PathWhiz

PathWhiz ID	Pathway	Meta Data
PW146397 View Pathway	drug action Starch, corn Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 18:06 Last Updated: October 07, 2023 at 18:06
PW122175 View Pathway	protein Stat3 Signaling Pathway Mus musculus The STAT3 signalling pathway is a pathway activated by many different cytokines. It has also been found to be activated by many carcinogens. Cytokines are small proteins. These proteins are released by some of the cells in the immune system, and are vital to signalling pathways in the body of mammals. STAT3 is very important in the activation of the expression of certain mediators in the liver. STAT3 binds at the phosphotyrosine receptor which in turn phosphorylates tyrosine 705 at the C-terminal domain of STAT3, activating STAT3. If a receptor is missing tyrosine-kinase activity it will find tyrosine-kinases that are associated to the receptor, including JAK and Src when it is time for ligand engagement. Thanks to this recruitment, STAT3 is phosphorylated through the tyrosine phosphorylation cascade. This means that STAT3 is now activated, and its compounds disconnect from the receptor site, and relocate to the nucleus. Once there, the compounds bind to DNA response elements, and take part in many processes against target genes, such as apoptosis and cell proliferation, regulating their transcription. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 14:50 Last Updated: September 20, 2018 at 14:50
PW122199 View Pathway	protein Stat3 Signaling Pathway Bos taurus The STAT3 signalling pathway is a pathway activated by many different cytokines. It has also been found to be activated by many carcinogens. Cytokines are small proteins. These proteins are released by some of the cells in the immune system, and are vital to signalling pathways in the body of mammals. STAT3 is very important in the activation of the expression of certain mediators in the liver. STAT3 binds at the phosphotyrosine receptor which in turn phosphorylates tyrosine 705 at the C-terminal domain of STAT3, activating STAT3. If a receptor is missing tyrosine-kinase activity it will find tyrosine-kinases that are associated to the receptor, including JAK and Src when it is time for ligand engagement. Thanks to this recruitment, STAT3 is phosphorylated through the tyrosine phosphorylation cascade. This means that STAT3 is now activated, and its compounds disconnect from the receptor site, and relocate to the nucleus. Once there, the compounds bind to DNA response elements, and take part in many processes against target genes, such as apoptosis and cell proliferation, regulating their transcription. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 14:57 Last Updated: September 20, 2018 at 14:57
PW068597 View Pathway	protein Stat3 Signaling Pathway Homo sapiens The STAT3 signalling pathway is a pathway activated by many different cytokines. It has also been found to be activated by many carcinogens. Cytokines are small proteins. These proteins are released by some of the cells in the immune system, and are vital to signalling pathways in the body of mammals. STAT3 is very important in the activation of the expression of certain mediators in the liver. STAT3 binds at the phosphotyrosine receptor which in turn phosphorylates tyrosine 705 at the C-terminal domain of STAT3, activating STAT3. If a receptor is missing tyrosine-kinase activity it will find tyrosine-kinases that are associated to the receptor, including JAK and Src when it is time for ligand engagement. Thanks to this recruitment, STAT3 is phosphorylated through the tyrosine phosphorylation cascade. This means that STAT3 is now activated, and its compounds disconnect from the receptor site, and relocate to the nucleus. Once there, the compounds bind to DNA response elements, and take part in many processes against target genes, such as apoptosis and cell proliferation, regulating their transcription. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Jonas Patron Created On: July 31, 2018 at 15:06 Last Updated: July 31, 2018 at 15:06
PW122223 View Pathway	protein Stat3 Signaling Pathway Rattus norvegicus The STAT3 signalling pathway is a pathway activated by many different cytokines. It has also been found to be activated by many carcinogens. Cytokines are small proteins. These proteins are released by some of the cells in the immune system, and are vital to signalling pathways in the body of mammals. STAT3 is very important in the activation of the expression of certain mediators in the liver. STAT3 binds at the phosphotyrosine receptor which in turn phosphorylates tyrosine 705 at the C-terminal domain of STAT3, activating STAT3. If a receptor is missing tyrosine-kinase activity it will find tyrosine-kinases that are associated to the receptor, including JAK and Src when it is time for ligand engagement. Thanks to this recruitment, STAT3 is phosphorylated through the tyrosine phosphorylation cascade. This means that STAT3 is now activated, and its compounds disconnect from the receptor site, and relocate to the nucleus. Once there, the compounds bind to DNA response elements, and take part in many processes against target genes, such as apoptosis and cell proliferation, regulating their transcription. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 20, 2018 at 15:06 Last Updated: September 20, 2018 at 15:06
PW000722 View Pathway	drug action Stavudine Action Pathway Homo sapiens Acquired immunodeficiancy syndrome (AIDS) is generally accepted to be a consequence of infection with the retrovirus designated as human immunodeficiency virus (HIV-l). Stavudine is a potent and selective inhibitor of HIV-replication and of cytopathic effects in a variety of mammalian cells, and is relatively non-toxic to the uninfected human T-cell line H9. Stavudine, phosphorylates cellular enzymes to the mono-, di-, and triphosphates and is ultimately incorporated into the DNA of growing cells. A significant amount of radioactivity appears in the alkaline labile fraction of cells which are treated with Stavudine, due to terminal addition of Stavudine to DNA and the resultant chain termination. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: June 23, 2014 at 07:51 Last Updated: June 23, 2014 at 07:51
PW126446 View Pathway	drug action Stavudine Action Pathway (New) Homo sapiens Stavudine is a dideoxynucleoside used in the treatment of HIV infection. When HIV infects a cell, the virus first binds and fuses with the cell, releasing its nucleocapsid containing its RNA and reverse transcriptase into the cytosol of the cell. The reverse transcriptase converts the viral RNA into viral DNA in the cytosol. The viral DNA goes to the nucleus through the nuclear pore complex where it undergoes the process of transcription. The new viral RNA formed from transcription is transported back to the cytosol through the nuclear pore complex and translation occurs to produce viral proteins. These viral proteins are assembled and new HIV viruses bud from the cell. Stavudine enters the cell and is converted into stavudine monophosphate by thymidine kinase. Thymidylate kinase then converts stavudine monophosphate into stavudine diphosphate. Stavudine diphosphate is metabolized to stavudine triphosphate via nucleoside diphosphate kinase. Stavudine triphosphate is an analog of deoxyguanosine-5'-triphosphate (dGTP). Stavudine triphosphate inhibits the activity of HIV-1 reverse transcriptase by competing with its substrate, dGTP and by incorporation into viral DNA. Stavudine triphosphate lacks the 3'-OH group which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation, therefore, once stavudine triphosphate gets incorporated into DNA, this causes DNA chain termination, preventing the growth of viral DNA. Less viral proteins are therefore produced, and there is a reduction in new viruses being formed. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Karxena Harford Created On: December 05, 2021 at 22:07 Last Updated: December 05, 2021 at 22:07
PW132412 View Pathway	metabolic Stavudine Drug Metabolism Homo sapiens Stavudine is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Stavudine passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 21:34 Last Updated: September 21, 2023 at 21:34
PW144762 View Pathway	drug action Stavudine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 14:22 Last Updated: October 07, 2023 at 14:22
PW145528 View Pathway	drug action Stearic acid Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:00 Last Updated: October 07, 2023 at 16:00