| PathWhiz ID | Pathway | Meta Data |
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PW762139
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/14:1(11Z)/26:1(11Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 14:01 Last Updated: August 29, 2025 at 14:01 |
PW762145
View Pathway
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/14:1(9Z)/26:0)Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 14:11 Last Updated: August 29, 2025 at 14:11 |
PW762146
View Pathway
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/14:1(9Z)/26:1(11Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 14:13 Last Updated: August 29, 2025 at 14:13 |
PW762148
View Pathway
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/14:1(9Z)/28:0)Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 14:16 Last Updated: August 29, 2025 at 14:16 |
PW762149
View Pathway
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/14:1(9Z)/28:1(11Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 14:18 Last Updated: August 29, 2025 at 14:18 |
PW762150
View Pathway
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/14:1(9Z)/28:1(9Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 14:20 Last Updated: August 29, 2025 at 14:20 |
PW762151
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/14:1(9Z)/30:0)Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 14:21 Last Updated: August 29, 2025 at 14:21 |
PW762154
View Pathway
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/15:0/27:1(11Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 14:26 Last Updated: August 29, 2025 at 14:26 |
PW762155
View Pathway
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/15:0/27:1(9Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 14:28 Last Updated: August 29, 2025 at 14:28 |
PW762156
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/15:1(11Z)/25:0)Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 14:30 Last Updated: August 29, 2025 at 14:30 |