| PathWhiz ID | Pathway | Meta Data |
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PW762192
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/16:1(9Z)/28:0)Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 15:30 Last Updated: August 29, 2025 at 15:30 |
PW762193
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/16:1(9Z)/28:1(11Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 15:32 Last Updated: August 29, 2025 at 15:32 |
PW762194
View Pathway
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/16:1(9Z)/28:1(9Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 15:33 Last Updated: August 29, 2025 at 15:33 |
PW762195
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/16:1(9Z)/30:0)Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 15:35 Last Updated: August 29, 2025 at 15:35 |
PW762197
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/18:0/22:1(9Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 15:38 Last Updated: August 29, 2025 at 15:38 |
PW762198
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/18:0/24:1(11Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 15:40 Last Updated: August 29, 2025 at 15:40 |
PW762200
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/18:0/26:1(11Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 15:43 Last Updated: August 29, 2025 at 15:43 |
PW762201
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/18:0/26:1(9Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 15:45 Last Updated: August 29, 2025 at 15:45 |
PW762202
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/18:0/28:1(11Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 15:46 Last Updated: August 29, 2025 at 15:46 |
PW762203
View Pathway
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Cardiolipin Biosynthesis via MLCL(0:0/10:0/18:0/28:1(9Z))Escherichia coli
The biosynthesis of cardiolipin (CL) in bacteria begins in the cytoplasm. Dihydroxyacetone phosphate is reduced by glycerol-3-phosphate dehydrogenase to form glycerol 3-phosphate, using NADH as a cofactor. Glycerol 3-phosphate then reacts with an acyl-CoA via glycerol-3-phosphate acyltransferase, producing 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid, LysoPA). The resulting LysoPA undergoes acylation by 1-acylglycerol-3-phosphate O-acyltransferase, forming phosphatidic acid (PA). PA reacts with cytidine triphosphate (CTP) in a reaction catalyzed by phosphatidate cytidylyltransferase, yielding CDP-diacylglycerol (CDP-DG). CDP-DG is converted to phosphatidylglycerophosphate (PGP) by CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase, and PGP is then dephosphorylated by phosphatidylglycerophosphatase to produce phosphatidylglycerol (PG). CL is formed when PG reacts with another CDP-DG molecule under the action of cardiolipin synthase, producing CL and releasing cytidine monophosphate. Bacterial cardiolipin remodeling begins with the removal of an acyl chain from CL by a cardiolipin-specific phospholipase, producing 1-monolysocardiolipin (MLCL). The acyl chain is then reintroduced by a lysophosphatidylcholine acyltransferase (or similar bacterial acyltransferase), transferring an acyl group from a phospholipid donor (e.g., phosphatidylcholine) to MLCL, regenerating mature cardiolipin.
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Creator: Julia Wakoli Created On: August 29, 2025 at 15:48 Last Updated: August 29, 2025 at 15:48 |