PathWhiz

PathWhiz ID	Pathway	Meta Data
PW064735 View Pathway	metabolic TLR4-IL-1 IRAK pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: May 10, 2018 at 05:06 Last Updated: May 10, 2018 at 05:06
PW064786 View Pathway	physiological tnf Mus musculus BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: July 02, 2018 at 04:12 Last Updated: July 02, 2018 at 04:12
PW101526 View Pathway	signaling TNF/Stress Related Signaling Rattus norvegicus Tumour necrosis factor alpha (TNF-a) is a cytokine that activates TNF rector 1 (TNFR1) signalling complex. TNFR1 mediates cell death signalling and inflammation in response to cytokines, bacteria and cellular stress. The classical NFkB pathway involves activation of TNF receptor associated factor 2, receptor interacting serine/threonine protein kinase and death domains which activate the IKK complex, phosphorylating the IKB proteins triggering their degradation resulting in NF-kB dimers dissociation and release. Caspase 2 interacts with TNF-receptor associated factor 2 and receptor interacting serine/threonine protein kinase to activate NFkB. Mitogen activated protein kinases of the MAP3K family are also involved in TNFR1-mediated IKK activation. Mitogen activated kinases can phosphorylate IKK to activate it as well. Activation of Mitogen-activated protein kinase 8 and 14 are involved in the cross-talk of other inflammatory pathways. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 23, 2018 at 12:26 Last Updated: August 23, 2018 at 12:26
PW101496 View Pathway	signaling TNF/Stress Related Signaling Mus musculus Tumour necrosis factor alpha (TNF-a) is a cytokine that activates TNF rector 1 (TNFR1) signalling complex. TNFR1 mediates cell death signalling and inflammation in response to cytokines, bacteria and cellular stress. The classical NFkB pathway involves activation of TNF receptor associated factor 2, receptor interacting serine/threonine protein kinase and death domains which activate the IKK complex, phosphorylating the IKB proteins triggering their degradation resulting in NF-kB dimers dissociation and release. Caspase 2 interacts with TNF-receptor associated factor 2 and receptor interacting serine/threonine protein kinase to activate NFkB. Mitogen activated protein kinases of the MAP3K family are also involved in TNFR1-mediated IKK activation. Mitogen activated kinases can phosphorylate IKK to activate it as well. Activation of Mitogen-activated protein kinase 8 and 14 are involved in the cross-talk of other inflammatory pathways. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 23, 2018 at 12:19 Last Updated: August 23, 2018 at 12:19
PW101511 View Pathway	signaling TNF/Stress Related Signaling Bos taurus Tumour necrosis factor alpha (TNF-a) is a cytokine that activates TNF rector 1 (TNFR1) signalling complex. TNFR1 mediates cell death signalling and inflammation in response to cytokines, bacteria and cellular stress. The classical NFkB pathway involves activation of TNF receptor associated factor 2, receptor interacting serine/threonine protein kinase and death domains which activate the IKK complex, phosphorylating the IKB proteins triggering their degradation resulting in NF-kB dimers dissociation and release. Caspase 2 interacts with TNF-receptor associated factor 2 and receptor interacting serine/threonine protein kinase to activate NFkB. Mitogen activated protein kinases of the MAP3K family are also involved in TNFR1-mediated IKK activation. Mitogen activated kinases can phosphorylate IKK to activate it as well. Activation of Mitogen-activated protein kinase 8 and 14 are involved in the cross-talk of other inflammatory pathways. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 23, 2018 at 12:23 Last Updated: August 23, 2018 at 12:23
PW064784 View Pathway	protein TNF/Stress Related Signaling Homo sapiens Tumour necrosis factor alpha (TNF-a) is a cytokine that activates TNF rector 1 (TNFR1) signalling complex. TNFR1 mediates cell death signalling and inflammation in response to cytokines, bacteria and cellular stress. The classical NFkB pathway involves activation of TNF receptor associated factor 2, receptor interacting serine/threonine protein kinase and death domains which activate the IKK complex, phosphorylating the IKB proteins triggering their degradation resulting in NF-kB dimers dissociation and release. Caspase 2 interacts with TNF-receptor associated factor 2 and receptor interacting serine/threonine protein kinase to activate NFkB. Mitogen activated protein kinases of the MAP3K family are also involved in TNFR1-mediated IKK activation. Mitogen activated kinases can phosphorylate IKK to activate it as well. Activation of Mitogen-activated protein kinase 8 and 14 are involved in the cross-talk of other inflammatory pathways. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Debra Lipton Created On: June 26, 2018 at 14:07 Last Updated: June 26, 2018 at 14:07
PW123662 View Pathway	protein TNF/Stress Related Signaling 1575850680 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Faith Inello Created On: December 08, 2019 at 17:18 Last Updated: December 08, 2019 at 17:18
PW000688 View Pathway	drug action Tobramycin Action Pathway Homo sapiens Tobramycin (also named aktob or tobi) is an aminoglycoside antibiotic that can be used to treat various gram-negative bacterial infections such as the species of Pseudomonas. Bacterial 30S ribosomal subunit protein and four nucleotides of 16S rRNA will be bound with tobramycin irreversibly to cause misreading of mRNA; so that formation of mRNA could be prevented because of incorrect insertion of amino acids to polypeptide will result nonfunctional or toxic peptides. Therefore, there is no protein synthesis for bacteria. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: April 26, 2014 at 16:21 Last Updated: April 26, 2014 at 16:21
PW128347 View Pathway	drug action Tobramycin Action Pathway (new) Homo sapiens Tobramycin is an antibiotic that is commonly used to treat bacterial infections such as cystic fibrosis-associated bacterial, lower respiratory tract, urinary tract, eye, skin, and bone infections. This drug is a part of the aminoglycoside antibiotics family. It can be administered via inhalation, injection (intravenously or intramuscular), or even via topical cream. Tobramycin acts by binding to bacterial membranes causing displacement of divalent cations and increasing membrane permeability allowing entry into the bacterial cell. Once inside the bacterial cell, tobramycin then targets the bacterial 30S ribosome and binds to it, halting protein synthesis. It binds to the site where the normal base pairing of codon and anti-codon takes place as well as adding amino acids to the growing polypeptide chain, with this blocked it leads to termination of the chain and production of non-functional proteins. The adverse effects of tobramycin are not well known therefore if a patient is experiencing overdose hemodialysis should be performed to clear the excess of tobramycin as they are at risk of nephrotoxicity, ototoxicity, neuromuscular blockade, respiratory paralysis, and/or respiratory failure. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Selena Created On: August 23, 2023 at 10:22 Last Updated: August 23, 2023 at 10:22
PW144796 View Pathway	drug action Tobramycin Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:26 Last Updated: October 07, 2023 at 14:26