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Pathways

PathWhiz ID Pathway Meta Data

PW124069

Pw124069 View Pathway
signaling

chebulagic acid Metabolism 1559277983 1589861306 1597248631

Homo sapiens

PW124042

Pw124042 View Pathway
signaling

chebulagic acid Metabolism 1559277983 1596798296

Homo sapiens

PW123794

Pw123794 View Pathway
signaling

chebulagic acid Metabolism 1581167212

Homo sapiens

PW123807

Pw123807 View Pathway
signaling

chebulagic acid Metabolism 1581839290

Homo sapiens

PW123825

Pw123825 View Pathway
signaling

chebulagic acid Metabolism 1582757459

Homo sapiens

PW124219

Pw124219 View Pathway
physiological

chebulagic acid Metabolism 1602639807

Homo sapiens

PW124232

Pw124232 View Pathway
metabolic

chebulagic acid Metabolism 1602980507

Homo sapiens

PW124234

Pw124234 View Pathway
metabolic

chebulagic acid Metabolism 1602981862

Homo sapiens

PW128386

Pw128386 View Pathway
drug action

Dolasetron Serotonin antagonist Action Pathway

Homo sapiens
Dolasetron is a selective serotonin 5-HT3 receptor antagonist. In vivo, the drug is rapidly converted into its major active metabolite, hydrodolasetron, which seems to be largely responsible for the drug's pharmacological activity. The antiemetic activity of the drug is brought about through the inhibition of 5-HT3 receptors present both centrally (medullary chemoreceptor zone) and peripherally (GI tract). This inhibition of 5-HT3 receptors in turn inhibits the visceral afferent stimulation of the vomiting center, likely indirectly at the level of the area postrema, as well as through direct inhibition of serotonin activity within the area postrema and the chemoreceptor trigger zone.

PW128196

Pw128196 View Pathway
drug action

Donepezil Acetylcholinesterase Inhibitor Action Pathway

Homo sapiens
Donepezil is an acetylcholinesterase inhibitor that is used in the treatment of Alzheimer's Disease and dementia. It is administered orally or transdermally, sometimes in combination with memantine in order to treat moderate to severe dementia. Donepezil selectively inhibits the acetylcholinesterase enzyme, by doing so it is believed to enhance cholinergic transmission to relieve the symptoms of Alzheimer and dementia.