PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146355 View Pathway	drug action Sinapultide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:00 Last Updated: October 07, 2023 at 18:00
PW146010 View Pathway	drug action Sincalide Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 17:11 Last Updated: October 07, 2023 at 17:11
PW145349 View Pathway	drug action Sinecatechins Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:37 Last Updated: October 07, 2023 at 15:37
PW146521 View Pathway	drug action Siponimod Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:24 Last Updated: October 07, 2023 at 18:24
PW144980 View Pathway	drug action Sirolimus Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:51 Last Updated: October 07, 2023 at 14:51
PW124520 View Pathway	protein Sirtuin pathway with Alzheimer's Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: February 09, 2021 at 17:50 Last Updated: February 09, 2021 at 17:50
PW126210 View Pathway	drug action Sitagliptin Action Pathway Homo sapiens Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used for the management of type 2 diabetes mellitus. Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients. Inhibition of DPP-4 by sitagliptin slows DPP-4 mediated inactivation of incretins like GLP-1. GLP-1 is then able to go on to stimulate insulin secretion in beta cells. GLP-1 activates GLP-1 receptors on beta cells, triggering the Gs signaling cascade by activating adenylate cyclase to produce cAMP. cAMP activates protein kinase A (PKA) and Rap guanine nucleotide exchange factor 4 (EPAC2). PKA inhibits the ATP-sensitive potassium channel, preventing K+ efflux, leading to an accumulation of K+ ions in the cell causing depolarization of the cell. This depolarization activates the voltage gated L-type calcium channel, causing calcium influx. PKA may also directly activate the voltage gated L-type calcium channel. EPAC2 activates the ryanodine receptor on the endoplasmic reticulum, causing calcium to move from the endoplasmic reticulum and into the cytosol. The high concentration of calcium ions in the cytosol triggers insulin release via exocytosis, lowering blood glucose levels. Sitagliptin may also increase insulin biosynthesis, increase beta cell proliferation, decrease beta cell apoptosis and decrease glucagon secretion since these are also effects mediated by GLP-1. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: August 26, 2021 at 19:15 Last Updated: August 26, 2021 at 19:15
PW145344 View Pathway	drug action Sitagliptin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 15:36 Last Updated: October 07, 2023 at 15:36
PW145697 View Pathway	drug action Sitaxentan Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:25 Last Updated: October 07, 2023 at 16:25
PW176176 View Pathway	metabolic Sitaxentan Predicted Metabolism Pathway new Homo sapiens Metabolites of Sitaxentan are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 30, 2023 at 10:10 Last Updated: November 30, 2023 at 10:10