanisms to help reduce the weight. This molecule also acts by releasing more noradrenaline from the presynaptic vesicles situated in the lateral hypothalamus. This elevation in this hormone's concentration within the synaptic cleft triggers the activation of beta2-adrenergic receptors. This drug also impacts dopamine levels, along with its consequential influence on serotonin. These combined effects lead to a continuous fight-or-flight response within the body, diminishing hunger signals. Phentermine inhibits the sodium-dependent noradrenaline transporter, the sodium-dependent serotonin transporter, and the sodium-dependent dopamine transporter. This drug is administered as an oral capsule. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Daphnee Created On: August 23, 2023 at 09:18 Last Updated: August 23, 2023 at 09:18
PW144804 View Pathway	drug action Phentolamine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:27 Last Updated: October 07, 2023 at 14:27
PW176116 View Pathway	metabolic Phentolamine Predicted Metabolism Pathway new Homo sapiens Metabolites of Phentolamine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 14:05 Last Updated: November 29, 2023 at 14:05
PW145809 View Pathway	drug action Phenyl aminosalicylate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:42 Last Updated: October 07, 2023 at 16:42
PW146213 View Pathway	drug action Phenyl salicylate Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:41 Last Updated: October 07, 2023 at 17:41
PW250842 View Pathway	metabolic Phenylacetate degradation Klebsiella electrica Phenylacetate degradation involves multiple enzymatic reactions that allow the bacterium to use phenylacetate as a carbon and energy source. Due to its hydrophobic nature, phenylacetate can enter bacterial cells via passive diffusion across the cell membrane. Once inside the cell, the enzyme phenylacetate-CoA ligase activates phenylacetate, converting it to phenylacetyl-CoA. This intermediate passes through several enzymatic processes, including oxidation, hydration, and cleavage, to produce metabolites like acetyl-CoA and succinyl-CoA, which then enter the citrate cycle for energy generation and biosynthesis. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: May 21, 2024 at 18:14 Last Updated: May 21, 2024 at 18:14
PW088227 View Pathway	metabolic Phenylacetate Metabolism Bos taurus Phenylacetate (or phenylacetic acid) metabolism involves two steps. The first step is the conversion of phenylacetate into phenylacetyl-CoA which is catalyzed by acyl-coenzyme A synthetase ACSM1 or acyl-coenzyme A synthetase ACSM2B. Coenzyme A and ATP are also involved in this first step and AMP and pyrophosphate will be generated during the first step of metabolism. In the second step, phenylacetyl-CoA and L-glutamine interacts with glycine N-acyltransferase to generate coenzyme A as well as phenylacetylglutamine, of which the latter will be excreted in the urine. Phenylacetate metabolism provides a route that facilitates the excretion of nitrogen for patients with urea cycle defects; hence, it is important for clinical purposes. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 11:27 Last Updated: August 10, 2018 at 11:27
PW088323 View Pathway	metabolic Phenylacetate Metabolism Rattus norvegicus Phenylacetate (or phenylacetic acid) metabolism involves two steps. The first step is the conversion of phenylacetate into phenylacetyl-CoA which is catalyzed by acyl-coenzyme A synthetase ACSM1 or acyl-coenzyme A synthetase ACSM2B. Coenzyme A and ATP are also involved in this first step and AMP and pyrophosphate will be generated during the first step of metabolism. In the second step, phenylacetyl-CoA and L-glutamine interacts with glycine N-acyltransferase to generate coenzyme A as well as phenylacetylglutamine, of which the latter will be excreted in the urine. Phenylacetate metabolism provides a route that facilitates the excretion of nitrogen for patients with urea cycle defects; hence, it is important for clinical purposes. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 10, 2018 at 13:45 Last Updated: August 10, 2018 at 13:45
PW000033 View Pathway	metabolic Phenylacetate Metabolism Homo sapiens Phenylacetate (or phenylacetic acid) metabolism involves two steps. The first step is the conversion of phenylacetate into phenylacetyl-CoA which is catalyzed by acyl-coenzyme A synthetase ACSM1 or acyl-coenzyme A synthetase ACSM2B. Coenzyme A and ATP are also involved in this first step and AMP and pyrophosphate will be generated during the first step of metabolism. In the second step, phenylacetyl-CoA and L-glutamine interacts with glycine N-acyltransferase to generate coenzyme A as well as phenylacetylglutamine, of which the latter will be excreted in the urine. Phenylacetate metabolism provides a route that facilitates the excretion of nitrogen for patients with urea cycle defects; hence, it is important for clinical purposes. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: August 01, 2013 at 13:54 Last Updated: August 01, 2013 at 13:54