PathWhiz

PathWhiz ID	Pathway	Meta Data
PW128663 View Pathway	drug action Prucalopride Action Pathway Homo sapiens Prucalopride acts as a selective stimulator of the 5-HT4 receptors while having no interaction with hERG channel or 5-HT1 receptors which reduces significantly the cardiovascular risk found in other similar drugs. 5-HT4 receptors can be found throughout the gastrointestinal tract primarily in smooth muscle cells, enterochromaffin cells, and myenteric plexus. Its activation produces the release of acetylcholine which is the major excitatory neurotransmitter in the GI tract. Hence, prucalopride stimulates motility by interacting specifically with 5-HT4 receptors in the GI tract which causes a release of acetylcholine and further contraction of the muscle layer of the colon and relaxation of the circular muscle layer leading to the propulsion of luminal content. Prucalopride is indicated for the treatment of chronic idiopathic constipation (CIC) in adults. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: September 08, 2023 at 15:12 Last Updated: September 08, 2023 at 15:12
PW145717 View Pathway	drug action Prucalopride Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:27 Last Updated: October 07, 2023 at 16:27
PW124237 View Pathway	metabolic Prueba Homo sapiens Prueba de la prueba de la prueba BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: October 17, 2020 at 19:57 Last Updated: October 17, 2020 at 19:57
PW124244 View Pathway	metabolic Prueba 2 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: October 18, 2020 at 21:10 Last Updated: October 18, 2020 at 21:10
PW124320 View Pathway	metabolic prueba 50000 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Valeria Created On: November 06, 2020 at 21:38 Last Updated: November 06, 2020 at 21:38
PW124161 View Pathway	disease prueba1111 Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Guest: Anonymous Created On: September 15, 2020 at 04:22 Last Updated: September 15, 2020 at 04:22
PW125983 View Pathway	metabolic Prunasin and Amygdalin Biosynthesis Arabidopsis thaliana Prunasin and amygdalin are cyanogenic glucosides, chemical compounds that can release toxic hydrogen cyanide after animal ingestion as a chemical defence. These compounds are also responsible for the bitter taste in many seeds, such as almonds, peaches or apples. Prunasin is transformed into amygdalin during fruit ripening. Cyanogenic glycosides are typically derived from amino acids, such as phenylalanine. This pathway involves the conversion of phenylalanine into prunasin and amygdalin by the enzyme L-phenylalanine N-monooxygenase (CYP79A2) and some other enzymes in the Arabidopsis thaliana species BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ashley Zubkowski Created On: May 13, 2021 at 11:30 Last Updated: May 13, 2021 at 11:30
PW132249 View Pathway	metabolic Prussian blue Drug Metabolism Homo sapiens Prussian blue is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis. Prussian blue passes through the liver and is then excreted from the body mainly through the kidney. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: September 21, 2023 at 20:24 Last Updated: September 21, 2023 at 20:24
PW145791 View Pathway	drug action Prussian blue Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 16:40 Last Updated: October 07, 2023 at 16:40
PW126799 View Pathway	drug action Pseudoephedrine Action Pathway Homo sapiens Pseudoephedrine is alpha and beta agonist used to treat nasal and sinus congestion as well as allergic rhinitis. It is in many cold and sinus medicines as well as allergy medicine. Pseudoephedrine's mechanism of action mainly occurs in the nose and sinuses. It primarily activates alpha adrenergic receptor 1A or 2A. Pseudoephedrine also inhibits sodium dependent noradrenaline receptors which prevents the reuptake of norepinephrine into the presynaptic neuron. This causes norepinephrine to accumulate in the synapse which also activates alpha adrenergic receptors. These receptors then activate the Gq protein cascade. This activates Phospolipase C which catalyzes Phosphatidylinositol 4,5-bisphosphate into Inositol 1,4,5-trisphosphate and Diacylglycerol. Diacylglycerol activates protain kinase C which activates the voltage-dependent calcium channel, allowing calcium to enter the cell. Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor on the sarcoplasmic reticulum which also allows calcium to enter the cell from the sarcoplasmic reticulum. This high concentration of calcium in the cytosol attaches to calmodulin which activates Myosin light chain kinase. This enzyme catalyzes Myosin light chain 3 into myosin LC-P which causes myosin to bind to actin and contract the muscle cell. The contraction of this smooth muscle causes the blood vessel to constrict. The contriction of blood vessels in the sinuses and nose lead to decongestion. Pseudophedrine also activates on beta receptors, and it inhibits sodium dependent dopamine and serotonin transporters, however not to the same effect or degree as it affects alpha receptors and the norepinephrine pathway. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: March 29, 2022 at 13:27 Last Updated: March 29, 2022 at 13:27